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Preparation method of shape memory polymer material with drug release function, product obtained therethrough, and application of product

A technology of polymer materials and drugs, which is applied in the field of preparation of shape memory polymer materials, can solve the problems of material mechanical strength and modulus decline, easy aggregation and precipitation of drugs, and uncontrollable drug loading, so as to improve shape memory performance and Effect of mechanical strength, high mechanical strength and high modulus

Active Publication Date: 2020-01-10
LINYI UNIVERSITY
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] In order to solve the problems existing in the prior art, the present invention provides a preparation method of a shape-memory polymer material with drug release function and the resulting product. The method is simple, convenient and time-saving, and the drug distribution of the obtained product is uniform, The drug release is highly controllable, and it has high modulus, high mechanical strength, fast recovery speed and large recovery stress, which solves the problem of shape memory polymer materials with drug release function prepared by the swelling method. There are problems such as cumbersome process, time-consuming, uncontrollable drug loading, easy aggregation and precipitation of drugs, and decrease in mechanical strength and modulus of materials after drug loading.

Method used

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  • Preparation method of shape memory polymer material with drug release function, product obtained therethrough, and application of product
  • Preparation method of shape memory polymer material with drug release function, product obtained therethrough, and application of product
  • Preparation method of shape memory polymer material with drug release function, product obtained therethrough, and application of product

Examples

Experimental program
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Effect test

Embodiment 1

[0084] 1. Polyethylene glycol-polycaprolactone-polyethylene glycol triblock copolymer (PEG) functionalized with 152.45 mmol terminal acrylate groups 2500 -PCL 4000 -PEG 2500 ) and 0.1 g of enoxacin were dissolved in 18 ml of deionized water, and ultrasonically dispersed for 60 min to make the triblock copolymer form nanomicelles, and all the drugs were dissolved in the micelles.

[0085] 2. After completely dissolving, add 3.25 g of hydroxyethyl acrylate, 1.89 g of acrylic acid and 0.064 g of photoinitiator 2, 2-dimethoxy-2-phenylacetophenone. Nitrogen gas was bubbled for 20 min to remove dissolved oxygen, and the mixed solution was slowly injected into the glass mold with a disposable syringe, and multiple molds injected with the reaction mixed solution were placed under an ultraviolet device for photocrosslinking reaction, wherein the ultraviolet light intensity was 10 mW / cm 2 . The mold was illuminated for 20 minutes before and after the mold. After the reaction was ove...

Embodiment 2

[0092]1, with embodiment 1.

[0093] 2. After it is completely dissolved, add 3.25 g of hydroxyethyl acrylate, 1.89 g of acrylic acid and 0.064 g of potassium persulfate. Nitrogen was bubbled for 20 min to remove dissolved oxygen, and the mixture was slowly injected into glass molds with a disposable syringe, and multiple molds injected with the reaction mixture were placed in an oven, and reacted at 45 °C for 12 h. After the reaction is over, the crosslinked polymer material is taken out from the mold and placed on a polytetrafluoroethylene film, dried in an oven at 60 °C for 12 h, and then raised to 80 °C for 12 h in vacuum , to obtain the shape-memory polymer material, which is a temperature-responsive or water-responsive shape-memory polymer material.

Embodiment 3

[0095] 1, with embodiment 1.

[0096] 2. After it is completely dissolved, add 3.25 g of hydroxyethyl acrylate, 1.89 g of acrylic acid and 0.064 g of potassium persulfate. Nitrogen gas was bubbled for 20 min to remove dissolved oxygen, and the mixed solution was slowly injected into the glass mold with a disposable syringe, and multiple molds injected with the reaction mixed solution were placed in a UV curing printer for photocrosslinking reaction, UV curing printer The UV light intensity is 30 mW / cm -2 , the printing speed is 50 mm / hour. The printed material was taken out from the mold and placed on a polytetrafluoroethylene film, dried in an oven at 60 °C for 12 h, and then raised to 80 °C for 12 h in vacuum to obtain the shape memory height The molecular material is a temperature-responsive or water-responsive shape memory polymer material.

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Abstract

The invention discloses a preparation method of a shape memory polymer material with a drug release function, a product obtained therethrough, and an application of the product. The preparation methodcomprises the following steps: (1) dispersing a drug and an amphiphilic triblock copolymer with a functionalized terminal double bond in a solvent, forming a nano-micelle or a nano-reverse micelle under the action of similar intermiscibility, and wrapping the drug in the nano-micelle or the nano-reverse micelle; and (2) adding a monomer and an initiator into the reaction system in step (1), and carrying out in-situ free radical polymerization to form the shape memory polymer material with the drug release function. The method has the advantages of simple operation steps, convenience and timesaving, and the obtained product has the advantages of high drug loading capacity, uniform drug distribution, high drug release controllability, high modulus, high mechanical strength, high recovery speed and high recovery stress, and overcomes the defects of the shape memory polymer material with the drug release function, which is prepared by existing swelling methods.

Description

technical field [0001] The present invention relates to a preparation method of a shape-memory polymer material with drug release function and the resulting product and application, in particular to a preparation of a shape-memory polymer material with drug release control, degradability, high resilience and rapid response The method and the obtained product and application belong to the technical field of medical functional polymer materials. Background technique [0002] Shape memory polymers (also known as shape memory polymers) are those that can sense the stimuli of changes in the external environment and respond to such changes, adjust their state parameters (such as shape, position, strain, etc.) to return to a preset state a class of polymer materials. Because of its good flexibility, large recoverable deformation, diverse stimulation methods, easy adjustment of response temperature, light weight, biodegradability, good biocompatibility, cheap price and easy process...

Claims

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Application Information

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IPC IPC(8): C08F287/00C08F220/20C08F220/06C08F220/56C08F220/54C08F220/14A61K47/34A61L27/18A61L31/06
CPCC08F287/00A61K47/34A61L27/18A61L31/06C08F220/20C08F220/06C08F220/56C08F220/54C08F220/14
Inventor 李兴建
Owner LINYI UNIVERSITY
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