Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

New blood vessel construct implanted into subcutaneous tissue of subject and preparation method thereof

A technology of subcutaneous tissue and new blood vessels, applied in catheters, pharmaceutical formulations, drug delivery, etc., can solve problems such as graft wear, inflammation, bleeding, etc.

Active Publication Date: 2020-04-07
GUANGZHOU WOMEN AND CHILDRENS MEDICAL CENTER
View PDF10 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the longest duration of this method is about 5 years, and intrahepatic transplantation still has risks such as intrahepatic transplantation site bleeding, inflammation, graft wear and local fatty degeneration

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • New blood vessel construct implanted into subcutaneous tissue of subject and preparation method thereof
  • New blood vessel construct implanted into subcutaneous tissue of subject and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0045] A method for preparing a neovascular construct for implanting into subcutaneous tissue of a subject, comprising:

[0046] Weigh 1.2g of polymer material (L-polylactic acid, PLLA, molecular weight 48000Da), put it in a 30ml glass beaker, add 10ml of organic solvent (hexafluoroisopropanol) into the beaker, and fully dissolve it to obtain an electrospinning solution.

[0047]Use a pipette to transfer the electrospinning solution from the beaker into a special electrospinning storage syringe, install the electrospinning nozzle (22G), adjust the electrospinning flow rate to 3.0mL / h, the voltage to 18kV, and the distance between the nozzle and the receiving device The receiving device is a cylindrical stainless steel tube with an outer diameter of 1.8 cm, the rotating speed of the receiving device is adjusted to 800 rpm, and the nanofiber catheter is obtained by electrospinning for 28 hours. Cut the nanofiber catheter into corresponding long sections as required, put it into ...

Embodiment 2

[0049] This embodiment provides a preparation method for implanting a neovascular construct into the subcutaneous tissue of a subject, which is roughly the same as the preparation method provided in Example 1, except that the polymer material and the organic solvent are different, and the difference is as follows:

[0050] The polymer material is a polylactic acid glycolic acid copolymer obtained by copolymerization of lactic acid and glycolic acid with a molar ratio of 75:25;

[0051] The organic solvent is trifluoroethanol.

Embodiment 3

[0053] This embodiment provides a preparation method for implanting a neovascular construct into the subcutaneous tissue of a subject, which is roughly the same as the preparation method provided in Example 1, except that the polymer material and the organic solvent are different, and the difference is as follows:

[0054] The polymer material is polyglycolic acid;

[0055] The organic solvent is tetrahydrofuran.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
Outer diameteraaaaaaaaaa
Lengthaaaaaaaaaa
Thicknessaaaaaaaaaa
Login to View More

Abstract

The invention discloses a new blood vessel construct implanted into the subcutaneous tissue of a subject and a preparation method thereof, belonging to the technical field of high polymer materials. The new blood vessel construct is a nanofiber catheter prepared from a high polymer material in an electrostatic spinning manner, wherein the material is one selected from the group consisting of poly-L-lactic acid, poly-D-lactic acid, a polylactic acid-glycolic acid copolymer and polyglycolic acid. When the blood vessel construct prepared from the high polymer material is transplanted into subcutaneous tissue, an extracellular matrix space rich in new blood vessels can be rapidly formed under the skin of a subject and used for containing a donor-derived pancreatic island or pancreatic island cells to maintain the functions thereof for a long time.

Description

technical field [0001] The invention relates to the technical field of polymer materials, in particular to a neovascular construct for implanting into subcutaneous tissue of a subject and a preparation method thereof. Background technique [0002] Type I diabetes, formerly known as insulin-dependent diabetes, occurs in children or adolescents, and can also occur in various ages, especially menopause. It is a disease that is almost difficult to cure. The lack of islet cell function in the patient's body makes the patient prone to Ketoacidosis must be treated with insulin injections for life, otherwise it will be life-threatening. [0003] There are two goals of insulin therapy for type I diabetes. One is to ensure that patients have a good quality of life (that is, to avoid severe hypoglycemia as much as possible), and the other is to control metabolic levels to prevent diabetic complications. However, long-term insulin injections can lead to a series of complications, inclu...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61L29/06A61L29/14
CPCA61L29/06A61L29/14A61L29/148A61L2400/12C08L67/04
Inventor 牛玉清夏慧敏张锐忠付铭
Owner GUANGZHOU WOMEN AND CHILDRENS MEDICAL CENTER
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com