A high voltage ultrashort pulse power supply for tumor ablation

Abstract

The invention relates to a high-voltage ultra-short pulse power supply for tumor ablation, including a measurement and control unit, a radio frequency modulator, an isolation transformer, a demodulator and a waveform generator, wherein the first input end of the measurement and control unit is connected to an electrocardiogram detector , the second input terminal of the measurement and control unit is connected to the electrode pin, the first output terminal of the measurement and control unit is connected to the input terminal of the radio frequency modulator, the output terminal of the radio frequency modulator is connected to the input terminal of the demodulator through an isolation transformer, and the demodulator The output terminal of the measurement and control unit is connected to the electrode needle through the waveform generator, the second output terminal of the measurement and control unit is connected to the demodulator, and the third output terminal of the measurement and control unit is connected to the waveform generator. Compared with the prior art, the present invention adopts the combination of the isolation transformer and the combination module to realize the electrical isolation inside the high-voltage ultra-short pulse power supply, improve the safety of use, and realize independent setting of multiple output pulses by configuring multiple sets of circuits , so that the output high-voltage ultra-short pulse can be modulated, thereby expanding the scope of application.

Description

technical field [0001] The invention relates to the technical field of medical devices, in particular to a high-voltage ultrashort pulse power supply for tumor ablation. Background technique [0002] High-voltage square-wave pulsed electric field tumor therapy device (nanoknife) is a brand-new cutting-edge tumor ablation device, which uses electric field energy and based on the principle of irreversible electroporation to transmit high-voltage electric field to tumor cells in the form of micropulses to change the cell transmigration. The membrane potential creates nanoscale pores on the lipid bilayer cell membrane, increases the permeability of the cell membrane, causes irreversible electroporation of tumor cells in the target area, and eventually leads to tumor death. Specifically, an electrode needle with a diameter of 1 mm is inserted into the tumor through the skin, and the size and position of the expected electric field are calculated and drawn by computer technology, ...

AI Technical Summary

Problems solved by technology

[0003] At present, the high-voltage ultra-short pulse power supply used for electrode needles is mainly direct discharge type, such as figure 1 As shown, the energy storage capacitor C is connected in parallel at both ends of the power supply V, one end of the energy storage capacitor C is connected to the input terminal of the trigger circuit through the high-voltage power switch Q, and the output terminal of the trigger circuit is connected to the resistor Z L One end of the resistor Z L The other end of is connected to the other end of the energy storage capacitor C, where the resistor Z L It represents the resistance of the human body. The amplitude of the high-voltage ultra-short pulse is determined by the voltage of the power supply V, and the pulse repetition frequency, pulse width and pulse number are determined by the trigger circuit. As a result, the output high-voltage ultra-short pulse cannot be independently set and cannot be directly applied to Ablation of tumors of different shapes or sizes; the direct discharge high-voltage ultra-short pulse power supply mainly uses the high-voltage power switch Q for direct discharge, which is easy to generate the required output waveform, but there is a great potential safety hazard. Once the high-voltage power switch is discharged When Q breaks down, all the energy in the storage capacitor C will be released to the resistor Z L , resulting in medical malpractice

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