Application of zogta in preparation of drugs for enhancing anticancer activity of daunorubicin in vivo and in vitro

A technology of daunorubicin and anticancer activity, applied in the field of drug preparation, can solve the problems of increasing drug dose, reducing curative effect, failure of chemotherapy, etc., and achieve the effect of promoting enrichment, promoting apoptosis rate, and increasing drug concentration

Pending Publication Date: 2020-05-22
CHINA ACAD OF SCI NORTHWEST HIGHLAND BIOLOGY INST
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, daunorubicin also has relatively large toxic and side effects when killing tumor cells.
Moreover, with the progress of chemotherapy, many tumor cells can develop resistance to chemotherapy drugs and reduce the curative effect. Multidrug resistance has become the main reason for the final failure of chemotherapy in cancer patients.
Increasing the drug dose will bring more toxic and side effects to patients, so seeking ways, adjuvants or methods that can effectively increase the drug concentration at the tumor site is one of the hotspots in the field of tumor treatment.

Method used

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  • Application of zogta in preparation of drugs for enhancing anticancer activity of daunorubicin in vivo and in vitro
  • Application of zogta in preparation of drugs for enhancing anticancer activity of daunorubicin in vivo and in vitro
  • Application of zogta in preparation of drugs for enhancing anticancer activity of daunorubicin in vivo and in vitro

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] 1. Zotai promotes the entry of daunorubicin into cells

[0025] 1.1 Administration method

[0026] Grouping and administration: K562 leukemia cells, HN4 oral squamous cell carcinoma epithelial cells and HpG2 liver cancer cells were divided into daunorubicin alone 24h, 48h and 72h administration groups and daunorubicin combined with Zotai 24h, 48h and 72h administration group.

[0027] 1.2 Sample collection: Take K562 leukemia cells in logarithmic growth phase, HN4 oral squamous cell carcinoma epithelial cells and HpG2 liver cancer cells, and adjust the cell density to 2×10 6 Inoculated in Petri dishes respectively, placed in 5% CO 2 1. Cultivate in an incubator at 37°C until the cells grow to 70-80%. The three kinds of cells were treated with daunorubicin at a concentration of 0.25 μg / ml and Zotai combined with daunorubicin at a concentration of 5 ng / ml, washed three times with PBS after 24h, 48h, and 72h, and the cells were collected respectively.

[0028] 1.3 Samp...

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Abstract

The invention relates to application of zogta in preparation of drugs for enhancing the anticancer activity of daunorubicin in vivo and in vitro, belonging to the technical field of drug preparation.The invention provides the application of the zogta in preparation of the drugs for enhancing the anticancer activity of the daunorubicin in vivo and in vitro. According to the invention, a daunorubicin anticancer monomer drug is combined with zogta nanoparticles for in-vitro administration, which proves that the zogta can promote enrichment of the daunorubicin in different cancer cells. Meanwhile, the apoptosis promoting effect of the drugs can be enhanced.

Description

technical field [0001] The invention relates to the technical field of drug preparation, in particular to the application of Zotai in the preparation of drugs for enhancing the anticancer activity of daunorubicin in vivo and in vitro. Background technique [0002] Daunorubicin is an anthracycline antineoplastic drug, and it is currently a chemotherapy drug widely used in hematological tumors and various solid tumors. However, daunorubicin also has relatively large toxic and side effects when killing tumor cells. Moreover, with the progress of chemotherapy, many tumor cells can develop resistance to chemotherapy drugs and reduce the curative effect. Multidrug resistance has become the main reason for the final failure of chemotherapy in cancer patients. Increasing the drug dose will bring more toxic and side effects to patients, so seeking ways, adjuvants or methods that can effectively increase the drug concentration at the tumor site is one of the research hotspots in the ...

Claims

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Application Information

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IPC IPC(8): A61K47/02A61K31/704A61K33/28A61P35/00
CPCA61K47/02A61K31/704A61K33/28A61P35/00A61K2300/00
Inventor 赵晓辉张婷岳会兰周国英魏立新陶吉红贾文静
Owner CHINA ACAD OF SCI NORTHWEST HIGHLAND BIOLOGY INST
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