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Composition with whitening effect, whitening soluble microneedle patch with high drug loading and preparation method thereof

A high drug-loading and soluble technology, applied in the field of microneedles, can solve the problems that microneedles cannot pierce the skin, low microneedle strength, and low drug-loading capacity, so as to reduce treatment costs, improve transdermal absorption rate, and improve efficacy Good results

Active Publication Date: 2022-04-29
GUANGZHOU NEWORLD PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] However, the high addition of active ingredients will directly affect the mechanical properties of the soluble microneedles, resulting in low strength and poor toughness of the microneedles, making the microneedles unable to pierce the skin and thus unable to exert their efficacy. Therefore, most of the existing soluble microneedles There is a problem of low drug loading

Method used

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  • Composition with whitening effect, whitening soluble microneedle patch with high drug loading and preparation method thereof
  • Composition with whitening effect, whitening soluble microneedle patch with high drug loading and preparation method thereof
  • Composition with whitening effect, whitening soluble microneedle patch with high drug loading and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0061] The whitening soluble microneedle patch with high drug loading provided in this embodiment is composed of a needle point and a base; the raw materials of the needle point are composed as follows (in parts by weight): 13 parts of arbutin, 15 parts of magnesium ascorbyl phosphate, 7 parts of adenosine, 0.4 parts of sturgeon caviar extract, 106.2 parts of sodium hyaluronate (molecular weight of 280kDa), 6 parts of polyvinylpyrrolidone (molecular weight of 1300kDa), 12 parts of glycerin, 6 parts of hydroxypropyl cellulose; The composition of raw materials is as follows: 1.1 parts of sodium hyaluronate (molecular weight: 280Kda), 0.1 parts of glycerin, and 0.1 parts of hydroxypropyl cellulose.

[0062] The preparation method of the whitening soluble microneedle patch with high drug loading provided in this example is as follows:

[0063] S1: Preparation of needle tips: After uniformly mixing the above-mentioned raw materials for preparing needle tips, add 591.4 parts of dist...

Embodiment 2

[0066] The whitening soluble microneedle patch with high drug loading provided in this embodiment is composed of a needle point and a base; the raw materials of the needle point are composed as follows (in parts by weight): 13 parts of arbutin, 15 parts of magnesium ascorbyl phosphate, 7 parts of adenosine, 0.4 parts of sturgeon caviar extract, 70.8 parts of hyaluronic acid (molecular weight of 280kDa), 6 parts of polyvinylpyrrolidone (molecular weight of 1300kDa), 12 parts of glycerin, 6 parts of hydroxypropyl cellulose; The composition of the raw materials is as follows: 1.1 parts of sodium hyaluronate (molecular weight: 280 kDa), 0.1 parts of glycerin, and 0.1 parts of hydroxypropyl cellulose.

[0067] The preparation method of the whitening soluble microneedle patch with high drug loading provided in this example is as follows:

[0068] S1: Preparation of needle tips: After uniformly mixing the above-mentioned raw materials for preparing needle tips, add 591.4 parts of dis...

Embodiment 3

[0071] The whitening soluble microneedle patch with high drug loading provided in this embodiment is composed of a needle point and a base; the raw materials of the needle point are composed as follows (in parts by weight): 13 parts of arbutin, 15 parts of magnesium ascorbyl phosphate, 7 parts of adenosine, 0.4 parts of sturgeon caviar extract, 35.4 parts of hyaluronic acid (molecular weight: 280kDa), 6 parts of polyvinylpyrrolidone (molecular weight: 1300kDa), 12 parts of glycerin, 6 parts of hydroxypropyl cellulose; the raw materials of the base The composition is as follows: 1.1 parts of sodium hyaluronate (molecular weight: 280 kDa), 0.1 parts of glycerin, and 0.1 parts of hydroxypropyl cellulose.

[0072] The preparation method of the whitening soluble microneedle patch with high drug loading provided in this example is as follows:

[0073] S1: Preparation of needle tips: After uniformly mixing the above-mentioned raw materials for preparing needle tips, add 591.4 parts o...

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Abstract

The invention relates to a composition with whitening effect, a whitening soluble microneedle patch with high drug loading and a preparation method thereof. The composition with whitening effect comprises the following components in parts by weight: 10-20 parts of arbutin, 10-20 parts of magnesium ascorbyl phosphate, 5-10 parts of adenosine, and 0.1-0.5 parts of sturgeon caviar extract. The whitening dissolvable microneedle patch is composed of a needle tip and a base, the needle tip is prepared from the composition with whitening effect, hyaluronic acid or its sodium salt, and microneedle auxiliary materials; the composition with whitening effect , hyaluronic acid or its sodium salt, and the mass ratio of the microneedle auxiliary material are 1:0.1-5:0.2-1; the microneedle auxiliary material is composed of polyvinylpyrrolidone, glycerin and hydroxypropyl cellulose. The whitening soluble microneedle patch has high drug loading and excellent mechanical properties, and has high whitening, blemish-lightening and moisturizing effects.

Description

[0001] field of invention [0002] The invention belongs to the field of microneedles, and in particular relates to a composition with whitening effect, a whitening soluble microneedle patch with high drug loading and a preparation method thereof. Background technique [0003] Pigmentation is a general term for all dark spots on the skin due to the stimulation of various internal and external factors. Most of them belong to brown or black pigmentation plaques formed by the increase or slow elimination of melanin synthesis on the surface of the skin. Pigmentation occurs mostly on the cheeks and forehead, seriously affecting the beauty of the face. Today’s whitening products on the market usually achieve whitening and lightening effects by adding skin whitening agents to the products. The mechanism of action of skin whitening agents is usually to target tyrosinase, inhibit tyrosinase activity, synthesis and migration, Or cytotoxic to melanocytes to inhibit melanin pigmentation....

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K8/60A61K8/67A61K8/98A61K8/73A61K8/81A61K8/34A61Q19/02A61Q19/00A61Q19/08A61M37/00
CPCA61K8/602A61K8/676A61K8/987A61K8/735A61K8/8176A61K8/345A61K8/731A61Q19/02A61Q19/00A61Q19/08A61M37/0015A61K2800/782A61K2800/592A61K2800/5922A61M2037/0023A61M2037/0046A61M2037/0053A61M2037/0061
Inventor 温新国张敏敏陈叶盛陈航平任春艳
Owner GUANGZHOU NEWORLD PHARMA CO LTD
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