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Preparation method and application of anti-allergy compound

A compound and extract technology is applied in skin care preparations, medical preparations containing active ingredients, pharmaceutical formulations, etc. The effect of analgesic effect

Pending Publication Date: 2020-03-06
江苏巴帝恩生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] In order to overcome the problem that the compound liquid in the prior art has poor binding effect and the effect cannot be fully exerted, a method for preparing an anti-allergic compound is proposed, which is characterized in that: fermenting the yeast to obtain a fermented liquid, adding Purslane flower / leaf / stem extract, golden chamomile extract, centella asiatica flower / leaf / stem extract, citrus fruit extract and grape skin extract, heated to 40-50°C and stirred to dissolve; anti-allergic compound solution The following components are compounded: including 8-15% purslane flower / leaf / stem extract, 3-8% golden chamomile extract, 3-8% centella asiatica flower / leaf / stem extract , 0.5-1% citrus fruit extract, 1-5% grape skin extract and the remaining supernatant of the fermentation broth

Method used

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  • Preparation method and application of anti-allergy compound
  • Preparation method and application of anti-allergy compound
  • Preparation method and application of anti-allergy compound

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] 1. Inoculate Saccharomyces cerevisiae cultured on a shaker in advance into yeast medium (YPD medium) for fermentation. The fermentation conditions are: pH range 3.0-7.0, fermentation temperature 25°C, shaker speed 80rpm, fermentation time 2d.

[0034] 2. Use a TDL-80-2B low-speed centrifuge to centrifuge the fermented broth at a speed of 7000 rpm / min, collect and separate the supernatant, and filter it through a 0.22 μm microporous membrane.

[0035]3. The solvent used for the extraction of purslane is 60% ethanol, the ratio of solid to liquid is 1:15, the ultrasonic-assisted extraction time at room temperature is 30 minutes, and then heated for 2 hours, the extraction temperature is 70°C, the ethanol is concentrated at 65°C, 1um filter paper plate Filtration, macroporous resin for separation and purification, the injection speed, eluent concentration and elution speed are respectively 0.5ml / min, 60% ethanol, 1ml / min. Add butanediol to make a 1:1 solution of liquid to b...

Embodiment 2

[0042] 1. Inoculate Saccharomyces cerevisiae cultured on a shaker in advance into yeast medium (YPD medium) for fermentation. The fermentation conditions are: pH range 3.0-7.0, fermentation temperature 30°C, shaker speed 150rpm, fermentation time 4d.

[0043] 2. Use a TDL-80-2B low-speed centrifuge to centrifuge the fermented broth at a speed of 7000 rpm / min, collect and separate the supernatant, and filter it through a 0.22 μm microporous membrane.

[0044] 3. The solvent used for the extraction of purslane is 65% ethanol, the ratio of solid to liquid is 1:20, the ultrasonic-assisted extraction time is 40min, and then heated for 2h, the extraction temperature is 75°C, the ethanol is concentrated at 70°C, and filtered with a 1um filter paper board , macroporous resin for separation and purification, the injection speed, eluent concentration and elution speed are respectively 1ml / min, 60% ethanol, 1.8ml / min. Add butanediol to make a solution with a ratio of liquid to butanediol...

Embodiment 3

[0051] 1. Inoculate Saccharomyces cerevisiae cultured on a shaker in advance into yeast medium (YPD medium) for fermentation. The fermentation conditions are: pH range 3.0-7.0, fermentation temperature 32°C, shaker speed 180rpm, fermentation time 3d.

[0052] 2. Use a TDL-80-2B low-speed centrifuge to centrifuge the fermented broth at a speed of 7000 rpm / min, collect and separate the supernatant, and filter it through a 0.22 μm microporous membrane.

[0053] 3. The solvent used for the extraction of purslane is 70% ethanol, the ratio of solid to liquid is 1:25, the ultrasonic-assisted extraction time is 60min, and then heated for 4h, the extraction temperature is 85°C, the ethanol is concentrated at 75°C, and filtered with a 1um filter paper board , macroporous resin for separation and purification, the injection speed, eluent concentration and elution speed were 1.8 ml / min, 70% ethanol, 3.5ml / min. Add butanediol to make a solution with a ratio of liquid to butanediol of 1:1. ...

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Abstract

The invention provides a preparation method and application of an anti-allergy compound, and belongs to the field of cosmetics. The preparation method comprises the following steps: fermenting saccharomycetes to obtain a fermentation broth, adding purslane flower / leaf / stem extracts, golden chamomile extracts, centella flower / leaf / stem extracts, Chinese holly fruit extracts and grape skin extracts,and carrying out heating to 40-50 DEG C and carrying out stirring and dissolving, wherein the anti-allergy compound liquid is compounded from the following components: 8-15% of purslane flower / leaf / stem extracts, 3-8% of golden chamomile extracts, 3-8% of centella flower / leaf / stem extracts, 0.5-1% of Chinese wolfberry fruit extracts, 1-5% of grape skin extracts and the balance of supernatant of the fermentation broth. The problems that the combination effect of the compound liquid is poor and the effect cannot be completely exerted can be solved, and the anti-allergy compound has better anti-sensitivity, anti-oxidation and sedation effects.

Description

technical field [0001] The invention relates to the technical field of cosmetics, in particular to an anti-allergic compound, its preparation method and application. Background technique [0002] In recent years, with changes in dietary structure, air pollution, and increased pressure in life and work, the number of allergic patients has increased dramatically. According to the 2017 and 2018 statistics of the five dermatological diagnosis institutions identified by the Ministry of Health of my country, contact dermatitis is the most common of the six major cosmetic dermatological diseases, and the two-year incidence rate accounts for 82.6% and 93.3%. There are a lot of chemical additives in most cosmetics on the market, which can easily cause skin sensitivity and even inflammation. Sensitive skin is very prone to allergies when using ordinary cosmetics. Cosmetics with anti-allergic and anti-irritant effects are increasingly valued by people, and substances with anti-allergi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/9728A61K8/9789A61Q19/00A61Q19/02
CPCA61K8/9728A61K8/9789A61Q19/005A61Q19/02A61K2800/5922A61K2800/85
Inventor 陈秀玉卢勇丁冲冲詹柱郑海兵刘晓磊钱峰
Owner 江苏巴帝恩生物科技有限公司
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