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Potassium glycyrrhetate and its preparing process and use

A production process, a technology of potassium hypoacid, applied in the directions of steroids, metabolic diseases, organic chemistry, etc., can solve problems such as less adverse reactions, and achieve the effects of convenient use, strong process practicability, and obvious hypolipidemic effect.

Inactive Publication Date: 2003-05-21
NINGXIA UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In 1937, W. Voss and P. Kiiein first synthesized glycyrrhetinic acid derivatives—monopotassium glycyrrhetinate and monoammonium, both of which showed strong anti-inflammatory activity and less adverse reactions, but no licorice was found. A report on the production process and application of potassium hypochlorite

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] The potassium glycyrrhetinate, molecular formula C 30 h 45 o 4 K, the molecular weight is 508, and the structural formula is:

[0018] The production process of potassium glycyrrhetinate is specifically: glycyrrhetinic acid is hydrolyzed to generate glycyrrhetinic acid, and glycyrrhetinic acid is reacted with potassium hydroxide to generate potassium glycyrrhetinate. The reaction equation is:

[0019]

[0020] The concrete process example according to above reaction is:

[0021] Take 100g of glycyrrhizic acid crude acid (containing 65% acid), put it into the reactor, add 720ml of water, 80ml of concentrated hydrochloric acid, heat the reaction in an oil bath, raise the temperature to 120°C, react for 6 hours, remove and cool to room temperature, filter and wash To no chlorine, take out the precipitate and dry it, grind the dry product and put it into the percolator, add 400ml of chloroform, heat it for percolation until the outflowing chloroform is col...

Embodiment 2

[0023] Take 100g of glycyrrhizic acid crude acid (containing 75% acid), put it into the reactor, add 720ml of water, 80ml of concentrated hydrochloric acid, heat the reaction in an oil bath, raise the temperature to 100°C, react for 6 hours, take it down and cool to room temperature, filter and wash To no chlorine, take out the precipitate and dry it, grind the dry product and put it into the percolator, add 400ml of chloroform, heat it for percolation until the outflowing chloroform is colorless, distill and recover the chloroform, evaporate to dryness and then dry it, add ethanol (95%) 300ml, heat to dissolve, decolorize with 50g of activated carbon, filter, and wash with ethanol. Heat the decolorized ethanol solution to a slight boil, add an equal volume of boiling distilled water, let it stand, cool, filter, wash, take out the precipitate and dry it to obtain 16.7g, add 16.7g of the precipitate to 200ml of ethanol, dissolve and add 2g of hydroxide Potassium ethanol solutio...

Embodiment 3

[0025] Take 100g of glycyrrhizic acid crude acid (containing 85% acid), put it into the reactor, add 720ml of water, 80ml of concentrated hydrochloric acid, heat the reaction in an oil bath, raise the temperature to 110°C, react for 6 hours, take it down and cool to room temperature, filter and wash To no chlorine, take out the precipitate and dry it, grind the dry product and put it into the percolator, add 400ml of chloroform, heat it for percolation until the outflowing chloroform is colorless, distill and recover the chloroform, evaporate to dryness and then dry it, add ethanol (95%) 300ml, heat to dissolve, decolorize with 50g of activated carbon, filter, and wash with ethanol. Heat the decolorized ethanol solution to a slight boil, add an equal volume of boiling distilled water, let it stand, cool, filter, wash, take out the precipitate and dry it to obtain 16.7g, add 16.7g of the precipitate to 200ml of ethanol, dissolve and add 2g of hydroxide Potassium ethanol solutio...

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PUM

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Abstract

A potassium glycyrrhetate (C30H45O4K) is prepared from glycyrrhizic acid through hydrolysis to generate glycyrrhetic acid, and reaction with potassium hydroxide. It is a white powder with medical function of reducing blood fat and treating inflammation, hypersensitivity, virus, cough, asthma, etc.

Description

technical field [0001] The invention relates to potassium glycyrrhetinate and its production process and application. Background technique [0002] Glycyrrhetinic acid has anti-inflammatory, anti-ulcer, anti-allergic, anti-viral, hypolipidemic, antitussive, anti-asthma effects. In 1937, W. Voss and P. Kiiein first synthesized glycyrrhetinic acid derivatives—monopotassium glycyrrhetinate and monoammonium, both of which showed strong anti-inflammatory activity and less adverse reactions, but no licorice was found. Report on the production process and application of potassium hypochlorite. Contents of the invention [0003] The object of the present invention is to expand glycyrrhetinic acid derivatives, provide a practical potassium glycyrrhetinate suitable for industrial production and its production process and application. [0004] To achieve the above object, the present invention adopts the following technical solutions: [0005] A kind of potassium glycyrrhetinate, ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61P3/06C07J63/00
Inventor 刘钢刘祎春刘成敏
Owner NINGXIA UNIVERSITY
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