Compound antiviral preparation of black tiger palm extract and preparation method and use thereof

An extract and anti-virus technology, which is applied in the direction of anti-viral agents, medical preparations containing active ingredients, and pharmaceutical formulas, can solve problems such as hindering the development of natural medicines, insignificant, and difficult to obtain effects of natural medicines, and achieve the maintenance of natural medicines. Pharmacological effects, low side effects, no effect of drug resistance

Active Publication Date: 2021-08-10
GUANGDONG INST OF MICROBIOLOGY GUANGDONG DETECTION CENT OF MICROBIOLOGY +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the development of natural medicines has been hindered by defects such as the difficulty in obtaining the ingredients of natural medicines and the insignificant effects.

Method used

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  • Compound antiviral preparation of black tiger palm extract and preparation method and use thereof
  • Compound antiviral preparation of black tiger palm extract and preparation method and use thereof
  • Compound antiviral preparation of black tiger palm extract and preparation method and use thereof

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0026] In a second aspect, a method for preparing an antiviral preparation is provided, comprising:

[0027] (1), dehydrating and pulverizing the sporocarp of A. nigriscens at a low temperature below 20°C;

[0028] (2), adding 2-10 times the volume for leaching 1-3 times, each time for 1-4 hours, and using ultrasonic vibration to dissolve the quick-active substance, merging the filtrate after suction filtration, concentrating and drying the filtrate to obtain an alcohol extract;

[0029] (3), adding 5-30 times water to the filter residue after alcohol extraction and ultrasonically extracting 1-4 times, each time for 1-4 hours, after filtering, the filtrate was combined, and the filtrate was concentrated and freeze-dried to obtain the water extract;

[0030] (4) The water extract powder and the alcohol extract are mixed in a weight ratio of 30%-90%:10%-70% to obtain an antiviral preparation.

[0031] Preferably, the alcohol is ethanol, such as 90% ethanol.

[0032] Preferably...

Embodiment 1

[0045] Dehydrate and pulverize the fruiting body of the black tiger palm at a low temperature below 20°C, add 8 times the volume of 90% ethanol to extract 3 times, each time for 3 hours, and use ultrasonic vibration to dissolve the active substance, and combine the filtrate after suction filtration , the filtrate was concentrated and freeze-dried into powder to obtain alcohol extract. The filter residue after alcohol extraction was added to 10 times of 20°C water and ultrasonically extracted for 3 times, each time for 2 hours, after filtering, the filtrate was combined, and the filtrate was concentrated and freeze-dried into powder to obtain the water extract. Finally, the powder of the water extract and the powder of the alcohol extract are mixed to obtain a composite antiviral preparation, wherein the weight percentage of the water extract is 85%, and the weight percentage of the alcohol extract is 15%.

Embodiment 2

[0047] Dehydrate and pulverize the fruiting bodies of the black tiger palm at a low temperature below 20°C, add 6 times the volume of 90% ethanol to extract 3 times, each time for 3 hours, and use ultrasonic vibration to dissolve the active substances, and combine the filtrates after suction filtration , the filtrate was concentrated and freeze-dried into powder to obtain alcohol extract. The filter residue after alcohol extraction was added to 15 times of 20°C water and ultrasonically extracted for 3 times, each time for 2 hours, after filtration, the filtrate was combined, and the filtrate was concentrated and freeze-dried into powder to obtain the water extract. Finally, the powder of the water extract and the powder of the alcohol extract are mixed to obtain a compound antiviral preparation, wherein the weight ratio of the water extract is 80%, and the weight ratio of the alcohol extract is 20%.

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Abstract

The invention relates to the extraction of active ingredients of edible fungi and preparation of preparations, in particular to a composite antiviral preparation of black tiger palm extract and its preparation method and application. A composite antiviral preparation, in terms of weight percentage, the preparation comprises 10%-70% alcohol extract and 30%-90% water extract, and the alcohol extract is the alcohol extract of the fruiting body of the black tiger palm fungus, The water extract is the water extract of the filter residue after alcohol extraction of the fruiting body of Helicobacter spp. Through experimental verification, it is found that the preparation of the invention has low side effects, has a good inhibitory effect on herpes simplex virus and enterovirus, and has no drug resistance phenomenon.

Description

technical field [0001] The invention relates to the extraction of effective components of edible fungi and the preparation of antiviral preparations, in particular to a composite antiviral preparation of black tiger palm extract and its preparation method and application. Background technique [0002] Viruses are the main culprits of infectious diseases, which are extremely harmful and have a wide impact. Today, with the rapid development of science, it is still one of the biggest puzzles faced by developed countries and many developing countries. In recent years, due to the wanton spread of viruses, antiviral drugs have developed rapidly and have become an important type of anti-infective drugs. However, drugs that are highly selective, act on cell virus metabolism, and have no obvious damage to the host are still under research. the key of. Since the 1990s, under the impetus of combinatorial chemistry and high-throughput screening technology, in the study of virology and...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/07A61P31/14A61P31/22
CPCA61K36/07A61K2236/15A61K2236/331A61K2236/39A61K2236/51A61P31/14A61P31/22
Inventor 潘鸿辉蔡超王弋雷苏炜陈少丹谢意珍
Owner GUANGDONG INST OF MICROBIOLOGY GUANGDONG DETECTION CENT OF MICROBIOLOGY
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