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Pesticide composition based on niclosamide ethanolamine salt and preparation method thereof

A technology of spiroxamine ethanolamine salt and pesticide composition, which is applied in the field of pesticide composition based on spiroxamine ethanolamine salt and its preparation, can solve the problem of low crushing efficiency and purity of solid materials, affecting the efficacy of the finished composition, and inability to exert Molluscicide effect and other problems, to achieve the effect of improving crushing efficiency and dimensional stability, improving water-soluble slow-release effect, and excellent low-temperature fluidity

Pending Publication Date: 2020-01-03
ANHUI TOPSUN PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But there are following technical problems: 1) when it is prepared into a dry suspension dosage form, the solid content is low, the high and low temperature stability is poor, and the molluscicide effect and drug effect maintenance time need to be further strengthened; , due to the single killing mechanism, the stable molluscicide effect cannot be brought into play; 3) grinding and pulverization is adopted during preparation, and the pulverization efficiency and purity of solid materials are low, which affects the drug effect of the finished composition

Method used

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  • Pesticide composition based on niclosamide ethanolamine salt and preparation method thereof
  • Pesticide composition based on niclosamide ethanolamine salt and preparation method thereof
  • Pesticide composition based on niclosamide ethanolamine salt and preparation method thereof

Examples

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Effect test

Embodiment 1

[0036] A pesticide composition based on spiroxamine ethanolamine salt, comprising the following components by weight: 62 parts of spiroxamine ethanolamine salt, 6 parts of wetting agent, 3 parts of hyperbranched polyamide ester, 1.2 parts of organosiloxane defoaming agent Agent, 1.5 parts of ethylene glycol butyl ether, 10 parts of sodium alginate.

[0037] The preparation method of the wetting agent is as follows: 1) In parts by weight, weigh 35 parts of branched chain alkyl polyol comb structure ethoxy ether and 16 parts of polyvinyl alcohol, stir at room temperature at 260r / min for 1.5h, and obtain mixture a;

[0038] 2) In parts by weight, weigh 1.6 parts of tea saponin, 0.4 parts of nano-molecular sieves, and 8 parts of ethanol, stir at a speed of 400 r / min for 26 minutes, and aseptically dry to obtain a sustained-release tea saponin;

[0039] 3) In terms of parts by weight, weigh 1.8 parts of glycerol trihydroxy polyether, mix it with mixture a and tea saponin slow-rele...

Embodiment 2

[0049] A pesticide composition based on spiroxamine ethanolamine salt, comprising the following components by weight: 68 parts of spiroxamine ethanolamine salt, 7 parts of wetting agent, 4 parts of hyperbranched polyamide ester, 0.8 part of higher alcohol fatty acid ester Compound defoamer, 1.7 parts of diethylene glycol, 6 parts of bentonite.

[0050] The preparation method of the wetting agent is as follows: 1) In parts by weight, weigh 37 parts of branched chain alkyl polyol comb structure ethoxy ether and 16 parts of polyvinyl alcohol, stir at room temperature at 280r / min for 1.5h , to obtain mixture a;

[0051] 2) In parts by weight, weigh 1.4 parts of tea saponin, 0.4 parts of nano-molecular sieves, and 9 parts of ethanol, stir at a speed of 420 r / min for 30 minutes, and aseptically dry to obtain a sustained-release tea saponin;

[0052] 3) In terms of parts by weight, weigh 2.5 parts of glycerol trihydroxypolyether, mix with mixture a and tea saponin slow-release produ...

Embodiment 3

[0055] A pesticide composition based on spiroxamine ethanolamine salt, comprising the following components by weight: 72 parts of spiroxamine ethanolamine salt, 7 parts of wetting agent, 4 parts of hyperbranched polyamide ester, 1.2 parts of organic silicone defoaming agent Agent, 2 parts of propylene glycol butyl ether, 11 parts of light calcium carbonate.

[0056] The preparation method of the wetting agent is as follows: 1) In parts by weight, weigh 33 parts of branched chain alkyl polyol comb structure ethoxy ether and 15 parts of polyvinyl alcohol, stir at room temperature at 300r / min for 1.2h , to obtain mixture a;

[0057] 2) In parts by weight, weigh 1.5 parts of tea saponin, 0.5 parts of nano-molecular sieves, and 9 parts of ethanol, stir at a speed of 460 r / min for 30 minutes, and aseptically dry to obtain a sustained-release tea saponin;

[0058] 3) In terms of parts by weight, weigh 2.2 parts of glycerol trihydroxypolyether, mix it with mixture a and tea saponin s...

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Abstract

The invention discloses a pesticide composition based on niclosamide ethanolamine salt and a preparation method thereof, and relates to the technical field of molluscacidal preparations. The pesticidecomposition is prepared from niclosamide ethanolamine salt, a wetting agent, hyperbranched polyesteramide, a defoaming agent, an antifreeze agent and filler; a dry suspending agent type is obtained through the working procedures of premixing, airflow crushing, spray drying and granulation; on the basis of the prior art, the hyperbranched polyesteramide is used as a dispersant, and the dispersanthas a special branched molecular structure, more functional groups on the surface of a molecule can firmly wrap and adsorb the niclosamide ethanolamine salt, the bridging effect cannot occur, and thesolid content of a dry suspending agent system is effectively improved. The agricultural composition has good suspension rate and qualified high-low temperature stability, a suspending agent can be formed after the agricultural composition is mixed with water; the molluscicidal effect and the drug effect maintenance time of the composition are improved under the slow-release synergistic effect ofthe tea saponin after being sprayed and applied, and the agricultural composition is suitable for industrial application.

Description

technical field [0001] The invention relates to the technical field of molluscicide preparations, in particular to a pesticide composition based on spiroxamine ethanolamine salt and a preparation method thereof. Background technique [0002] Spirocidal ethanolamine salt, chemical name: N-(2-chloro-4-nitrophenyl)-2-hydroxyl-5-chlorobenzoylethanolamine, is a molluscicide with stomach poisoning effect. Snails, snail eggs, schistosome cercariae, etc. have a strong killing effect, low toxicity to humans and animals, safe to crops, easy to use, and can be directly diluted with water. Because of its strong molluscicidal effect and low toxicity to mammals, spiramine ethanolamine salt has become the world-recognized first-choice agent for killing snails and preventing schistosomiasis, and is clinically used as an anthelmintic. [0003] The prior art (CN108719290A) discloses a dry suspension of spiroxamine ethanolamine salt and a preparation method thereof. The dry suspension compris...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A01N37/40A01N25/14A01P9/00B01J2/16
CPCA01N37/40A01N25/14B01J2/16
Inventor 黄梅李文新柏如忠
Owner ANHUI TOPSUN PHARMA
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