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Jujube processed product capable of improving colon cancer and/or rectal cancer immunotherapy effects and using method thereof

A technology of immunotherapy and processed products, applied in the field of medicinal efficacy of natural products to achieve the effect of tumor reduction

Inactive Publication Date: 2020-02-18
新疆天辰智慧信息科技有限公司 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The efficacy of jujube in enhancing immunity and anti-tumor suggests that supplementation of processed red jujube products with tumor immunotherapy may improve the therapeutic effect; 1 / PD-L1 inhibitors are used in combination to improve the response rate and anti-tumor effect of PD-1 / PD-L1 inhibitors

Method used

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  • Jujube processed product capable of improving colon cancer and/or rectal cancer immunotherapy effects and using method thereof
  • Jujube processed product capable of improving colon cancer and/or rectal cancer immunotherapy effects and using method thereof
  • Jujube processed product capable of improving colon cancer and/or rectal cancer immunotherapy effects and using method thereof

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0036] The preparation technology of two kinds of jujube powders is as follows:

[0037] Jujube powder A: Remove the pits from the red dates, cut them into thin slices with a thickness not exceeding 2mm, put them in a vacuum drying oven, and dry them for 72 hours at a temperature of 40°C and a vacuum degree of 0.07Mpa until the water content is 5% (wet basis) , and then use an experimental traditional Chinese medicine pulverizer to pre-crunch to 50 meshes. During the pre-crushing process, multiple crushing and intermediate cooling methods are used to ensure that the temperature of the jujube slices during the crushing process does not exceed 40°C; and then the pre-crushed materials After being cryogenically cooled with liquid nitrogen, it was further pulverized to below 270 mesh (sieving particle size is 53 μm) by using an ultrafine pulverizer.

[0038] Red date powder B: remove the core of red dates, cut into thin slices with a thickness of no more than 2mm, then put them in ...

Embodiment 1

[0043] This example uses jujube powder A to improve the therapeutic effect of PD-1 / PD-L1 antibody.

[0044] The tumor model animal used was the MC38 colon cancer mouse model, and each mouse was given 200 mg of α-PD-L1 (purchased from BioXCell, USA) for treatment (peritoneal injection) on the 7th and 10th days after tumor inoculation. Immediately after the first injection, jujube powder A was administered to tumor-bearing mice at a dosage of 0.8 g / kg per day for 30 days; PD-1 treated mice were used as controls (6 mice in each group). After 30 days of treatment, the tumor volume growth of mice in each group is shown in the attached figure 1 As shown, the tumor volume of the jujube powder A adjuvant treatment group was reduced by 42% compared with the control group using only α-PD-L1; compared with the blank control group, the tumor volume was reduced by 70%. At the same time (if attached figure 2 As shown), the jujube powder A adjuvant treatment group was compared with the c...

Embodiment 2

[0046] This example uses jujube powder B to improve the therapeutic effect of PD-1 / PD-L1 antibody.

[0047] The tumor model animal used was the MC38 colon cancer mouse model. From the first day after tumor inoculation, jujube powder was administered to tumor-bearing mice at a dosage of 0.6 g / kg per day for 36 days; Each mouse was given 200mgα-PD-L1 treatment (peritoneal injection) on the 7th and 10th day. The mice that did not receive any treatment were used as the blank control, and the mice that received only α-PD-1 treatment were used as the control (6 mice in each group). After 30 days of treatment, the tumor volume growth of mice in each group is shown in the attached figure 1 As shown, the tumor volume of the jujube powder B adjuvant treatment group was reduced by 37% compared with the control group using only α-PD-L1; compared with the blank control group, the tumor volume was reduced by 67%.

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Abstract

The invention discloses a jujube processed product capable of improving colon cancer and / or rectal cancer immunotherapy effects and a using method thereof. The invention claims the protection of an application of the jujube processed product in the preparation of products for intensive immunotherapy of colon cancer and / or rectal cancer. The invention also claims the protection of an application ofthe jujube processed product in the preparation of products capable of improving the antitumor effects of PD-1 / PD-L1. The invention also claims the protection of an application of the jujube processed product in combination with a PD-1 / PD-L1 inhibitor in the preparation of products capable of improving the anti-tumor effects of PD-1 / PD-L1. By using the jujube processed product and the using method provided by the invention, the tumor of MC38 colon cancer mice can be significantly reduced compared with the control group treated with PD-L1 alone.

Description

technical field [0001] The invention belongs to the field of medicinal efficacy of natural products, and in particular relates to a processed jujube product capable of improving the immunotherapy effect of colon cancer and / or rectal cancer and a use method thereof. Background technique [0002] Colon cancer and rectal cancer are malignant tumors that mainly occur in the mucosal epithelium of the colon and rectum, with more than 1 million cases and 500,000 deaths each year. In the 2017.V1 version of the "NCCN Guidelines for the Diagnosis and Treatment of Colorectal Cancer", the immunosuppressive molecules PD-1 monoclonal antibody Pembrolizumab and Nivolumab are recommended for the immunotherapy of colorectal cancer with dMMR / MSI-H molecular phenotype. In a published study of anti-PD-1 immunotherapy (NCT01876511), it was shown that PD-1 monoclonal antibody has made a breakthrough in the immunotherapy of colorectal cancer. [0003] However, clinical use shows that when PD-1 / PD...

Claims

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Application Information

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IPC IPC(8): A61K36/725A61K45/06A61K39/395A61P35/00A61P37/04
CPCA61K36/725A61K39/39566A61K45/06A61P35/00A61P37/04A61K2300/00
Inventor 蒋国强王洛洋景楠刘雪润汤志刚付佳刘铮
Owner 新疆天辰智慧信息科技有限公司
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