A kind of preparation method of magnolol extract solid dispersion

Abstract

The invention provides a preparation method of magnolol extract solid dispersion, which comprises the following steps: take magnolol extract freeze-dried powder and carrier, dissolve in ethanol solution, remove ethanol solution by rotary evaporation, dry, pulverize , that is, the carrier is composed of polyethylene glycol and poloxamer. The preparation method of the magnolol extract solid dispersion of the present invention can prepare the magnolol extract solid dispersion with a high dissolution rate, which is conducive to improving the total dissolution rate of magnolol and honokiol, the main active ingredients of Magnolia officinalis, Improve its water solubility, increase the utilization rate of magnolia bark, facilitate further refining of magnolia bark-related preparations, and expand clinical application.

Description

technical field [0001] The present invention relates to a preparation method of Magnolia officinalis alcohol extract solid dispersion. Background technique [0002] Magnolia officinalis is the dried bark, root bark and branch bark of Magnolia officinalis Magnolia officinalis Rehd.et Wils and Magnolia officinalis Rehd.et Wils.var.biloba Rehd.et Wils. Magnolia is bitter, acrid, and warm in nature. Returns to the spleen, stomach, lung, and large intestine meridians. With dry dampness and phlegm, lower gas in addition to full. For dampness stagnation injury, epigastric vomiting and diarrhea, food accumulation of qi stagnation, abdominal distention and constipation, phlegm and cough. The main active ingredients in Magnolia, such as honokiol and honokiol, are insoluble in water, and their oral bioavailability is still low, which limits the development of related product formulations and affects clinical applications. At present, the research also mostly improves the dissolutio...

AI Technical Summary

Problems solved by technology

The main active ingredients in magnolia bark, such as magnolol and honokiol, are insoluble in water, and their oral bioavailability is still low, which limits the development of related product preparations and affects clinical application

At present, most studies focus on improving the dissolution rate of monomer components, ignoring the characteristics of the overall effect of multiple components in traditional Chinese medicine.

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