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Anticoccidial solution containing toltrazuril and preparation method thereof

A technology for toltrazuril and anti-coccidial, applied in the field of anti-coccidial solution and preparation thereof, can solve the problems of poor stability, low effective concentration, discoloration and the like of toltrazuril, and achieves fast dissolving speed, high effective concentration, The effect of maintaining stability

Inactive Publication Date: 2010-09-15
山东迅达康兽药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] At present, most of the listed products of toltrazuril are powders and drinking water preparations, the effective concentration of which is low, and the stability of toltrazuril is poor, and precipitation and discoloration are prone to occur

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0048] To produce 100L of anticoccidial solution containing toltrazuril, mix 75L polyethylene glycol 400 and 25L dimethyl sulfoxide and heat to 60°C, and add 2.5kg toltrazuril at a constant temperature of 60°C, the stirring speed 60-70 rev / min, stirring and dissolving to obtain an anticoccidial solution containing toltrazuril.

Embodiment 2

[0050] To produce 100L of anticoccidial solution containing toltrazuril, mix 75L of polyethylene glycol 400 and 25L of dimethyl sulfoxide, heat it to 60°C, and add 2.5kg of toltrazuril and 1.0kg of hemostatic solution at a constant temperature of 60°C Sensitive, stirring, the stirring speed is 60-70 rev / min, and after stirring evenly, an anticoccidial solution containing toltrazuril is obtained.

Embodiment 3

[0052] To produce 100L of anticoccidial solution containing toltrazuril, mix 70L of polyethylene glycol 400 and 30L of dimethyl sulfoxide and heat to 60°C, add 3.0kg of toltrazuril at a constant temperature of 60°C, stir, The stirring speed is 60-70 revolutions per minute, and the anticoccidial solution containing toltrazuril is obtained after stirring evenly.

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PUM

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Abstract

The invention discloses an anticoccidial solution containing toltrazuril and a preparation method thereof. The anticoccidial solution is prepared from toltrazuril, polyethylene glycol 400 and dimethyl sulfoxide. The preparation method comprises the following steps of: mixing the polyethylene glycol 400 and the dimethyl sulfoxide, heating the mixture to 60 DEG C, adding the toltrazuril at the constant temperature of 60 DEG C, and uniformly stirring the solution at 60 to 70 rpm to obtain the anticoccidial solution containing toltrazuril. Other medicaments also can be added into the anticoccidial solution containing toltrazuril to prepare a compound anticoccidial solution containing toltrazuril. In the technology of the invention, the PEG 400 and the dimethyl sulfoxide are used as the solvent; the heating manner at the constant temperature of 60 DEG is applied to dissolve the solution, so that the toltrazuril can not be damaged and has high effective concentration and high dissolution speed; the constant-temperature stirring manner at the speed of 60 to 70 rpm is beneficial to maintaining the stability of the toltrazuril solution, so that the quality of the toltrazuril solution is ensured.

Description

technical field [0001] The invention relates to an anticoccidial solution containing toltrazuril and a preparation method thereof, belonging to the technical field of veterinary drug solutions. Background technique [0002] Chicken coccidiosis (Coccidiosis in Chicken) is a common and very serious parasitic disease in chickens, and the economic loss it causes is staggering. The morbidity and mortality of chicks are high. The growth of the sick chicks is hindered, and the weight gain is slow; the adult chickens are mostly worm carriers, and the weight gain and egg production capacity are reduced. Especially in areas with high temperature and high humidity, it is conducive to the growth and development of coccidia oocysts, and it is often explosive. Coccidiosis often causes morbidity in 15-50 day-old chicks, and the mortality rate is as high as 80%. Most types of coccidia parasitize in the intestinal tract and cause intestinal lesions. [0003] There are 7 species of Eimeri...

Claims

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Application Information

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IPC IPC(8): A61K9/08A61K31/53A61K47/34A61K47/20A61K31/205A61K31/4164A61K31/122A61K31/635A61P33/02A61K47/10
Inventor 汪安国王尚明刘媛媛
Owner 山东迅达康兽药有限公司
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