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Degradable ureteral stent and manufacturing method thereof

A ureteral stent tube and technology of degradable materials, applied in the field of degradable ureteral stent tube and its production, can solve the problems of loss or even need to remove the kidney, bleeding and tissue damage, poor tissue compatibility, etc., and achieve good mechanical support performance, degradation The effect of prolonging the speed and improving the mechanical properties

Active Publication Date: 2020-04-14
SECOND AFFILIATED HOSPITAL OF XIAN MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The main components of the currently used ureteral stents are non-absorbable polyurethane, silicone rubber and metal materials, which need to be removed by surgery again after surgery, and have poor tissue compatibility, which is easy to form stones, infection, bleeding and tissue damage
If the stent is placed for a long time, it will cause serious consequences, such as the loss of renal function and even the need to remove the kidney
And a second surgery is required to remove the indwelling stent

Method used

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  • Degradable ureteral stent and manufacturing method thereof

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Effect test

Embodiment 1

[0036] Such as figure 1 As shown, the degradable ureteral stent tube in the present invention consists of a polycaprolactone outer membrane layer 1, a polyglycolide fiber and a polyglycolide-lactide fiber braided layer 2, L-lactide-ε- Caprolactone copolymer / graphene inner film layer 3 composition.

[0037] The graphene layer of the inner film layer 3 is a single-layer graphene with a thickness of 0.3 nm, and the thickness of each L-lactide-ε-caprolactone copolymer layer is 0.1 μm.

[0038] The preparation method of the inner film layer 3 includes: (1) attaching the L-lactide-ε-caprolactone copolymer solution to the graphene / copper sheet side with graphene by spin coating or casting, and dry it naturally 10h; then the copper sheet was etched in ammonium persulfate solution and etched for 8h at room temperature to obtain L-lactide-ε-caprolactone copolymer / graphene film; (2) L-lactide-ε -Transfer the caprolactone copolymer / graphene film to the surface of the graphene / copper sheet, s...

Embodiment 2

[0047] The degradable ureteral stent tube in the present invention is composed of polylactic acid outer membrane layer 1, polydioxanone fiber and polytrimethylene carbonate fiber braided layer 2, L-lactide-ε-caprolactone copolymer / Graphene inner film layer 3 composition.

[0048] The graphene layer of the inner film layer 3 is a single-layer graphene with a thickness of 0.4 nm, and the thickness of each L-lactide-ε-caprolactone copolymer layer is 1 μm.

[0049] The preparation method of the inner film layer 3 includes: (1) attaching the L-lactide-ε-caprolactone copolymer solution to the graphene / copper sheet side with graphene by spin coating or casting, and dry it naturally 10h; then the copper sheet was etched in ammonium persulfate solution and etched for 8h at room temperature to obtain L-lactide-ε-caprolactone copolymer / graphene film; (2) L-lactide-ε -Transfer the caprolactone copolymer / graphene film to the surface of the graphene / copper sheet, so that the L-lactide-ε-caprol...

Embodiment 3

[0058] The degradable ureteral stent tube of the present invention is composed of polyglycolide outer membrane layer 1, polyhydroxy fatty acid ester fiber and polylactic acid-glycolic acid copolymer fiber braided layer 2, L-lactide-ε-caprolactone Copolymer / graphene inner film layer 3 composition.

[0059] The graphene layer of the inner membrane layer 3 is a single-layer graphene with a thickness of 0.35 nm, and the thickness of each L-lactide-ε-caprolactone copolymer layer is 2 μm.

[0060] The preparation method of the inner film layer 3 includes: (1) attaching the L-lactide-ε-caprolactone copolymer solution to the graphene / copper sheet side with graphene by spin coating or casting, and dry it naturally 10h; then the copper sheet was etched in ammonium persulfate solution and etched for 8h at room temperature to obtain L-lactide-ε-caprolactone copolymer / graphene film; (2) L-lactide-ε -Transfer the caprolactone copolymer / graphene film to the surface of the graphene / copper sheet, ...

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Abstract

The invention discloses a degradable ureteral stent and a manufacturing method thereof, belongs to the technical field of medical catheters, and aims to solve the problem in the prior art that an existing ureteral stent cannot be absorbed by a human body and needs to be taken out in an operation. According to the technical scheme, the degradable ureteral stent comprises an outer membrane layer, awoven layer and an inner membrane layer which are made of degradable materials, and the woven layer is formed by weaving two different degradable materials. The degradable ureteral stent is composed of the inner membrane layer, the woven layer and the outer membrane layer which are made of different degradable materials, and by means of the difference of the thermal performance and the degradationspeed of the multi-component degradable materials, the overall mechanical performance of the degradable ureteral stent is improved, and the degradation speed is further increased.

Description

Technical field [0001] The invention relates to the technical field of medical catheters, in particular to a degradable ureteral stent tube and a manufacturing method thereof. Background technique [0002] Ureteral stent tubes are commonly used in urological operations such as upper urinary tract obstructive lesions, renal ureteral calculi, urinary tract trauma, upper urinary tract reconstruction, etc. The main function of the ureteral stent is to keep the ureter unobstructed and to drain urine into the bladder. [0003] The main components of the currently used ureteral stent tubes are non-absorbable polyurethane, silicone rubber and metal materials. They need to be removed surgically after the operation. The histocompatibility is poor and it is easy to form stones, infection, bleeding and tissue damage. If the stent tube is placed for a long time, it will cause serious consequences, such as loss of kidney function and even nephrectomy. And a second operation is required to remo...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L29/12A61L29/02A61L29/06A61L29/14
CPCA61L29/06A61L29/02A61L29/148A61L29/14C08L67/04
Inventor 倪锋惠鹏宇白艳郑亮
Owner SECOND AFFILIATED HOSPITAL OF XIAN MEDICAL UNIV
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