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Compound preparation for treating skin inflammation and preparation method thereof

A compound preparation and skin inflammation technology, applied in the fields of Uyghur medicine and ethnic medicine, can solve the problems of telangiectasia, aggravation of symptoms, skin atrophy, etc., and achieve the effects of not easy recurrence, no drug resistance, and quick effect.

Active Publication Date: 2020-05-19
XINJIANG TECHN INST OF PHYSICS & CHEM CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At this stage, external use of glucocorticoids is usually used for the treatment of patients with eczema and dermatitis, but long-term application can easily lead to skin atrophy and promote telangiectasia, which will aggravate symptoms and may induce infection. Therefore, in terms of clinical effects and adverse reactions Considering other aspects, the advantages of using traditional Chinese medicine for the treatment of eczema and dermatitis patients are obvious.

Method used

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  • Compound preparation for treating skin inflammation and preparation method thereof
  • Compound preparation for treating skin inflammation and preparation method thereof
  • Compound preparation for treating skin inflammation and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] (Based on preparing 1000g, prepare ointment)

[0033] Table 1

[0034]

[0035] a. According to the ratio in Table 1, crush Coptidis rhizome and Rheum rhubarb respectively to 40 mesh and mix, extract with 20 times the concentration of 70% ethanol at a temperature of 50°C, extract twice, each extraction time is 2 hours, and combine The extract is filtered to obtain an alcohol extract;

[0036] b. Grind gallons and roses separately to 100 mesh and mix them, extract with 15 times of water at a temperature of 50°C, extract twice, each extraction time is 2 hours, combine the extracts, filter to obtain water extracts liquid;

[0037] c. Concentrate the alcohol extract in step a and the water extract in step b under reduced pressure at a temperature of 40°C to an extract with a relative density of 1.05, dry in vacuum, and pulverize to obtain alcohol extract extract powder and water extract extract pink;

[0038] d, the alcohol extraction extract powder in step c is mixe...

Embodiment 2

[0041] (Based on preparing 1000g, prepare ointment)

[0042] a. According to the ratio in Table 1, crush Coptidis rhizome and Rheum officinalis respectively to 100 mesh and mix them, and extract them with 8 times concentration of 70% ethanol at a temperature of 100° C., extract 3 times, and the extraction time is 1.5 hours, and combine the extracts , filtered to obtain alcohol extract;

[0043] b. Grind gall and rose respectively to 10 meshes and mix, extract with 8 times the amount of water at 100°C, extract 3 times, each extraction time is 1.5 hours, combine the extracts, filter to obtain water extract liquid;

[0044] c. Concentrate the alcohol extract in step a and the water extract in step b under reduced pressure at a temperature of 60° C. to an extract with a relative density of 1.10 to obtain an alcohol extract and a water extract;

[0045] d, the alcohol extraction extract in step c is mixed with propylene glycol to make solution A for subsequent use;

[0046] e. T...

Embodiment 3

[0048] (Based on the preparation of 1000g, the gel is prepared)

[0049] Table 2

[0050]

[0051] a. According to the ratio in Table 2, crush Coptidis rhizome and Rheum rhizoma to 100 mesh respectively, mix well, and extract with 5 times concentration of 50% ethanol at a temperature of 30°C, and extract twice, each extraction time is 2 hours , combined extracts, filtered to obtain alcohol extracts;

[0052] b. Gallats and roses are crushed to 100 meshes respectively, fully mixed, extracted with 5 times the amount of water, the temperature is 30°C, extracted twice, each extraction time is 2 hours, the combined extracts are filtered to obtain water extract;

[0053] c. Concentrating the alcohol extract in step a and the water extract in step b at a temperature of 60° C. under reduced pressure to obtain extracts with a relative density of 1.10 to obtain alcohol extracts and water extracts;

[0054] d, the alcohol extraction extract in step c is mixed with propylene glycol ...

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Abstract

The invention relates to a compound preparation for treating skin inflammation and a preparation method thereof. Raw materials of the preparation are coptis roots, nepal dock roots, rose flowers and gallnut. The raw materials are prepared into ointment, gel, tincture, film coating agents or liniments by solvent extraction, impurity removal, and concentration or drying with medical acceptable auxiliary materials. The compound preparation has antibacterial, antiinflammatory, and astringent effects, and can be used for treating skin inflammation comprising acute and chronic eczema, atopic dermatitis, contact dermatitis, and allergic dermatitis. Pharmacodynamic research shows that the compound preparation effectively inhibits NO activity, can inhibit NO release, and can obviously reduce inflammation degree of skin lesions. Through increase of the levels of IL-2, IL-4 and IL-18 reduced by dermatitis and eczema, and reduction of the levels of TNF-alpha and IL-12 increased by dermatitis and eczema, balance of Th1 cells and Th2 cells is achieved, and a treatment role is exerted.

Description

technical field [0001] The invention relates to a compound preparation for treating skin inflammation and a preparation method thereof, especially the application in preparing a compound medicine for treating eczema, and belongs to the technical field of Uighur medicine and ethnic medicine. Background technique [0002] Eczema is a skin inflammatory reaction with severe itching caused by various internal and external factors. Divided into acute, subacute and chronic stages. In the acute phase, it tends to exudate, while in the chronic phase, it is infiltrating and hypertrophic. Some patients directly show as chronic eczema. The skin lesions are characterized by pleomorphism, symmetry, itching, and recurrent attacks. Modern research has found that the etiology of eczema is related to genetic factors, blood circulation disorders, mental factors, metabolic factors, environmental factors (air, pollen, etc.), diet and bacterial infection. Its pathogenesis is complex, mainly re...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/738A61P17/00A61P37/08A61P29/00A61K35/64
CPCA61K36/718A61K36/70A61K36/738A61K35/64A61K9/0014A61K47/32A61K47/06A61P17/00A61P37/08A61P29/00A61K2236/333A61K2236/39A61K2236/331A61K2236/51A61K2300/00
Inventor 阿吉艾克拜尔·艾萨凯丽比努尔·艾尔肯吴涛贺飞西尔艾力·吐尔逊
Owner XINJIANG TECHN INST OF PHYSICS & CHEM CHINESE ACAD OF SCI
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