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Method for preparing precise liquid medicine filtering membrane through local coating and precise liquid medicine filtering membrane

A technology of liquid medicine and filter membrane, applied in the field of bacteria and virus filtration and particles, to achieve high structural strength, reduce flow resistance, and meet the requirements of ultrafiltration filtration

Inactive Publication Date: 2020-05-19
常州费曼生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The above common filter pore processing techniques are relatively easy for large pore sizes, but very challenging for small pore sizes

Method used

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  • Method for preparing precise liquid medicine filtering membrane through local coating and precise liquid medicine filtering membrane
  • Method for preparing precise liquid medicine filtering membrane through local coating and precise liquid medicine filtering membrane

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0049] The porous anodic aluminum oxide AAO filter membrane with the original filter hole diameter of 250 nanometers, through the method of the present invention, the coating body 4 that is converted into a 100 nanometer filter hole is a precise medicinal solution filter membrane of aluminum oxide, specifically comprising the following steps:

[0050] (1) Select a porous anodic aluminum oxide AAO filter membrane with a pore size of 250 nanometers as the sample, clean and dry the sample;

[0051] (2) The sample is put into the electron beam evaporation coating equipment. The voltage of the electron gun is 5kV, and the target material is made of metal aluminum;

[0052] (3) According to the requirements of shrinkage cavity of the filter membrane, a 1-4 micron thick metal coating is deposited on the surface of the filter membrane until the pore diameter at the top of the filter hole is reduced to 100 nanometers;

[0053] (4) After the electron beam evaporation coating is complet...

Embodiment 2

[0055] The porous anodic aluminum oxide AAO filter membrane with the original filter hole diameter of 90 nanometers is converted into a precision medicinal solution filter membrane with 50 nanometer filter holes and the coating body 4 is silicon oxide by the method of the present invention, comprising the following steps:

[0056] (1) Select a porous anodic aluminum oxide AAO filter membrane with a pore size of 50 nanometers as the sample, clean and dry the sample;

[0057] (2) The sample is put into the plasma enhanced chemical strong deposition PECVD equipment.

[0058] (3) According to the requirements of shrinkage of the filter membrane, deposit 1-4 micron thick silicon oxide on the surface of the filter membrane until the pore diameter at the top of the filter hole is reduced to 50 nanometers.

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Abstract

The invention discloses a method for preparing a precise liquid medicine filtering membrane through local coating and the precise liquid medicine filtering membrane. The method comprises the steps that a liquid medicine filtering membrane with filtering holes is provided, and a partition wall is formed between every two adjacent filtering holes; local coating is conducted on at least one side of the liquid medicine filtering membrane with a non-conformal deposition coating method, so that a coating body is deposited on the corresponding side of each partition wall, and then the precise liquidmedicine filtering membrane undergoing hole shrinkage is obtained, wherein the coating bodies are at least transversely generated in the deposition process to enable the hole diameter of the corresponding sides of the filtering holes close to the coating bodies to be reduced. Local coating is adopted to adjust and control the hole diameter of the corresponding sides of the filtering holes, the technology is simple, after hole shrinkage, the hole diameter can reach 20 nanometers, and the virus filtering requirement and other filtering requirements can be met; and since only a part of the hole diameter of the filtering holes is reduced, the flow resistance of the filtering holes is reduced beneficially.

Description

technical field [0001] The invention relates to a method for preparing a precision liquid medicine filter membrane by partial coating and the precision medicine liquid filter membrane, belonging to the field of particle, bacteria and virus filtration in medical equipment and medicine production. Background technique [0002] During the production, transportation and use of the liquid medicine, the safety of the liquid medicine needs to be strictly controlled. In the process of use, the drug solution entering the vein through the infusion set needs to strictly control the particle pollution and possible bacterial contamination in the drug solution. For example, for infants and young children, due to the immature blood vessel development, the diameter of the blood vessel is small, so in the process of infusion therapy, once particle pollution and blockage occur, it is very likely to seriously endanger life safety. The national standard GB8368 (2005) clearly stipulates the par...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C23C14/30C23C14/04C23C14/18C23C14/58C23C16/40C23C16/50C23C16/04A61M5/165
CPCA61M5/165A61M2005/1657C23C14/04C23C14/185C23C14/30C23C14/5806C23C14/5853C23C16/04C23C16/402C23C16/50
Inventor 蒋开朱学林
Owner 常州费曼生物科技有限公司
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