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A kind of water-soluble cross-linking agent and its preparation method and prepared electrospun collagen fiber

A cross-linking agent and water-soluble technology, which is applied in the field of electrospun collagen fiber preparation, can solve the problems of poor electrospinning property, difficult molecular chain entanglement, poor structural stability of electrospun collagen fiber, etc., and achieve good structural stability and mechanical properties , Increase the effect of chain entanglement

Active Publication Date: 2021-04-13
SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Aiming at the above-mentioned deficiencies in the prior art, the present invention provides a water-soluble cross-linking agent and its preparation method and the prepared electrospun collagen fiber, which can effectively solve the problem that the existing collagen has poor electrospinning property and is difficult to form sufficient molecular chains. Entanglement, the problem of poor structural stability of electrospun collagen fibers

Method used

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  • A kind of water-soluble cross-linking agent and its preparation method and prepared electrospun collagen fiber
  • A kind of water-soluble cross-linking agent and its preparation method and prepared electrospun collagen fiber
  • A kind of water-soluble cross-linking agent and its preparation method and prepared electrospun collagen fiber

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Effect test

Embodiment 1

[0039] A preparation method of electrospun collagen fibers, comprising the following steps:

[0040] (1) Dissolve 0.025 parts of aldehyde-containing norbornene-based hydrophobic monomer NCHO and 0.5 part of norbornene-based hydrophilic monomer NTEG containing triethylene glycol structure in 0.25 and 5 parts of dry dichloromethane, respectively ;

[0041] (2) the 3rd generation catalyst of 0.01 part of Grubbs is dissolved in the flask that 0.3 part of dry dichloromethane is housed under nitrogen protection; Stir vigorously at room temperature and react under nitrogen protection for 20 minutes;

[0042] (3) Add the norbornene-based hydrophilic monomer solution containing triethylene glycol structure into the reaction system quickly, and further react vigorously at room temperature for 20 minutes; then inject 0.5 parts of vinyl ether into the flask to deactivate the catalyst, Diethyl ether was used to promote product precipitation, and the precipitate was collected by filtratio...

Embodiment 2

[0046] A preparation method of electrospun collagen fibers, comprising the following steps:

[0047] (1) Dissolve 0.05 parts of aldehyde-containing norbornene-based hydrophobic monomer NCHO and 1 part of norbornene-based hydrophilic monomer NTEG containing triethylene glycol structure in 0.5 and 10 parts of dry dichloromethane, respectively ;

[0048] (2) the 3rd generation catalyst of 0.015 part of Grubbs is dissolved in the flask that 0.4 part of dry dichloromethane is housed under nitrogen protection; Stir vigorously at room temperature and react under nitrogen protection for 10 minutes;

[0049] (3) Add the norbornene-based hydrophilic monomer solution containing triethylene glycol structure quickly into the reaction system, further react vigorously at room temperature for 10 minutes, then inject 0.5 parts of vinyl ether into the flask to deactivate the catalyst, Diethyl ether was used to promote product precipitation, and the precipitate was collected by filtration, com...

Embodiment 3

[0053] A preparation method of electrospun collagen fibers, comprising the following steps:

[0054] (1) Dissolve 0.04 parts of aldehyde-containing norbornene-based hydrophobic monomer NCHO and 0.8 parts of norbornene-based hydrophilic monomer NTEG containing triethylene glycol structure in 0.4 and 8 parts of dry dichloromethane, respectively ;

[0055] (2) the 3rd generation catalyst of 0.012 parts of Grubbs is dissolved in the flask that 0.32 parts of dry methylene chloride is housed under nitrogen protection; Stir vigorously at room temperature and react under nitrogen protection for 15 minutes;

[0056] (3) Add the norbornene-based hydrophilic monomer solution containing triethylene glycol structure quickly into the reaction system, further react vigorously at room temperature for 15 minutes, then inject 0.5 parts of vinyl ether into the flask to deactivate the catalyst, And use diethyl ether to promote the precipitation of the product, filter to take the precipitate, an...

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Abstract

The invention discloses a water-soluble cross-linking agent, its preparation method and the prepared electrospun collagen fiber. The preparation method of the cross-linking agent is as follows: (1) in a protective gas atmosphere, mix the aldehyde group-containing norbornene-based hydrophobic monomer solution with the catalyst solution, stir and react at room temperature for 10-20 minutes, and then add triglycerides Alcohol norbornene-based hydrophilic monomers, continue to stir and react at room temperature for 10-20 minutes; (2) Then add a reaction terminator to terminate the reaction, then add an organic reagent to precipitate the reactant, filter, and then purify and dry the solid phase product That's it. The crosslinking agent prepared by the invention can improve the stability of the collagen, so that the prepared electrospun collagen nanofibers can also have better structural stability and mechanical properties.

Description

technical field [0001] The invention belongs to the technical field of preparation of electrospun collagen fibers, and in particular relates to a water-soluble crosslinking agent, a preparation method thereof, and the prepared electrospun collagen fibers. Background technique [0002] Collagen is the main component of the extracellular matrix and the most abundant structural protein in animals. It has inherent advantages in the preparation of biomedical materials such as tissue engineering scaffolds and drug carriers. However, the thermal stability and mechanical properties of natural collagen are often difficult to meet the needs of practical applications. Certain modification methods are often used to endow collagen with better structural stability and functional properties. Among them, chemical crosslinking is one of the most effective means of modification. At present, the chemical cross-linking agents for collagen reported in the literature mainly include glutaraldehyd...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08F232/08D01F4/00D01F1/10
CPCC08F232/08D01F1/10D01F4/00
Inventor 刘文涛李培玉白聪辜海彬
Owner SICHUAN UNIV
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