Bioactive silicon regenerative medical material and preparation method thereof

Abstract

The invention relates to the field of novel biomedical materials, in particular to a bioactive silicon regenerative medical material and a preparation method thereof. The material comprises a scaffoldwhich is formed by accumulating nanoscale silicon dioxide particles and has a porous structure, and calcium and phosphorus elements which are uniformly distributed in the scaffold, and is a calcium phosphosilicate compound with biological activity, wherein the specific surface area is 200-350 m <2> / g; the material is prepared from the following components in percentage by mole: 28.5 to 81 percentof SiO2, 2.7 to 14.0 percent of P2O5 and 16.2 to 57.5 percent of CaO. The material is prepared from the following components in parts by weight: 25 to 75 parts of silicon dioxide sol, 5 to 15 parts of phosphate esters, 0.01 to 0.2 part of a surfactant, 15 to 50 parts of calcium-containing salt and 0.5 to 1.5 parts of a pH regulator. According to the method, the problems that a solvent is requiredto be used in the process of synthesizing the bioactive silicon regenerative medical material by taking tetraethoxysilane and the like as silicon precursors, the solvent is difficult to recover, theproduction period is long, and the corrosion of a catalyst to equipment is large are solved; in addition, the silicon dioxide sol with a large specific surface area is introduced, so that the bioactive silicon regenerative medical material with a larger specific surface area is synthesized, and the biological activity is stronger.

Description

technical field [0001] The invention relates to the field of biomedical new materials, in particular to a bioactive silicon regenerative medical material and a preparation method thereof. Background technique [0002] New bioactive materials have always been the focus of research in the field of medical materials. Compared with polymer medical materials that can cause rejection, and metal medical materials that can cause side effects such as thermal necrosis, inorganic non-metallic bioactive materials are relatively safe due to their high safety. more accepted by people. Among them, the research is relatively mature, relying on the stability of silicon and the development of inorganic silicon bioactive materials, including the traditional bioactive glass made by glass melting process; and the recently developed hydrolyzed organosiloxane, and Bioactive silicon materials manufactured by sol-gel process; the latter has become a research and development hotspot due to its more ...

AI Technical Summary

Problems solved by technology

[0003] The current sol-gel process is realized by using organic silicon raw materials such as hydrolyzed ethyl orthosilicate as the silicon precursor, but the hydrolysis process of ethyl orthosilicate has poor miscibility with water, and the hydrolysis process requires It is difficult to catalyze in an acidic environment or an alkaline environment; in order to increase its miscibility with water, alcohol reagents are generally used to pre-dissolve, thus increasing the cost of raw materials, and it is necessary to increase the recovery system of alcohol solvents, which increases equipment costs and Risk of environmental pollution; in the catalysis process, when acid catalysis is used, the acid will seriously corrode the equipment. The specific surface area of ​​the material is small

Images