Use of sulfoxide compounds in preventing radiotherapy complications of thoracic and abdominal tumors

A technology of sulfoxides and compounds, applied in the field of medicine, can solve the problems of complex pathogenesis, lack of specific prevention and treatment drugs, affecting the quality of life of patients, etc.

Inactive Publication Date: 2020-01-31
BEIJING WEILANZHIYUAN MEDICAL TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

According to reports, the incidence of severe exocrine pancreatic insufficiency (EPI) after high-dose and less-fractionated mode radiation therapy with helical tomographic radiation therapy (TOMO) was 73.3%, which seriously affected the quality of life of patients.
[0006] Radiation heart injury, radiation pancreas injury, and radiation gastritis are the main dose-limiting tissues and organs in radiotherapy for thoracic and abdominal tumors. The pathogenesis is complex, and there is still a lack of specific prevention and treatment drugs
Traditional treatment methods such as hyperbaric oxygen, glucocorticoids, and surgery can effectively relieve the clinical symptoms of patients, but cannot reverse the process of radiation injury

Method used

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  • Use of sulfoxide compounds in preventing radiotherapy complications of thoracic and abdominal tumors
  • Use of sulfoxide compounds in preventing radiotherapy complications of thoracic and abdominal tumors
  • Use of sulfoxide compounds in preventing radiotherapy complications of thoracic and abdominal tumors

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0133] Example 1. The protective effect of DMSO on myocardial cell injury in mice exposed to chest

[0134] 1. Experiment group 1:

[0135] Male C57 mice were randomly selected and divided into the following 4 groups:

[0136] Non-irradiated control group (Non-IR): 6;

[0137] Non-irradiated DMSO group (Non-IR): 50% DMSO saline was administered intragastrically, 0.2ml each, the dose was 10g / kg, 6 mice;

[0138] Irradiation control group (Vehicle): 0.9% saline intragastrically, 0.2ml each, 6 each time point;

[0139] Irradiated DMSO group: 50% DMSO normal saline was administered intragastrically, 0.2ml each, the dose was 10g / kg, administered 1 hour before the irradiation, 6 rats at each time point;

[0140] Radiation dose: 16.0 Gy chest radiation.

[0141] 2. Experiment Group 2:

[0142] Male C57 mice were randomly selected and divided into the following 3 groups:

[0143] Non-irradiated control group (Non-IR): 6;

[0144] Irradiation control group: 0.9% normal saline intragastrically, 0.2ml e...

Embodiment 2

[0159] Example 2. The protective effect of DMSO on pancreatic cell damage in mice exposed to abdomen

[0160] 1. Experiment group 1:

[0161] Male C57 mice were randomly selected and divided into the following 3 groups:

[0162] Non-irradiated control group (Non-IR): 6;

[0163] Irradiation control group (Vehicle): 0.9% saline intragastrically, 0.2ml each, 6 each time point;

[0164] Irradiated DMSO group: 50% DMSO normal saline was administered intragastrically, 0.2ml each, the dose was 10g / kg, administered 1 hour before the irradiation, 6 rats at each time point;

[0165] Irradiation dose: 14.0 Gy abdominal irradiation.

[0166] 2. Experiment Group 2:

[0167] Male C57 mice were randomly selected and divided into the following 3 groups:

[0168] Irradiation control group (Vehicle): 0.9% saline intragastrically, 0.2ml each, 6 mice at each time point;

[0169] Irradiated DMSO 5g / kg group: 50% DMSO normal saline was administered intragastrically, 0.2ml each at a dose of 5g / kg, administered 1 ...

Embodiment 3

[0185] Example 3. The protective effect of DMSO on gastric mucosal injury in mice exposed to chest and abdomen

[0186] 1. Experiment grouping:

[0187] Male C57 mice were randomly selected and divided into the following 3 groups:

[0188] Non-irradiated control group (Non-IR): 3;

[0189] Irradiation control group (Vehicle): 0.9% saline intragastrically, 0.2ml each, 3 rats;

[0190] Irradiated DMSO group: 50% DMSO saline was administered intragastrically, 0.2ml each, the dose was 10g / kg, administered 1 hour before irradiation, 3 mice;

[0191] Irradiation dose: 15.0 Gy chest and abdomen irradiation.

[0192] 2. Experimental method:

[0193] See section 1.2 of "Materials and Methods"

[0194] 3. Experimental results:

[0195] Gastric mucosa is composed of epithelial layer, lamina propria and muscularis mucosa. The epithelial layer is located on the inner surface of the gastric mucosa and is a single layer of columnar epithelium. The depression of stomach epithelium constitutes a large numb...

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Abstract

The invention provides a use of sulfoxide compounds in preparing drugs for preventing humans, with thoracic and abdominal tumors, to be subjected to radiotherapy from being attacked by radioactive cardiac injury, radioactive pancreatic injury and radioactive gastritis. The sulfoxide compounds have the excellent effect in preventing the humans with the thoracic and abdominal tumors from being attacked by the radioactive cardiac injury, the radioactive pancreatic injury and the radioactive gastritis.

Description

[0001] This application claims the priority of the Chinese application 201810800390.9 entitled "Use of dimethyl sulfoxide in the prevention of radioactive oral mucositis" filed on July 20, 2018, the content of which is incorporated into this application by reference. Technical field [0002] The present invention relates to the field of medicine, in particular to the use of sulfoxide compounds, especially dimethyl sulfoxide in the prevention of radiation heart injury, radiation pancreatic injury and radiation gastritis in tumor subjects who will receive radiotherapy. Background technique [0003] Tumor radiotherapy is a local treatment method that uses radiation to treat tumors. While the radiation kills tumor cells, it also has a killing effect on normal cells, causing damage to the irradiated tissues and organs and various complications. Radiation-induced heart injury or radiation-induced heart disease (RIHD) is a serious side effect that often occurs when patients with thoracic...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/10A61P9/00A61P9/10A61P1/18A61P1/16A61P1/00A61P13/12
CPCA61K31/10A61P9/00A61P9/10A61P1/18A61P1/16A61P1/00A61P13/12A61K47/20A61P1/04A61P1/02A61P25/02A61P25/00A61P25/28
Inventor 从玉文善亚军
Owner BEIJING WEILANZHIYUAN MEDICAL TECH CO LTD
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