Rhizoma bletillae polysaccharide/bioglass temperature-sensitive gel and preparation method and application thereof

Abstract

The invention provides rhizoma bletillae polysaccharide / bioglass temperature-sensitive gel and a preparation method and application thereof. The gel preparation is prepared from the raw materials of rhizoma bletillae polysaccharide serving as a main drug, bioactive glass, a temperature-sensitive gel matrix poloxamer, stabilizer glycerol, a skin absorption enhancer DMSO, preservative ethylparaben and water for injection. The bletilla striata polysaccharide / bioglass is combined with the temperature-sensitive in-situ gel to be applied to treatment of diabetic foot ulcer. The gel is in a liquid state in vitro. After the gel is administrated to an ulcer wound surface, the gel is rapidly changed into a gel-like semisolid, so that the medicine can be retained on the ulcer surface for a long time.The special pathological environment of the wound surface is improved. The purpose of healing the wound surface is achieved by combining the repairing effects of bletilla striata polysaccharide and bioactive glass.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a polysaccharide / biological glass temperature-sensitive gel and a preparation method and application thereof. Background technique [0002] Diabetes can lead to serious complications in different systems, and 15%-25% of diabetic patients eventually develop chronic non-healing diabetic foot ulcers (diabetic foot ulcers, DFUs). DFUs are divided into ischemic type, neurological type, and mixed type. The neuropathy, microvascular and macrovascular lesions of the patient's foot lead to decreased arterial perfusion of the lower extremity, and foot microcirculation disorder causes ulcers and gangrene. It is the most common type of diabetes. One of the complications of the disease is mainly manifested as numbness, coldness, paresthesia, ulcer and gangrene formation of the patient's lower limbs, and the ulcer is difficult to heal after a long time and is prone to infection. ...

AI Technical Summary

Problems solved by technology

Once DFUs are formed, the risk of wound deterioration will further increase, and the risk of lower limb amputation is 40 times higher than that of normal people. According to statistics, more than 85% of amputations are caused by DFUs. DFUs have a great impact on the quality of life of patients, and even endanger their lives. , causing a heavy burden on patients' families and public health services

[0003] The clinical treatment of DFUs faces the following problems: ①Debridement (such as autolytic debridement, mechanical debridement, maggot biological debridement) can remove necrotic and infected tissues and stimulate the growth of new granulation tissue, but each debridement has its advantages and disadvantages. Physicians are not easy to grasp its adaptation and contraindications

② Vascular interventional therapy can effectively improve the blood perfusion of blood vessels in diabetic foot lower extremities, but there are also problems of vascular intimal hyperplasia, thrombosis and re-stenosis and occlusion in interventional therapy

③ Stem cell transplantation can regenerate blood vessels in ischemic limbs of diabetic foot patients, improve blood supply of the affected limbs, and promote ulcer wound healing. It has begun to have curative effects in foreign countries, but there are few domestic ones

At present, most of the research focuses on the use of biologically active substances (antibacterial agents, protein drugs, living cells, etc.) to promote the healing of diabetic wounds. The therapeutic products that have been developed rarely take into account the special pathological environment of diabetic wounds, and the therapeutic effect is still not good.

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