Method for synthesizing 2-amino-4-chloro-5-nitrophenol in micro-channel reactor

Abstract

The invention discloses a method for synthesizing 2-amino-4-chloro-5-nitrophenol. The 2-amino-4-chloro-5-nitrophenol is prepared from 5-chloro-2-methylbenzoxazole through a series reaction using a micro-channel reactor and a batch reactor. The 2-amino-4-chloro-5-nitrophenol is synthesized by utilizing the micro-channel reactor, so that the adverse consequences that the process is difficult to control, dangers are caused by local overheating easily, side reactions are generated easily and the like in a conventional tank reactor are avoided, the intrinsic safety of the method is improved, and the method has the advantages of high production efficiency, high economical property, easiness in industrialization, and realization of continuous production. The micro-channel reactor has the characteristics of low price, convenience in transportation and cleaning, high heat and mass transfer efficiency, and easiness in industrial amplification. The synthesis method has the advantages of simple, cheap and accessible starting materials, simple technique, effectiveness in lowering of the production cost, and suitableness for industrial production.

Description

technical field [0001] The invention belongs to the technical field of synthesizing photosensitive materials and pharmaceutical intermediates, in particular to a method for synthesizing 2-amino-4-chloro-5-nitrophenol in a microchannel reactor. Background technique [0002] 2-Amino-4-chloro-5-nitrophenol is an important intermediate in the synthesis of photosensitive materials, dyes, medicines and pesticides. It has a wide range of uses and is a promising intermediate. There is no ideal industrial production method for -5 nitrophenol. At present, there are two main production methods for this intermediate, one is to synthesize 2-amino-4-chloro-5-nitrophenol through phosgene and 2-amino-4-chlorophenol; the other is traditional still-type closed-loop , nitrification, hydrolysis three-step method or two-step method. These two methods are backward in technology, long in process, low in yield and heavy in pollution. A document in the Photosensitive Society discloses a method fo...

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Problems solved by technology

[0002] 2-Amino-4-chloro-5-nitrophenol is an important intermediate in the synthesis of photosensitive materials, dyes, medicines and pesticides. It has a wide range of uses and is a promising intermediate. -5 Nitrophenol has never had an ideal industrial production method

These two methods are backward in technology, long in process, low in yield and heavy in pollution.

A document in the Photosensitive Society discloses a method for obtaining 3,4-dinitropyrazole by nitration reaction in a conventional reactor, which may cause production safety and environmental pollution, and is not conducive to continuous production

Moreover, due to the relationship between the size of the equipment, the traditional batch reactor often has the problem of low mass and heat transfer efficiency of the reactor, which is easy to cause uneven temperature and concentration, resulting in low yield, low production efficiency, and poor quality stability of intermittent operation products. , especially when dealing with "dangerous processes" such as nitrification and hydrogenation reduction, the safety hazards of the kettle reaction process are great, and due to factors such as reaction atom economy and process practicability, the alternatives to these "dangerous processes" are often costly and the route is longer

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