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Long-effective bacteriostatic gel dressing used for operative wounds and production method thereof

A long-acting, gel-based technology, applied in medical science, bandages, etc., can solve the problems of cell or tissue organ toxicity, insufficient mechanical strength, etc., and achieve good wound healing ability, strong toughness, and good air permeability

Active Publication Date: 2020-04-28
MUDANJIANG MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

First, its mechanical strength is still insufficient compared to fiber-type antibacterial dressings; second, although some antibacterial ingredients have strong antibacterial properties, they still have certain cell or tissue organ toxicity.

Method used

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  • Long-effective bacteriostatic gel dressing used for operative wounds and production method thereof
  • Long-effective bacteriostatic gel dressing used for operative wounds and production method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1-3 and comparative example 1-4

[0026] The product formulation of long-acting bacteriostatic gel dressing for surgical wound of the present invention is as shown in table 1. Wherein, the product formulation composition of Comparative Examples 1-4 is obtained by adjusting on the basis of Example 1.

[0027] Table 1. Concrete composition (percentage by weight, %) of long-acting bacteriostatic gel dressing for surgical wound

[0028]

[0029] The preparation method of the gel dressing in embodiment 1-3 comprises the following steps: (1) take each raw material component by weight ratio, polyvinyl alcohol, hydroxypropyl cellulose are dissolved in partly deionized water to form an aqueous solution , add glycerin and sorbitol, heat to 50°C in a water bath, stir and mix to fully dissolve each component to form a polymer solution; (2) add bacterial cellulose, calcium alginate, sodium phenytoin and nano-silver particles to the remaining Stir evenly in ionized water to form a drug solution; (3) add the drug solution ...

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Abstract

The invention belongs to the field of medical dressings, and particularly relates to a long-effective bacteriostatic gel dressing used for operative wounds and a production method thereof. The gel dressing comprises raw material components of bacterial cellulose, alginate, a phenytoin medicine, nano-silver particles, polyvinyl alcohol, hydroxypropyl cellulose, glycerin, sorbitol, deionized water and the like. By using the antibacterial active components of the phenytoin medicine, the nano-silver particles and the like in combination with the active components, for promoting wound healing, of the bacterial cellulose, the alginate and the like, the long-effective bacteriostatic gel dressing used for the operative wounds has a synergistic effect in the aspects of antisepsis, anti-inflammation, promotion of healing of the operative wounds and the like, and has the characters of being good in air permeability, high in water-retention rate, high in tenacity and the like, and through high energy ray irradiation sterilization, a gel product is clean and safe, and does not cause wound infection.

Description

technical field [0001] The invention belongs to the field of medical dressings, in particular to a long-acting antibacterial gel dressing for surgical wounds and a preparation method thereof. Background technique [0002] Surgical wound infection refers to the inflammatory reaction caused by the infection of pathogenic bacteria in the surgical wound, which is one of the common postoperative complications of surgical patients. Wound infection is common after general surgery, especially in gastrointestinal tract and other contaminated operations. The reproduction of its flora may lead to wound infection, which will affect the growth of granulation tissue, cause delayed wound healing, and even cause infection of organs and tissues. Injuries increase the suffering of patients and increase the cost of treatment. With the improvement of the level of surgery and the progress of nosocomial infection management, most surgical wounds can heal well, but affected by various factors, so...

Claims

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Application Information

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IPC IPC(8): A61L26/00
CPCA61L26/0004A61L26/0014A61L26/0023A61L26/0061A61L26/0066A61L26/008A61L2300/104A61L2300/204A61L2300/404C08L1/02C08L5/04C08L1/284C08L29/04
Inventor 柴方圆霍福英孙丽丽聂元文韩雪肖阳
Owner MUDANJIANG MEDICAL UNIV
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