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Degradation-resisting, good-compatibility and absorbable medical suture line and preparation method thereof

A suture and compatibility technology, applied in medical science, coating, surgery, etc., can solve the problems of non-decomposability, non-physiological, inconvenient use, etc., to maintain appearance and mechanical physical properties, good biological Compatibility, easy operation effect

Inactive Publication Date: 2020-04-03
SHANDONG ZHUSHI PHARMA GRP CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In the second stage, the stage of artificial synthetic materials, alternative materials such as nylon and silk thread, which are synthetic polymer materials with high physical properties, have been developed and widely used. Among them, silk thread is the longest-used surgical suture, but these materials are in the human body. It is not decomposable and not physiologically compatible, so it should be removed by additional surgery after a predetermined time has elapsed after surgery, and it is inconvenient to use, so its use is limited

Method used

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  • Degradation-resisting, good-compatibility and absorbable medical suture line and preparation method thereof
  • Degradation-resisting, good-compatibility and absorbable medical suture line and preparation method thereof
  • Degradation-resisting, good-compatibility and absorbable medical suture line and preparation method thereof

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] Such as Figure 1-4 As shown, a kind of absorbable medical suture with good degradation resistance and compatibility is characterized in that: the suture wire material is a multi-strand braided thread, including a core yarn 1, a braided layer 2 and an antibacterial coating layer 3, the described The braided layer 2 is arranged on the outer side of the core yarn 1, and the antibacterial coating layer 3 is arranged on the outer side of the braided layer 2. The core yarn 1 includes a suture one, and the raw materials of the suture one include by weight: polyglycolide 50- 70 parts, 15-35 parts of carbon fiber, 5-15 parts of pure natural collagen; the braided layer 2 includes suture two, and the raw materials of the second suture include: 50-70 parts of polyglycolide, carbon fiber 15-35 parts, 5-15 parts of pure natural collagen, 2-4 parts of mannitol, 3-5 parts of vanillin.

Embodiment 2

[0044] A method for preparing absorbable medical sutures with good degradation resistance and compatibility, comprising the steps of:

[0045] S1: Production of core yarn 1: S11, weigh raw materials, chitosan and hyaluronic acid as required, dissolve chitosan in acetic acid solution and stir to obtain the first mixture; S12, add hyaluronic acid into the first mixture , stirring at a speed of 150-200rpm for 5-8min, defoaming to obtain a coating solution; S13, coating the suture with the coating solution and then drying to obtain a core yarn 1;

[0046]S2: Fabrication of braided layer 2: S21, weigh raw materials, chitosan and hyaluronic acid as required, dissolve chitosan in acetic acid solution and stir to obtain the first mixture; S22, add hyaluronic acid into the first mixture , after stirring at a speed of 150-200rpm for 5-8min, defoaming to obtain a coating solution; S23, drying the suture thread 2 after coating it with the coating solution, to obtain a single-strand rope o...

Embodiment 3

[0051] The raw materials of the suture one include by weight: 65 parts of polyglycolide, 26 parts of carbon fiber, and 14 parts of pure natural collagen;

[0052] The raw materials of suture thread 2 include, by weight, 60 parts of polyglycolide, 30 parts of carbon fiber, 14 parts of pure natural collagen, 3 parts of mannitol, and 4 parts of vanillin.

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Abstract

The invention relates to a degradation-resisting, good-compatibility and absorbable medical suture line. The suture line is composed of a plurality of threads of braided lines, and comprises a core yarn, a braided layer and an antibacterial coating layer, wherein the braided layer is arranged at the outer side of the core yarn; the antibacterial coating layer is arranged at the outer side of the braided layer; the core yarn comprises a suture line I; the suture line I is prepared from the following raw materials in parts by weight: polyglycolide, carbon fibers and pure natural collagen; the braided layer comprises a suture line II; and the suture line II is prepared from the following raw materials in parts by weight: polyglycolide, carbon fibers, pure natural collagen, mannitol and vanillin. The invention further provides a preparation method of the degradation-resisting, good-compatibility and absorbable medical suture line. The degradation-resisting, good-compatibility and absorbable medical suture line provided by the invention has the following beneficial effects that the suture line is applicable to industrial production, has an extremely good application prospect, is great in tensile strength and is not easy to break; and the suture line has good biocompatibility and degradability, and can be absorbed after being used for suturing so that stitches do not need to be takenout.

Description

technical field [0001] The invention relates to an absorbable medical suture with good degradation resistance and compatibility and a preparation method thereof, belonging to the technical field of medical suture preparation. Background technique [0002] Medical suture refers to the special medical thread used for ligation hemostasis, suture hemostasis and tissue suture in surgical operation, which is divided into absorbable suture and non-absorbable suture. The development of sutures is divided into two stages: the first stage, the natural material stage, uses tendon, flax, hair leather, cotton thread, leather, etc. as sutures. In the second stage, the stage of artificial synthetic materials, alternative materials such as nylon and silk thread, which are synthetic polymer materials with high physical properties, have been developed and widely used. Among them, silk thread is the longest-used surgical suture, but these materials are in the human body. Since it is not decom...

Claims

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Application Information

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IPC IPC(8): A61L17/06A61L17/10A61L17/14A61B17/06
CPCA61B17/06166A61B2017/00004A61B2017/0618A61L17/06A61L17/10A61L17/105A61L17/145A61L2300/232A61L2300/404
Inventor 吴德成朱坤福薛飞
Owner SHANDONG ZHUSHI PHARMA GRP CO LTD
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