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Tissue-engineered cornea and preparation method thereof

A tissue engineering and cornea technology, applied in the field of tissue engineering cornea and its preparation, can solve the problems of high corneal plaque, lack of patients, and inability to restore the cornea, so as to improve the success rate of transplantation, reduce the probability of rejection, and reduce the incidence of rejection. The effect of good mechanical properties

Active Publication Date: 2019-12-27
SHENZHEN GRADUATE SCHOOL TSINGHUA UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the high degree of plaque scarcity of donated corneas, most patients cannot receive corneal transplants and cannot recover their eyesight.

Method used

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  • Tissue-engineered cornea and preparation method thereof
  • Tissue-engineered cornea and preparation method thereof
  • Tissue-engineered cornea and preparation method thereof

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Embodiment Construction

[0027] Embodiments of the present invention will be described in detail below. It should be emphasized that the following description is only exemplary and not intended to limit the scope of the invention and its application.

[0028] refer to Figure 1 to Figure 3 , in one embodiment, a tissue engineered cornea 1a, 1b, 1c, comprising a laminated structure of at least three layers, wherein each layer 11, 12 is a fiber prepared by electrospinning or electrostatic direct writing or photocuring 3D printing Scaffolds 2a, 2b, 2c, 2d, 2e, 2f, 2g, 2h are composite layers formed by solidification and compounding of one or more of collagen, acellular matrix, and silk fibroin, and corneal stroma is inoculated between adjacent two layers Cells 21, 23, 25, 27 and neurons 22, 24, 26, 28, said corneal stromal cells 21, 23, 25, 27 and said neurons 22, 24, 26, 28 may be along the fibers of the scaffold Corneal stromal cells between two adjacent layers secrete extracellular matrix to form a ...

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Abstract

The invention discloses a tissue-engineered cornea and a preparation method thereof. The tissue-engineered cornea comprises three or more layers of laminated structures, each layer of the laminated structure is a composite layer formed in the mode that a fiber scaffold prepared by electrospinning or electrostatic direct writing or light curing 3D printing is cured and composited with one or more of collagen, an acellular matrix and silk fibroin, the space between every two adjacent layers is inoculated with corneal stromal cells and neurons, the corneal stromal cells and the neurons can grow in the direction of fibers of the scaffold, the corneal stromal cells between every two adjacent layers secrete extracellular matrixes to form a tissue structure similar to the human corneal stroma, and the upper surfaces and the lower surface of the laminated structures are inoculated with corneal epithelial cells and corneal endothelial cells. The tissue-engineered cornea can simulate the corneastructure well, is easy to prepare and good in biocompatibility and is easily fused with tissue.

Description

technical field [0001] The invention relates to the technical field of tissue engineering, in particular to a tissue engineering cornea and a preparation method thereof. Background technique [0002] Corneal disease is a common and frequently-occurring disease in ophthalmology. The blindness rate of corneal disease ranks second in the epidemiological survey of blindness. Corneal transplantation is the only effective way to treat corneal blindness. However, due to the high lack of donated corneas, the vast majority of patients cannot receive corneal transplantation and cannot recover their eyesight. In recent years, the rise and development of corneal tissue engineering has created conditions for the in vitro reconstruction and clinical application of tissue engineered corneas, and has also brought new hope for blind patients with corneal diseases through tissue engineered cornea transplantation, but how to obtain The ideal carrier scaffold is still a hotspot and difficulty ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/16A61L27/18A61L27/22A61L27/24A61L27/36A61L27/38A61L27/40A61F2/14
CPCA61F2/142A61L27/16A61L27/18A61L27/222A61L27/227A61L27/24A61L27/3604A61L27/3804A61L27/383A61L2430/16C08L89/00
Inventor 弥胜利王杰琼
Owner SHENZHEN GRADUATE SCHOOL TSINGHUA UNIV
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