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Preparation method for extracting glycyrrhizic acid by coupling liquid nitrogen and high-pressure homogenization

A technology of high-pressure homogenization method and high-pressure homogenizer, which is applied to the preparation of sugar derivatives, chemical instruments and methods, steroids, etc., can solve the problems of backward in-depth research on refined processing and comprehensive utilization, insufficient utilization of licorice resources, Affecting the development of licorice industry and other issues, to achieve the effect of ensuring the product's fineness, color and fragrance are completely preserved, and the total extraction time is short

Inactive Publication Date: 2020-03-10
NANJING ZELANG AGRI DEV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Although my country is a big country in the production and export of licorice, the in-depth research on the synthesis, mechanism of action, refined processing and comprehensive utilization of glycyrrhizic acid, the main active ingredient of licorice, still lags behind Japan and other countries.
At present, although the extraction technology of plant extracts in my country has continuously broken through, and microwave-assisted methods, ultrasonic-assisted methods, supercritical extraction methods, enzymatic hydrolysis methods, etc. have appeared one after another, most of the raw materials are processed by traditional mechanical grinding methods. Glycyrrhizic acid extracted by traditional wall-breaking methods has a low price in the international market, and the extraction efficiency is also low. The utilization of licorice resources is not sufficient, which affects the development of my country's licorice industry.
The active ingredients of plant medicine usually exist in the vacuole in the cell protoplasm, and the complete cell wall and cell membrane will form resistance to the release of the active ingredient, and the resistance will increase with the increase of the number of cells in the cell mass, so only conventional machinery When the method is used for wall-breaking treatment, it will inevitably result in complicated operation steps, long time use, incomplete extraction and low extraction efficiency, and high temperature will easily cause inactivation of some active ingredients.

Method used

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  • Preparation method for extracting glycyrrhizic acid by coupling liquid nitrogen and high-pressure homogenization
  • Preparation method for extracting glycyrrhizic acid by coupling liquid nitrogen and high-pressure homogenization

Examples

Experimental program
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Effect test

Embodiment 1

[0021] Pre-treatment of raw materials: licorice raw materials must be free from diseases and insect pests, and the residual amount of pesticide components does not exceed the national standard. In order to avoid the average time in the high-pressure homogenizer being too long, the raw materials must be preliminarily crushed and passed through a 100-mesh sieve.

[0022] Micronization of raw materials: Mix the crushed and sieved dry powder with liquid nitrogen at a material-to-liquid ratio of 1:10, and then quickly enter the high-pressure homogenizer for micronization treatment. The pressure of the homogenizer is 100Mpa, and the homogenization time is 5min. , The average power is 50KW.

[0023] Active ingredient extraction: Take the above-mentioned licorice powder of a certain quality and put it into an enamel reaction kettle, add water at a material-to-liquid ratio of 1:6, slowly heat to 100°C, stir and extract for 2 hours, and then filter. Add water to the filter residue and e...

Embodiment 2

[0029] Pre-treatment of raw materials: licorice raw materials must be free from diseases and insect pests, and the residual amount of pesticide components does not exceed the national standard. In order to avoid the average time in the high-pressure homogenizer being too long, the raw materials must be preliminarily crushed and passed through a 100-mesh sieve.

[0030] Micronization of raw materials: The crushed and sieved dry powder is mixed with liquid nitrogen at a material-to-liquid ratio of 1:6, and then quickly enters a high-pressure homogenizer for micronization treatment. The pressure of the homogenizer is 100Mpa, and the homogenization time is 6 minutes. , The average power is 50KW.

[0031] Active ingredient extraction: Take the above-mentioned licorice powder of a certain quality and put it into an enamel reaction kettle, add water at a material-to-liquid ratio of 1:6, slowly heat to 100°C, stir and extract for 2 hours, and then filter. Add water to the filter resid...

Embodiment 3

[0037] Pre-treatment of raw materials: licorice raw materials must be free from diseases and insect pests, and the residual amount of pesticide components does not exceed the national standard. In order to avoid the average time in the high-pressure homogenizer being too long, the raw materials must be preliminarily crushed and passed through a 100-mesh sieve.

[0038] Micronization of raw materials: Mix the crushed and sieved dry powder with liquid nitrogen at a material-to-liquid ratio of 1:7, and then quickly enter the high-pressure homogenizer for micronization treatment. The pressure of the homogenizer is 100Mpa, and the homogenization time is 7 minutes. , The average power is 50KW.

[0039] Active ingredient extraction: Take the above-mentioned licorice powder of a certain quality and put it into an enamel reaction kettle, add water at a material-to-liquid ratio of 1:6, slowly heat to 100°C, stir and extract for 2 hours, and then filter. Add water to the filter residue a...

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Abstract

The invention discloses a preparation method for extracting glycyrrhizic acid by coupling liquid nitrogen and high-pressure homogenization, and belongs to the technical field of natural plant effective component extraction. The method mainly comprises the following steps: mixing a liquorice raw material by utilizing the specific freezing property of liquid nitrogen, preparing superfine powder by combining a high-pressure homogenizer, and further performing leaching, concentration and spray drying to obtain glycyrrhizic acid. According to the invention, the method has the following advantages that the crushing process is operated at an ultralow temperature, free water in raw material cells is rapidly solidified, metabolism is inhibited, and plant materials are in a physiological pause state, so that the extract is protected from being degraded and oxidized to the greatest extent; the high-pressure homogenizer generates strong shearing, impacting and cavitation effects under a high pressure, so that the product is micronized. According to the invention, the method has advantages of good crushing effect, high extraction rate of effective components and low energy consumption, and caneliminate the adsorption agglomeration phenomenon of nano-powder due to electrostatic interaction; and the obtained glycyrrhizic acid is widely applied to the medicine or functional food industry.

Description

technical field [0001] The invention belongs to the technical field of natural plant active ingredient extracts, and relates to a preparation method for extracting glycyrrhizic acid by a liquid nitrogen coupled high-pressure homogenization method. Background technique [0002] The traditional Chinese medicine licorice is also known as sweet grass and beautiful grass. Leguminous plants are mostly distributed in Northwest my country, North China, and Northeast China. They have excellent characteristics such as cold resistance, heat resistance, drought tolerance, and salt-alkali resistance. They are one of the important plant resources in arid and semi-arid areas. It is a widely used Chinese herbal medicine. It not only has the effects of invigorating the spleen and replenishing qi, clearing heat and detoxifying, eliminating phlegm and relieving cough, and reconciling various medicines, but also has important functions such as antibacterial, antiviral, anti-inflammatory, anti-...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07J63/00C07H15/256C07H1/08
CPCC07H1/08C07H15/256C07J63/008
Inventor 于霞刘东锋袁凤霞
Owner NANJING ZELANG AGRI DEV
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