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Il-10, s100b and h-fabp markers and their use in detecting traumatic brain injury

A marker and biomarker technology, applied in measurement devices, biological tests, material inspection products, etc., can solve problems such as low sensitivity and infeasibility

Pending Publication Date: 2020-02-07
UNIVERSITY OF GENEVA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Therefore, the cut-off values ​​defined for this type of test need to be biased towards very high specificity (close to 100%), which may then lead to very low sensitivity
This limitation has rendered known individual biomarkers of mTBI infeasible for routine diagnosis in clinical settings

Method used

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  • Il-10, s100b and h-fabp markers and their use in detecting traumatic brain injury
  • Il-10, s100b and h-fabp markers and their use in detecting traumatic brain injury
  • Il-10, s100b and h-fabp markers and their use in detecting traumatic brain injury

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Embodiment

[0090] The following examples are intended to illustrate the present invention in more detail, but should not be construed as limiting in any sense.

[0091] Blood IL10, H-FABP, and S100B levels were quantified and compared using ELISA analysis in patients with or without brain injury on CT scan and Glasgow Coma Scale >13 within 6 hours of TBI onset. The study population consisted of 97 individuals in total.

[0092] ELISA was performed with IL10 from Mesoscale (US), H-FABP from Hycult (NL) and S100B from Abnova (TW). Each plasma sample was assayed in duplicate and randomly distributed on the plate.

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Abstract

The invention relates to IL-10, S100B or H-FABP as biomarkers or a combination of these biomarkers and their use in detecting traumatic brain injury or mild traumatic brain injury (mTBI).

Description

technical field [0001] The present invention relates to biomarkers and novel biomarkers, and their use in the diagnosis of brain injury or brain-related injuries, especially in the diagnosis of mild traumatic brain injury (mTBI), and to the use of biomarkers in individuals Methods and devices for detecting traumatic brain injury. Background technique [0002] Brain injury has a high incidence worldwide. Mild traumatic brain injury (mTBI), in particular, has a significant morbidity worldwide and is responsible for high medical costs. In contrast to severe TBI, mTBI is not overtly detectable, and therefore computed tomography (CT) scans are usually performed before confirming or ruling out serious brain injury. [0003] Identifying which patients with multiple neurological injuries, especially mild traumatic brain injury (mTBI), can be safely sent home remains a challenge. Therefore, computed tomography (CT) scans are the main tool today for detecting brain damage in these ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N33/68
CPCG01N33/6869G01N33/6896G01N2800/28G01N33/6872
Inventor J-C·桑切斯
Owner UNIVERSITY OF GENEVA
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