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Gradient composite bar material and manufacturing method thereof

A manufacturing method and composite rod technology, applied in the field of medical devices, can solve the problems of causing chronic inflammation, rejection reaction, and difficulty in recovery, and achieve the effects of slowing down the degradation speed, slowing down the debilitating speed, and facilitating bone conduction.

Active Publication Date: 2020-03-24
HANGZHOU DIANZI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the intramedullary nails currently used clinically are mainly made of stainless steel and titanium alloys. The mechanical strength of the intramedullary nails made of these alloys does not match that of human bones, which will produce a stress shielding effect, making the healing effect of fractures poor or even failure.
At the same time, this type of intramedullary nail will slowly release toxic ions or particles after being implanted in the body, causing chronic inflammation, making it difficult to heal and having poor biological activity.
In addition, this type of intramedullary nail does not degrade in the body and requires a second operation to remove it, which causes complications and increases the economic burden and pain of the patient
[0003] Absorbable intramedullary nails can solve some of the above problems, but currently clinical absorbable devices are basically made of polymer materials, such as polylactic acid, polyvinyl alcohol, chitosan, etc. Acidic substances can also cause rejection

Method used

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  • Gradient composite bar material and manufacturing method thereof
  • Gradient composite bar material and manufacturing method thereof
  • Gradient composite bar material and manufacturing method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0053] 1) Evenly mix 55% calcium magnesium silicate powder with 2.1% polyvinyl alcohol, 0.5% polyacrylic acid, 0.5% Surfynol and 41.9% deionized water to obtain bioink A, and then Bioink B was obtained by uniformly mixing 50% hydroxyapatite with 2.2% polyvinyl alcohol, 0.5% polyacrylic acid, 0.5% Surfynol and 46.8% deionized water.

[0054] 2) According to the shrinkage rate of bio-inks A and B, the outer contour A of the quartz tube with an inner diameter of 6.8mm and a wall thickness of 1.6mm is customized, a shell with an inner diameter of 6.1mm and a wall thickness of 1mm, and a matching center seat.

[0055] 3) Stand up the outer contour A, and then slowly inject the bio-ink A prepared in step 1) into the outer contour A from bottom to top. After filling, put the bio-ink A and the outer contour A together at minus 70 o C for 3 hours in the freezer.

[0056] 4) Freeze-dry the above-mentioned frozen samples with a freeze dryer to separate the rough rod of bio-ink A and the...

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Abstract

The invention discloses a gradient composite bar material and a manufacturing method thereof. The bar material is formed by two times of freeze drying shaping and two times of high temperature sintering; the bar material is perfectly straight and is composed of two parts, namely an inner layer and an outer layer, the outer layer uniformly wraps the inner layer, the degradation speed of the outer layer is lower than that of the inner layer, and the mechanical strength of the inner layer is higher than that of the outer layer. The bar material has high mechanical strength and good biological activity, the bar material can be continuously absorbed in vivo, a phosphate layer is generated in the absorption and degradation process, and bone conduction is facilitated. Due to the gradient degradation design of the bar material, time and mechanical support guarantee is provided for fracture healing, and fracture healing can be better promoted.

Description

technical field [0001] The invention relates to a device in the technical field of medical devices and a manufacturing method thereof, in particular to a gradient composite rod and a manufacturing method thereof. Background technique [0002] In real life, people often fracture, and implanting internal fixation implants, such as intramedullary nails, is the most common treatment. However, the intramedullary nails currently used clinically are mainly made of stainless steel and titanium alloys. The mechanical strength of the intramedullary nails made of these alloys does not match that of human bones, which will produce a stress shielding effect, making the healing effect of fractures poor or even failure. . At the same time, this type of intramedullary nail will slowly release toxic ions or particles after being implanted in the body, causing chronic inflammation, resulting in difficult recovery and poor biological activity. In addition, this type of intramedullary nail do...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C04B35/20C04B35/447C04B35/622A61B17/68C04B41/87
CPCC04B35/20C04B35/447C04B35/622A61B17/68C04B41/009C04B41/5048C04B41/87C04B2235/6022C04B2235/606C04B2235/656C04B2235/6562C04B2235/6567C04B2235/94C04B41/4535C04B41/0072
Inventor 邵惠锋贺永傅建中龚友平刘海强陈慧鹏李文欣陈国金
Owner HANGZHOU DIANZI UNIV
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