Application of mulberroside A and derivatives thereof in preparation of drug for protecting intestinal barrier

A technology of intestinal barrier and derivatives, applied in the field of medicine, can solve the problems of mulperiside A regulating intestinal flora disorder, neuroinflammation, etc., and achieve the effect of improving intestinal barrier damage

Inactive Publication Date: 2020-04-07
NANJING UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Studies have shown that mulberryside A has activities such as antitussive and asthmatic, tyrosinase inhibitory and anti-oxidant activities, but there is no report about the regulation of intestinal flora disorder and the inhibition of neuroinflammation by mulberryside A.

Method used

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  • Application of mulberroside A and derivatives thereof in preparation of drug for protecting intestinal barrier
  • Application of mulberroside A and derivatives thereof in preparation of drug for protecting intestinal barrier
  • Application of mulberroside A and derivatives thereof in preparation of drug for protecting intestinal barrier

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Example 1 Effect of Morbariside A on Neuroinflammation in the Hippocampus of High-Fructose Diet Mice

[0027] Experimental method: C57BL / 6N mice were randomly divided into normal group (n=15) and model group (n=60). The normal group was given normal diet, and the model group was given fructose-containing diet. Other feeding conditions were the same for both groups. After 4 weeks, the mice in the model group were randomly divided into 4 groups, namely the fructose model group (n=15), the 20mg / kg mulberryside A administration group (n=15), the 40mg / kg mulberryside A administration group (n=15) and 20 mg / kg resveratrol administration group (n=15). The model group continued to be fed with fructose feed, while the mulberryside A administration group and the resveratrol administration group were fed with fructose feed at the same time, the suspension of mulberryside A or resveratrol was made into normal saline, and then perfused. Stomach administration, gavage once a day. A...

Embodiment 2

[0030] Example 2 Effect of Morbariside A on Intestinal Barrier Damage in High-Fructose Diet Mice

[0031] See the experimental method above: C57BL / 6N mice were randomly divided into normal group (n=15) and model group (n=60). The normal group was given normal feed, and the model group was given fructose-containing feed. Other feeding conditions were the same for both groups. After 4 weeks, the mice in the model group were randomly divided into 4 groups, namely the fructose model group (n=15), the 20mg / kg mulberryside A administration group (n=15), the 40mg / kg mulberryside A administration group (n=15) and 20 mg / kg resveratrol administration group (n=15). The model group continued to be fed with fructose feed, while the mulberryside A administration group and the resveratrol administration group were fed with fructose feed at the same time, the suspensions made of mulberryside A or resveratrol with normal saline were fed. Stomach administration, gavage once a day. After 8 wee...

Embodiment 3

[0035] Example 3 Effects of Morin A on intestinal flora disorder of high fructose diet mice

[0036]See the experimental method above: C57BL / 6N mice were randomly divided into normal group (n=15) and model group (n=60). The normal group was given normal feed, and the model group was given fructose-containing feed. Other feeding conditions were the same for both groups. After 4 weeks, the mice in the model group were randomly divided into 4 groups, namely the fructose model group (n=15), the 20mg / kg mulberryside A administration group (n=15), the 40mg / kg mulberryside A administration group (n=15) and 20 mg / kg resveratrol administration group (n=15). The model group continued to be fed with fructose feed, while the mulberryside A administration group and the resveratrol administration group were fed with fructose feed at the same time, the suspension of mulberryside A or resveratrol was made into normal saline, and then perfused. Stomach administration, gavage once a day. Afte...

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Abstract

The invention relates to new application of mulberroside A and its derivative resveratrol in preparation of a drug for protecting the intestinal barrier. In the drug, the mulberroside A or the derivative thereof is an active ingredient. The influence of mulberroside A and its derivative on hippocampus neuroinflammation of high-fructose diet mice, the influence on intestinal barrier damage of high-fructose diet mice and the influence on intestinal flora disorder of high-fructose diet mice are studied through pharmacological experiments. It is found that the mulberroside A and its derivative canobviously inhibit activation of central microglial cells and inflammatory factor level of mice with high fructose diet. It is proved that the mulberroside A and its derivative have the effect of protecting the intestinal barrier, can be used for preparing a drug for preventing and / or treating central nervous inflammation and related neurodegenerative diseases caused by intestinal barrier damage,can remodel intestinal flora disorder caused by high fructose diet and are used for preparing a drug for adjusting intestinal flora disorder.

Description

technical field [0001] The invention relates to the application of mulperiside A and its derivatives in the preparation of medicines for protecting intestinal barrier, belonging to the technical field of medicine. Background technique [0002] With the improvement of people's living standard and the change of diet structure, the intake of dietary fructose, especially the intake of soft drinks containing high fructose corn syrup is increasing year by year. In the past decade, clinical research and experimental evidence have shown that high-fructose diets can easily cause intestinal flora disturbance and central nervous system inflammation. [0003] The intestinal tract is the part where organisms are in direct contact with the external environment, including various microorganisms and food. It has the functions of absorbing nutrients, electrolytes and water, and is very important for maintaining the homeostasis of the body and preventing the invasion of pathogens and harmful ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7034A61K31/05A61P1/00A61P25/00
CPCA61K31/7034A61K31/05A61P1/00A61P25/00
Inventor 孔令东李建梅孙洋郁蓉
Owner NANJING UNIV
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