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A kind of preparation method and application of chitosan plga nano-flavor

A technology of chitosan and essence, which is applied in the direction of microsphere preparation, essential oil/fragrance, microcapsule preparation, etc. It can solve the problems of unsatisfactory, large particle size of microcapsule essence and low loading capacity, and achieve high loading capacity, Good biocompatibility, high safety effect

Active Publication Date: 2022-07-12
SHANGHAI INST OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

On the other hand, the microcapsule essence cannot meet people's needs to a certain extent due to its large particle size and low loading capacity.

Method used

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  • A kind of preparation method and application of chitosan plga nano-flavor

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Embodiment 1

[0028] The present embodiment provides a preparation method of chitosan PLGA nano-sweet orange flavor, the specific steps are as follows:

[0029] Step 1: respectively accurately weigh 100mg PLGA (lactic acid: glycolic acid=75:25) and 100mg sweet orange essence and dissolve them in 5mL of ethyl acetate solution successively as oil phase;

[0030] Step 2: configure 1% glacial acetic acid solution as the solvent of the water phase; accurately weigh 0.1 g of chitosan and dissolve it in 10 mL of 1% glacial acetic acid solution to prepare a chitosan solution; accurately weigh 1 g of polyvinyl alcohol, which is easily soluble in 9mL of chitosan solution as water phase;

[0031] Step 3: Add the water phase obtained in step 2 into a glass reagent bottle with a lid, and use a magnetic stirrer to continue stirring at 800 rpm / min at room temperature; use a micro syringe pump to add the oil phase obtained in step 1 to 0.5mL / min. The speed of min is slowly injected into the water phase, w...

Embodiment 2

[0034] The present embodiment provides a preparation method of chitosan PLGA nano-sweet orange flavor, the specific steps are as follows:

[0035] Step 1: respectively accurately weigh 200mg PLGA (polylactic acid: glycolic acid = 75:25) and 200mg sweet orange essence and dissolve them in 5mL of ethyl acetate solution successively as oil phase;

[0036] Step 2: configure 1% glacial acetic acid solution as the solvent of the water phase; accurately weigh 0.1 g of chitosan and dissolve it in 10 mL of 1% glacial acetic acid solution to prepare a chitosan solution; accurately weigh 1 g of polyvinyl alcohol, which is easily soluble in 9mL of chitosan solution as water phase;

[0037] Step 3: Add the water phase obtained in step 2 into a glass bottle with a lid, and use a magnetic stirrer to continue stirring at room temperature at 800 rpm / min; use a micro-syringe pump to stir the oil phase obtained in step 1 at 0.5 mL / min Slowly inject into the water phase at a speed of 10:1, where...

Embodiment 3

[0040] The present embodiment provides a preparation method of chitosan PLGA nano-lily of the valley flavor, the specific steps are as follows:

[0041] Step 1: Accurately weigh 100 mg PLGA (lactic acid: glycolic acid=75:25) and 100 mg lily of the valley essence and dissolve them in 5 mL of ethyl acetate solution as oil phase;

[0042] Step 2: configure 1% glacial acetic acid solution as the solvent of the water phase; accurately weigh 0.1 g of chitosan and dissolve it in 10 mL of 1% glacial acetic acid solution to prepare a chitosan solution; accurately weigh 1 g of polyvinyl alcohol, which is easily soluble in 9mL of chitosan solution as water phase;

[0043] Step 3: Add the water phase obtained in step 2 into a glass bottle with a lid, and use a magnetic stirrer to continue stirring at room temperature at 800 rpm / min; use a micro-syringe pump to stir the oil phase obtained in step 1 at 0.5 mL / min Slowly inject into the water phase at a speed of 10:1, wherein the volume ratio...

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Abstract

The invention provides a preparation method of chitosan PLGA nano-flavor and a preparation method of humidity-responsive PLGA nano-sweet orange flavor-flavored paper. Dissolve PLGA and sweet orange essence in ethyl acetate as the oil phase; dissolve chitosan and polyvinyl alcohol in distilled water as the water phase; slowly drop the oil phase into the water phase under mechanical stirring and continue stirring to form The mixed solution is ultrasonically emulsified by a cell disrupter under ice bath conditions to form a uniform emulsion, ethyl acetate is removed, and the nano-flavor is evenly sprayed on the upper part of the to-be-flavored paper to obtain a fragranced paper. At the same time, adding HY-4021 lotus leaf hydrophobic agent can effectively control the water absorption rate of perfumed paper in a humid environment. When it is applied to a humid environment, the hydrolysis rate of PLGA is different under different humidity conditions, and the PLGA is slowly released and embedded in the nanoparticles. The sweet orange essence can achieve the purpose of long-acting and slow-release. The nano-flavor prepared by the invention has a high loading capacity, can be used for the perfuming research of different flavors, has better sustained-release effect and wide applicability.

Description

technical field [0001] The invention belongs to the field of fine chemicals, and in particular relates to a chitosan PLGA nano-flavor and a preparation method and application thereof. Background technique [0002] Flavored paper is a functional paper prepared by adding spices, essences or other flavored products, which can continue to emit fragrance for a period of time on the basis of not affecting the basic performance of the flavored paper. With the improvement of people's quality of life and the enhancement of consumers' awareness of environmental protection, biodegradable materials have huge application space. [0003] Essence is deeply loved by consumers because of its special fragrance, but the essence contains a large amount of terpenes and polyphenols, which are easily affected by environmental factors such as temperature, humidity and pH. Good solution to this problem. On the other hand, microcapsule flavor cannot meet people's needs to a certain extent due to it...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08L29/04C08L5/08C08L67/04C08K5/00D21H19/10D21H21/14C11B9/00B01J13/02
CPCC08L29/04D21H19/10D21H21/14C11B9/00B01J13/02C08L2205/03C08L5/08C08L67/04C08K5/00Y02W90/10
Inventor 肖作兵万帅寇兴然牛云蔚
Owner SHANGHAI INST OF TECH
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