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Furan ring compound in portulaca oleracea, extraction and separation method and application thereof

A separation method, the technology of purslane, applied in the direction of organic chemistry, drug combination, non-central analgesic, etc., can solve the problem of low structural novelty, and achieve the effect of environmentally friendly process method, simple and fast operation method

Active Publication Date: 2020-06-02
LIAONING UNIV OF TRADITIONAL CHINESE MEDICINE
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  • Abstract
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  • Application Information

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Problems solved by technology

[0004] At present, most of the chemical components isolated from purslane are known, and the structural novelty is low. Therefore, the development and isolation of new compounds in purslane are urgently needed

Method used

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  • Furan ring compound in portulaca oleracea, extraction and separation method and application thereof
  • Furan ring compound in portulaca oleracea, extraction and separation method and application thereof
  • Furan ring compound in portulaca oleracea, extraction and separation method and application thereof

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Experimental program
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Embodiment Construction

[0036] The present invention provides new compound, molecular formula is C 11 h 10 o 2 , the chemical structural formula is:

[0037]

[0038] The new compound is named 4-methyl-5-phenylfuran-2-ol according to the structure, and its common name is olerafuran. Table 1 is the NMR data of the new compound: 1 H-NMR with 13 C-NMR in DMSO.

[0039] The nuclear magnetic data of table 1 novel compound of the present invention

[0040] position δ C

type δ H mult.(J in Hz)

2 172.2 C 3 97.4 CH 6.53d(1.08) 4 124.1 C Me-C 4

9.9 2.00d(0.84) 5 154.9 C 1′ 131.1 C 2′ / 6′ 128.5 CH 7.62m 3′ / 5′ 128.7 CH 7.52m 4′ 129.7 CH 7.47m

[0041] olerafuran: yellow oil, easily soluble in methanol, slightly soluble in chloroform. UV(MeOH)λ max : 207.7, 273.5nm. UHPLC-ESI(+)-TOF-MS gave m / z: 175.0754, [M+H] + The quasi-molecular ion peak has a molecular weight of 174.1990. combine 1 H-NMR, 1...

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Abstract

The invention relates to the field of extraction and separation of traditional Chinese medicines, in particular to a new compound extracted, separated and identified from a portulaca oleracea medicinal material, an extraction and separation method and application thereof, and particularly relates to an extraction and separation method and application of a furan ring compound in portulaca oleracea.The extraction and separation method of the new compound sequentially adopts ethanol extraction, silica gel column chromatography, polyamide column chromatography, macroporous resin column chromatography, ODS medium-pressure column and Sephadex LH-20 purification, and liquid phase separation for preparation. The structure of the compound is determined as a new furan ring compound by adopting UHPLC-ESI-TOF-MS, <1>H-NMR, <13>C-NMR and two-dimensional nuclear magnetic spectrum analysis method. The compound has potential anti-inflammatory and neuroprotective effects and other activities, the newcompound and salts or derivatives thereof can be used as other compound synthesis primers and raw materials for new drug development and pharmacological activity research, and the primer and theoretical basis are provided for new drug development and new component development.

Description

technical field [0001] The invention relates to the field of extraction and separation of traditional Chinese medicines, in particular to a new compound extracted, separated and identified from purslane medicinal material and its extraction and separation method, specifically a method for extraction and separation of a furan ring compound in purslane and its application . Background technique [0002] Purslane (Portulaca oleracea L.), also known as longevity dish, horse amaranth, is a plant of the family Amaranthaceae. Purslane is drought and waterlogging resistant, light and shade resistant, widely distributed, and rich in resources. It has attracted much attention as a wild plant for both medicine and food. The 2015 edition of "Pharmacopia of the People's Republic of China" recorded the dry aerial parts of purslane as medicine. , has the functions of clearing away heat and detoxification, cooling blood to stop bleeding, and stopping dysentery. [0003] Modern pharmacolog...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D307/58A61P29/00A61P25/00
CPCC07D307/58A61P29/00A61P25/00
Inventor 英锡相刘锡龙张文洁
Owner LIAONING UNIV OF TRADITIONAL CHINESE MEDICINE
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