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Production method and production device for chemical product by continuous fermentation

A technology for manufacturing devices and manufacturing methods, which is applied in the field of chemical manufacturing and manufacturing devices based on continuous fermentation, which can solve the problems of reduced filtration capacity, inability to send culture liquid to membrane modules, and blockage, and achieve the effect of suppressing blockage

Active Publication Date: 2020-02-21
TORAY IND INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] On the other hand, in the continuous fermentation method, during the filtration operation, the pores of the flow path and the membrane are clogged by the solid content in the culture solution, so that the filtration ability is reduced, or the culture solution cannot be sent to Membrane module

Method used

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  • Production method and production device for chemical product by continuous fermentation
  • Production method and production device for chemical product by continuous fermentation
  • Production method and production device for chemical product by continuous fermentation

Examples

Experimental program
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Embodiment

[0196] Hereinafter, an Example is shown and this invention is demonstrated more concretely. However, the present invention is not limited by these Examples. The general configuration of the continuous fermentation apparatus used in the following examples, except for the configuration related to the addition of the solid content removal mechanism and the solid content discharged from the removal mechanism, is as follows: figure 1 shown. In addition, in the following examples, lactic acid or methane was produced as a chemical by continuous fermentation.

[0197] [Measurement method of A.D-lactic acid concentration]

[0198] The concentration of D-lactic acid contained in the culture solution was measured by the following method. Confirmation was carried out by taking 100 µL of the culture solution containing D-lactic acid and measuring the amount of lactic acid by the HPLC method under the conditions shown below.

[0199] Column: Shim-Pack SPR-H (manufactured by Shimadzu Cor...

reference example 1

[0258] Using a membrane separation module with an opening of 1 mm in the removal mechanism and a major diameter of the opening of 10 mm, lactic acid fermentation was carried out under the condition that the discharge from the removal mechanism was not refluxed and not added to the fermenter. Although stable filtration was achieved at 250 hours and under the condition of a differential pressure between the membranes of 30 kPa or less, the average lactic acid accumulation concentration was 3.7 g / L from 100 h to 150 h after the start of filtration.

reference example 2

[0260] Lactic acid fermentation was performed using a membrane separation module having an opening of 0.1 mm in the removal mechanism and a major diameter of the opening of 5 mm. The results are shown in Table 1. Filtration was stable for 250 hours and the differential pressure between the membranes was 30kPa or less, and the average lactic acid accumulation concentration was 4.2g / L from 100h to 150h after the start of filtration. In addition, compared with Reference Example 1, the lactic acid accumulation concentration can be maintained higher.

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Abstract

Provided is a chemical product production method wherewith filterability and productivity with respect to a target substance can be both achieved. The present invention is provided with a mechanism for removing solid contents in a pipe connecting a fermentation tank and a filter separation module, and adds the solid contents removed by the removal mechanism to a culture liquid.

Description

technical field [0001] The present invention relates to a production method and production apparatus of chemicals based on continuous fermentation. Background technique [0002] The continuous fermentation method is one of the production methods of substances involving the cultivation of cells (hereinafter, "microorganisms" are included in "cells"). [0003] In the continuous fermentation method, the liquid volume in the fermenter can always be kept constant by supplying fresh culture medium to the fermenter and discharging the same amount of culture liquid out of the tank. In the continuous fermentation method, in order to maintain the concentration of microorganisms in the fermenter, it is proposed to separate the microorganisms from the discharged culture solution with a separation membrane, and use the filtrate from which the microorganisms have been removed for the purification of the target substance. The separated microorganisms are returned to the culture solution (...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12P1/00B01D61/14C12M1/12C12P7/56
CPCB01D61/14C12M1/12C12P1/00C12P7/56C12M21/12C12M29/16C12M29/18C12M21/04C12M47/02C12M47/10C12M29/04C12P5/023Y02E50/30B01D61/18
Inventor 志村芙美金森智子高木亮太
Owner TORAY IND INC
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