A kind of rosemary essential oil nano liposome and its preparation method and application

A technology of rosemary essential oil and nano-liposomes, which is applied in liposome delivery, pharmaceutical formulations, medical preparations of non-active ingredients, etc., can solve the problems of liposomes lack of viscosity and thixotropy, and achieve increased retention Quantity and retention time, good sustained-release effect, and the effect of using less reagents

Active Publication Date: 2021-11-26
河南德盟医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, as an external preparation, liposomes lack certain viscosity and thixotropy, which are very necessary properties for external preparations.

Method used

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  • A kind of rosemary essential oil nano liposome and its preparation method and application
  • A kind of rosemary essential oil nano liposome and its preparation method and application
  • A kind of rosemary essential oil nano liposome and its preparation method and application

Examples

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Effect test

Embodiment 1

[0032] A preparation method of rosemary essential oil nano liposome, the method comprises the following steps:

[0033] (1) Take the fresh leaves of rosemary and dry them in the shade, then place them in water for steam distillation to extract the essential oil, the mass ratio of dry rosemary leaves to water is 1:10 during extraction, and distill and extract for 3 hours;

[0034] (2) dissolving rosemary essential oil in caprylic triglyceride and mixing uniformly to obtain the first mixture; wherein the mass ratio of rosemary essential oil to capric triglyceride is 1:35;

[0035] (3) Dissolve the poloxamer melted at 70°C in deionized water and mix evenly, then let it stand for 24 hours, and stir it fully after standing to obtain the second mixture; the amount of melted poloxamer and deionized water The ratio is 3g: 16ml;

[0036] (4) The second mixture is continuously and slowly added to the first mixture (mixing with the mass ratio of rosemary essential oil and molten poloxam...

Embodiment 2

[0039] A preparation method of rosemary essential oil nano liposome, the method comprises the following steps:

[0040] (1) Take the fresh leaves of rosemary and dry them in the shade, then place them in water for steam distillation to extract the essential oil, the mass ratio of the shade-dried rosemary leaves to water is 1:14, and distill and extract for 3.5 hours;

[0041] (2) dissolving rosemary essential oil in caprylic triglyceride and mixing uniformly to obtain the first mixture; wherein the mass ratio of rosemary essential oil to capric triglyceride is 1:50;

[0042] (3) Dissolve the poloxamer melted at 70°C in deionized water and mix evenly, then let it stand for 24 hours, and stir it fully after standing to obtain the second mixture; the amount of melted poloxamer and deionized water The ratio is 3g: 40ml;

[0043](4) The second mixture is continuously and slowly added to the first mixture (mixed with a mass ratio of rosemary essential oil and molten poloxamer of 1:...

Embodiment 3

[0046] A preparation method of rosemary essential oil nano liposome, the method comprises the following steps:

[0047] (1) Take the fresh leaves of rosemary and dry them in the shade, then place them in water for steam distillation to extract the essential oil, the mass ratio of the shade-dried rosemary leaves to water is 1:12, and distill and extract for 3 hours;

[0048] (2) dissolving rosemary essential oil in caprylic triglyceride and mixing uniformly to obtain the first mixture; wherein the mass ratio of rosemary essential oil to capric triglyceride is 1:42;

[0049] (3) Dissolve the poloxamer melted at 70°C in deionized water and mix evenly, then let it stand for 24 hours, and stir it fully after standing to obtain the second mixture; the amount of melted poloxamer and deionized water The ratio is 3g: 28ml;

[0050] (4) The second mixture is continuously and slowly added to the first mixture (mixed with the mass ratio of rosemary essential oil and molten poloxamer as 1...

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PUM

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Abstract

The invention discloses a rosemary essential oil nano liposome, a preparation method and application thereof. First, dissolve rosemary essential oil in caprylic triglyceride and mix well; then dissolve the melted poloxamer in deionized water, let it stand, and then stir well; mix the above two mixtures and put them under high pressure Processing is carried out in a homogenizer, and after the processing is completed, the temperature is lowered to below 24° C. to obtain rosemary essential oil nano liposomes. The rosemary essential oil nano-liposome prepared by the invention overcomes the defects existing in the use process, has better slow-release effect, and makes it better exert its pharmacological activity. And under the effect of liposome's better penetration-promoting effect and better biological viscosity, the retention amount and retention time of the drug in the skin are increased, and the local effect of the drug is better exerted. The method is simple and easy, requires less reagents, and has low preparation cost, and the obtained rosemary essential oil nano-liposome has a high coating rate, and has good application prospects.

Description

technical field [0001] The invention relates to the application of rosemary essential oil, in particular to a nano liposome of rosemary essential oil and its preparation method and application. Background technique [0002] Rosemary, also known as the dew of the ocean, belongs to the subshrub of the genus Rosmarinus or the perennial herbaceous plant of the family Lamiaceae. Rosemary essential oil contains more carnosol, carnosic acid, rosmarinic acid and ferulic acid and other diterpene phenolic antioxidant components, all of which contain unsaturated double bonds and phenolic hydroxyl groups , phenolic acidic substances have strong reducibility, and have a good scavenging effect on oxidative substances, and within a certain range, with the increase of substance concentration, the higher the scavenging rate, it is the scavenging process of rosemary essential oil DPPH free radicals The main hero in. Therefore, rosemary extract has a good antioxidant effect, and has obvious ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/127A61K36/53A61K47/10A61K47/14A61P31/04
CPCA61K9/0014A61K9/1271A61K36/53A61K47/10A61K47/14A61K2236/331A61P31/04
Inventor 陈雅利黄海英
Owner 河南德盟医药科技有限公司
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