Compound herba houttuyniae mixture and preparation method thereof

Abstract

The invention discloses a preparation method of a compound herba houttuyniae mixture. The mixture is prepared by using herba houttuyniae, radix scutellariae, radix isatidis, fructus forsythiae and flos lonicerae as main medicinal materials; and the method comprises the following steps: performing decoction, obtaining a clear paste, performing alcohol precipitation, performing water precipitation,and preparing the mixture. According to the compound herba houttuyniae mixture prescription and preparation process provided by the invention, through control of temperature during alcohol precipitation, adjustment of the pH value during water precipitation and addition of poloxamer during mixture preparation, the method can effectively increase the content of effective ingredients baicalin and forsythin, the content is better than that of a commercially available compound herba houttuyniae mixture, the stability of the finished product can also be greatly improved, and even after long-term storage, the mixture still has no precipitation.

Description

technical field [0001] The invention relates to the field of traditional Chinese medicine preparations, in particular to a compound Houttuynia mixture and a preparation method thereof. Background technique [0002] As a traditional Chinese medicine, compound Houttuynia mixture is recorded in the national drug standards. Its prescription composition is as follows: Houttuynia cordata 100g, Scutellaria baicalensis 25g, Radix isatidis 25g, Forsythia 10g, Honeysuckle 10g, Sucrose 60g, Honey 200g, Sodium benzoate 2g , Ethylparaben 0.5g; made: 1000ml; its preparation method is as follows: decoct the five-flavored medicinal materials of the aforementioned prescription amount with water twice, each time for 2 hours, combine the decoction liquid, filter, and concentrate the filtrate to relative density 1.18-1.20 (60°C-80°C) clear paste, add ethanol and ethanol to settle until the alcohol content is 70%, stir well, let stand for 24 hours, filter, recover ethanol from the filtrate under...

AI Technical Summary

Problems solved by technology

[0004] Adopt the preparation method of above-mentioned national drug standard, in production practice at present, mainly exist following technical deficiency: 1) the prepared compound Houttuynia cordata mixture is less stable, and the precipitation that produces when long-term placement can increase gradually, affects Drug efficacy and drug safety; 2) the content of active ingredients (such as baicalin, forsythin, etc.) in the prepared compound Houttuynia mixture is on the low side, which leads to slow onset of effect during clinical treatment and insufficient curative effect

[0006] The Chinese invention patent with the publication number CN 102429994A provides a sugar-free compound Houttuynia cordata mixture, which reduces the total sugar content by means of macroporous resin adsorption and separation, so as to solve the problem of inconvenient intake for diabetic patients

However, the disadvantage of this technical solution is that it does not solve the problem of increased sedimentation during long-term placement

However, it can be seen from the data in the table in the 22nd paragraph of the specification of this patent that the disadvantages of this technical solution are: ① the problem of low content of active ingredients (such as baicalin) is not solved; ② the pH of the finished compound Houttuynia mixture The value is 6.7, which does not meet the requirements of the Chinese Pharmacopoeia (the Chinese Pharmacopoeia 2015 version stipulates that the pH value should be 4.0 to 5.0)

However, the disadvantages of this technical solution are as follows: ① When the content of the active ingredients houttuyfonate and quercitrin increases, the ingredients in the liquid medicine are also more complicated, so precipitation is more likely to occur when placed for a long time; Add HCl in the sinking step to adjust the pH value to 2.0-4.0, and then add NaOH solution in the preparation step to adjust the pH value to 4.6-4.9. Although the pH value of the finished product meets the requirements of the Chinese Pharmacopoeia, NaCl precipitation due to acid-base neutralization The increase will affect the long-term storage stability of the finished compound Houttuynia mixture, so the problem of increased precipitation during long-term storage has not yet been solved

However, due to the huge difference in the dosage forms of dropping pills and mixtures, there is uncertainty about whether polyethylene glycol can be applied to mixtures

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