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A microwave-assisted extraction-gas chromatography-mass spectrometry method for the determination of allergenic fragrances in watercolor pens and highlighters

A gas chromatography-mass spectrometry and microwave-assisted technology, which is applied in the field of microwave-assisted extraction-gas chromatography-mass spectrometry for the determination of sensitized fragrances in watercolor pens and highlighters, can solve the problems of difficult qualitative and quantitative detection of fragrances, and improve the degree of separation. As well as detection sensitivity, good adaptability

Active Publication Date: 2020-09-22
SHANDONG INST FOR PROD QUALITY INSPECTION
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

At present, there is no research report on the detection method of allergenic fragrances for stationery products, and it is difficult to achieve qualitative and quantitative detection of some fragrances

Method used

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  • A microwave-assisted extraction-gas chromatography-mass spectrometry method for the determination of allergenic fragrances in watercolor pens and highlighters
  • A microwave-assisted extraction-gas chromatography-mass spectrometry method for the determination of allergenic fragrances in watercolor pens and highlighters
  • A microwave-assisted extraction-gas chromatography-mass spectrometry method for the determination of allergenic fragrances in watercolor pens and highlighters

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Experimental program
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Effect test

Embodiment 1

[0028] (1) Weigh the ink in 2g of the pen core into a 100mL microwave digestion tank, add 50mL of a mixed solvent composed of acetone and n-hexane according to the volume ratio of 1:1 for microwave extraction, and the conditions for microwave-assisted extraction are: microwave power 600W, The temperature was heated to 60°C for 2 minutes, kept for 1 minute, and then heated to 90°C for 2 minutes for extraction with microwave-assisted extraction for 15 minutes;

[0029] (2) After the extraction, take out the digestion tank, transfer the extract to a 150mL flat-bottomed flask, evaporate to 5mL by rotary evaporation, add 5mL of n-hexane, continue to evaporate to 5mL, repeat three times; add 5g of anhydrous sodium sulfate to remove moisture, and obtain The extract to be tested;

[0030] (3) Wash the commercially available magnesium silicate purification column with 5ml of dichloromethane, then add 5ml of n-hexane twice, until the liquid level reaches the sieve plate, close the contr...

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Abstract

The invention belongs to the technical field of detection, and particularly relates to a method for determining sensitizing aromatics in a water color pen and a highlighter through microwave-assistedextraction-gas chromatography-mass spectrometry. The method specifically comprises the following steps: weighing printing ink, adding a mixed solvent, and carrying out microwave-assisted extraction; carrying out rotary evaporation after the reaction is finished, and removing moisture to obtain an extracting solution; eluting by using a commercial magnesium silicate purification column, concentrating the collected liquid by using a nitrogen blowing instrument, and adding an internal standard solution and n-hexane to a constant volume to obtain a sample to be detected; preparing a standard solution to obtain a standard curve; and detecting the to-be-detected sample by adopting a gas chromatography-mass spectrometry method. The method provided by the invention can be used for simply, quickly,accurately and highly sensitively determining 40 kinds of sensitizing aromatics in the water color pen and the highlighter at the same time; through microwave-assisted extraction, sufficient dissolution of a to-be-detected substance in the to-be-detected substance can be improved, an internal standard method is adopted, the separation degree and the detection sensitivity of an analyte are remarkably improved, and the method is good in adaptability.

Description

technical field [0001] The invention belongs to the technical field of detection, and in particular relates to a microwave-assisted extraction-gas chromatography mass spectrometry method for measuring allergenic fragrances in watercolor pens and highlighters. Background technique [0002] Fragrances are a class of substances that are widely used in the daily chemical and consumer product industries. The various aromas it produces can make consumers feel happy about products, increase the attractiveness of products and consumers' desire to buy. At present, there are as many as 5,000 kinds of chemical substances that can be used in flavors and fragrances, some of which can have a strong stimulating effect on the human body through inhalation or skin contact, and cause people to have allergic reactions. Such substances are called allergenic fragrances. The EU Regulation 2009 / 48 / EC stipulates the types and limits of allergenic fragrances in toys and school supplies manufacture...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N30/02G01N30/06
CPCG01N30/02G01N30/06G01N2030/062
Inventor 熊大伟李桂晓吴恩凯彭晓辉韩凤云
Owner SHANDONG INST FOR PROD QUALITY INSPECTION
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