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Platelet drug delivery system for targeting tumors and improving radiotherapy sensitivity, and preparation method thereof

A platelet and sensitivity technology, which is applied in the direction of antineoplastic drugs, pharmaceutical formulations, medical preparations with non-active ingredients, etc., can solve the problems of affecting radiotherapy sensitivity and different therapeutic effects, and achieve the inhibition of oxidative phosphorylation of tumor cells , improve sensitivity, improve the effect of radiotherapy sensitization effect

Active Publication Date: 2020-04-24
SHEYANG RES INST OF NANJING UNIV
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Problems solved by technology

[0003] Radiotherapy is suitable for almost all tumors, but the therapeutic effects are not the same, and the oxygen content of tumor cells directly affects the sensitivity of radiotherapy

Method used

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  • Platelet drug delivery system for targeting tumors and improving radiotherapy sensitivity, and preparation method thereof
  • Platelet drug delivery system for targeting tumors and improving radiotherapy sensitivity, and preparation method thereof
  • Platelet drug delivery system for targeting tumors and improving radiotherapy sensitivity, and preparation method thereof

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Embodiment Construction

[0030] The present invention will be described in detail below in conjunction with specific embodiments.

[0031] The specific preparation process of the platelet drug-loaded system targeting tumors and improving radiotherapy sensitivity of the present invention is as follows:

[0032] 1. Preparation of Platelets

[0033] (1) SPF grade SD rats were anesthetized by intraperitoneal injection of 0.3 mL / kg body weight with 10% chloral hydrate solution, three-line positioning was used to determine the puncture site, blood was collected with a blood collection needle, and blood was collected with negative pressure in a blood collection tube.

[0034] (2) To separate platelets, blood and plasma samples were centrifuged at 100 g for 20 minutes at room temperature to separate red blood cells and white blood cells.

[0035] (3) The obtained platelets were centrifuged at 100 g for 20 minutes to remove remaining blood cells. PBS buffer containing 1 mM EDTA and 2 mM prostaglandin E1 (PGE...

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Abstract

The invention relates to a platelet drug delivery system for targeting tumors and improving radiotherapy sensitivity. The platelet drug delivery system is a rat platelet drug delivery system, and is amixture of mPEG-PCL modified atorvaquone, PEG modified nanogold and rat platelets, namely Ato-Au@Plt; and the tumor targeting is characterized in that the platelet drug delivery system adopts platelets as a carrier to realize in-vivo long circulation and tumor microenvironment targeted drug release, so the radiotherapy sensitivity of tumors is improved. The platelet carrier is activated through atumor microenvironment, and is deformed and aggregated to release a drug in a targeted manner; and the released drug can inhibit oxidative phosphorylation of tumor cells and solve hypoxia, and the drug and the nanogold have a synergistic effect, so that the sensitivity of tumors to radiotherapy is improved, and the radiotherapy treatment effect is further improved.

Description

technical field [0001] The present invention specifically relates to a drug-carrying system that targets tumors, improves radiotherapy sensitivity, and then improves radiotherapy treatment effect. Background technique [0002] Although a variety of anti-tumor drugs have been marketed at present, the anti-tumor effect is not satisfactory due to poor tumor targeting and poor accumulation ability in tumors. How to efficiently deliver anti-tumor drugs into tumors, increase the concentration of drugs in tumor sites, and reduce their concentrations in normal tissues has become a hot spot in the field of pharmaceutical research. [0003] Radiotherapy is suitable for almost all tumors, but the therapeutic effects are not the same, and the oxygen content of tumor cells directly affects the sensitivity of radiotherapy. Radiosensitization is an effective way to improve the effect of radiotherapy and reduce side effects. Radiotherapy sensitizers and solutions to tumor hypoxia can play...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K41/00A61K47/60A61K9/50A61K47/46A61K31/122A61P35/00
CPCA61K9/5068A61K41/0038A61K31/122A61K47/60A61P35/00A61K2300/00
Inventor 胡勇夏栋林罗星谕蒋炜张超
Owner SHEYANG RES INST OF NANJING UNIV
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