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Covalent organic framework material with photodynamic therapy effects and preparation method thereof

A covalent organic framework, photodynamic therapy technology, applied in photodynamic therapy, medical preparations containing active ingredients, wave energy or particle radiation treatment materials, etc., to achieve good photodynamic therapy effect, excellent tumor photodynamic therapy Effect, effect of excellent ROS generation performance

Inactive Publication Date: 2019-11-29
WUHAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, these studies are based on the selection of photosensitizer monomers that have excellent ROS-generating properties, and those monomer molecules that do not have ROS-generating properties have not been studied, which is also a major difficulty in the field of photodynamic therapy for cancer.

Method used

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  • Covalent organic framework material with photodynamic therapy effects and preparation method thereof
  • Covalent organic framework material with photodynamic therapy effects and preparation method thereof
  • Covalent organic framework material with photodynamic therapy effects and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] Step 1): Weigh 25.9 mg, 0.24 mmol of p-phenylenediamine and 0.12 mmol of monomer L-3C dissolved in 1.5 ml of o-dichlorobenzene and 1.5 ml of n-butanol in a glass tube, and ultrasonically disperse it evenly;

[0031] Step 2): Add 0.3ml of 6M acetic acid aqueous solution to the glass tube, freeze the glass tube in 77K liquid nitrogen, then pump it to a vacuum of 30Pa with a double-row tube, then warm it up to room temperature, and then pass in argon again Place the glass tube in liquid nitrogen at 77K and freeze it with a double-row tube to evacuate to a vacuum of 30 Pa. After 3 cycles of this operation, seal the glass tube with a flame gun to prevent air leakage, and place the sealed glass tube at 90°C placed in a constant temperature oven for 7 days;

[0032] Step 3): After 7 days, take out the glass tube and wait for the temperature to drop to room temperature, then open the glass tube and filter the reaction solution to obtain a solid, then use the Soxhlet extraction ...

Embodiment 2

[0034] Step 1): Weigh 0.25 mmol of p-phenylenediamine and 0.15 mmol of monomer L-3N dissolved in 1.5 ml of o-dichlorobenzene and 1.5 ml of n-butanol in a glass tube, and ultrasonically disperse it evenly;

[0035] Step 2): Add 0.3ml of 10M acetic acid aqueous solution to the glass tube, place the glass tube in 100K liquid nitrogen to freeze, then evacuate to a vacuum of 50Pa with a double-row tube, then warm up to room temperature and then pass in argon again Place the glass tube in liquid nitrogen of 100K and freeze it with a double-row tube to evacuate to a vacuum of 50 Pa. After 3 cycles of this operation, seal the glass tube with a flame gun to prevent air leakage, and place the sealed glass tube at 120°C placed in a constant temperature oven for 3 days;

[0036] Step 3): After 3 days, take out the glass tube and wait for the temperature to drop to room temperature, then open the glass tube and filter the reaction solution to obtain a solid, then use the Soxhlet extraction...

Embodiment 3

[0038] Step 1): Weigh 0.24 mmol of p-phenylenediamine and 0.13 mmol of monomer L-3C dissolved in 1 ml of o-dichlorobenzene and 1 ml of n-butanol in a glass tube, and ultrasonically disperse it evenly;

[0039] Step 2): Add 0.3ml of 6M acetic acid aqueous solution to the glass tube, place the glass tube in 85K liquid nitrogen to freeze, then use a double-row tube to evacuate to a vacuum of 40Pa, then heat it up to room temperature and then pass in argon again Place the glass tube in liquid nitrogen of 85K and freeze it with a double-row tube to evacuate to a vacuum of 40Pa. After this operation cycle for several times, seal the glass tube with a flame gun to prevent air leakage, and place the sealed glass tube at 110°C placed in a constant temperature oven for 5 days;

[0040] Step 3): After 5 days, take out the glass tube and wait for the temperature to drop to room temperature, then open the glass tube and filter the reaction solution to obtain a solid, then use the Soxhlet e...

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Abstract

The invention relates to the technical field of synthesizing covalent organic framework materials with photodynamic therapeutic effects, and in particular relates to a covalent organic framework material with photodynamic therapeutic effects and a preparation method thereof. The molecular structural formula of the covalent organic framework material with photodynamic therapeutic effects is as shown in the specification, the covalent organic framework material with photodynamic therapeutic effects has high crystalline state, specific surface area, small biological toxicity and a particle size of about 100 nm, and is very suitable for biological experiments; according to the invention, after monomers which do not have the capability of generating active oxygen are assembled into corresponding two-dimensional COF samples, the capability of generating the active oxygen is obviously enhanced, and the capability of generating the active oxygen of the covalent organic framework material is better than that of the classical porphyrin metal organic framework (MOF) and PCN 224, and the covalent organic framework material has excellent photodynamic therapy effect.

Description

technical field [0001] The invention relates to the technical field of synthesizing a covalent organic framework material with a photodynamic therapy effect, in particular to a covalent organic framework material with a photodynamic therapy effect and a preparation method thereof. Background technique [0002] Photodynamic therapy (PDT) is a new type of tumor treatment recently approved by many countries, bringing hope to millions of new cancer patients every year. Compared with traditional treatment methods (such as chemotherapy, radiation therapy, and surgery), PDT has the advantages of non-invasiveness and operational accuracy, which lead to its advantages of low recurrence rate, small side effects, and no radiation. The core of PDT is to select a suitable photosensitizer to achieve efficient generation of reactive oxygen species (ROS) under laser irradiation to successfully kill cancer cells. Among them, molecular-based photosensitizers are widely used in PDT due to the...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08G83/00A61K41/00A61P35/00
CPCA61K41/0057A61P35/00C08G83/008
Inventor 邓鹤翔张亮
Owner WUHAN UNIV
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