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Step-by-step controlled-release intelligent capsule, preparation method and 3D printing system

A 3D printing and capsule technology, which is applied in the field of medicine, can solve the problems of complex production process and single function, and achieve the effect of simple process, improved processing efficiency and easy promotion

Active Publication Date: 2019-11-29
JILIN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the preparation method of sustained and controlled release capsules is mainly to use solid dispersion technology to make the drugs in the capsules into carriers or coatings of materials with different release rates, such as water-insoluble polymers, enteric materials, lipid materials, etc. To prepare sustained-release capsules, the production process is relatively complicated and has a single function

Method used

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  • Step-by-step controlled-release intelligent capsule, preparation method and 3D printing system
  • Step-by-step controlled-release intelligent capsule, preparation method and 3D printing system
  • Step-by-step controlled-release intelligent capsule, preparation method and 3D printing system

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preparation example Construction

[0051] The present invention also provides a method for preparing the above-mentioned stepwise controlled-release smart capsule, comprising the following steps:

[0052] Step 1: Put the printing ink and the drug into the slurry tube 5-1 as slurry respectively;

[0053] Step 2: According to the structure of the step-by-step controlled-release smart capsule, use modeling software to establish a three-dimensional solid model, export the STL file and slice the step-by-step smart capsule model through the slicing software;

[0054] Step 3: Input the STL format file into the 3D printing system. After setting the parameters on the host computer 1, the parameters are preferably that the outlet diameter of the extrusion head is 0.34mm-0.6mm, and the extrusion speed is 20mm / s-30mm / s s, the filling rate is 92% to 100%, and the printing layer thickness is 0.1mm to 0.5mm; start the 3D printing system, and the pressure controller 3 controls the slurry in the slurry tube 5-1 to be extruded f...

Embodiment 1

[0065] Figure 6 Schematic diagram of "onion-shaped" step-by-step controlled-release smart capsules printed for extrusion molding 3D printing technology, such as Figure 6 As shown, it specifically includes the following steps:

[0066] 1. Material preparation:

[0067] (1) Preparation of gelatin 3D printing ink: According to the mass ratio of gelatin: glycerin: water = 1:0.35:1.30, the above materials are mixed evenly, heated to 85°C in a hot water bath, and vacuum degassed under stirring to obtain Uniform glue solution, then add 0.5% (w / v) carboxylated cellulose nanofibers to the glue solution, after fully stirring, the gelatin ink of 3D printing is obtained;

[0068] (2) Preparation of sodium alginate 3D printing ink: Mix the above materials evenly with the ratio of sodium alginate: sodium carboxymethyl cellulose = 6:1 according to the mass ratio, and then use distilled water sol, the sol temperature is 55 ° C, Add polyethylene glycol solution-400 during the sol process,...

Embodiment 2

[0079] Figure 7 Schematic diagram of the process stages of printing "sugarcane-child compound type" step-by-step controlled-release smart capsules for extrusion molding 3D printing technology, Figure 8 Schematic diagram of the end stage of the "sugarcane-child compound" step-by-step controlled-release smart capsule printed by extrusion 3D printing technology, as shown in Figure 7 and Figure 8 As shown, it specifically includes the following steps:

[0080] 1. Material preparation:

[0081] (1) Preparation of gelatin 3D printing ink: According to the mass ratio of gelatin: glycerin: water = 1:0.35:1.30, the above materials are mixed evenly, heated to 85°C in a hot water bath, and vacuum degassed under stirring to obtain Uniform glue solution, then add 0.5% (w / v) carboxylated cellulose nanofibers to the glue solution, after fully stirring, to obtain gelatin ink suitable for 3D printing;

[0082] (2) Preparation of sodium alginate 3D printing ink: Mix the above materials ...

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Abstract

The invention provides a step-by-step controlled-release intelligent capsule, a preparation method and a 3D printing system and belongs to the technical field of medicines. The intelligent capsule isprepared by using a 3D printing technique. The structure of the intelligent capsule is selected from one of a mother and child type, an onion type, a sugarcane type, a sugarcane-mother and child composite type and an onion-mother and child composite type. The invention further provides a preparation method of the step-by-step controlled-release intelligent capsule. The invention further provides a3D printing system which comprises a main machine, a platform controller, a pressure controller, a platform unit, a multi-extrusion head supply unit, a base plate and a sealing cabin. By adopting thestep-by-step controlled-release intelligent capsule provided by the invention, medicines can be slowly released within a preset period, and the medicine utilization rate can be increased. The processis simple, the processing cycle can be shortened, the 3D printing system provided by the invention is applicable to 3D printing of different structure samples, and the processing efficiency can be improved.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a step-by-step controlled-release smart capsule, a preparation method and a 3D printing system. Background technique [0002] An important problem with traditional drug administration and drug delivery methods, such as injections, tablets, creams, etc., is that the drug concentration is higher than the required maximum dose in a short period of time, and the drug concentration is maintained in the body for a short time, requiring multiple times Drug administration, thereby increasing the cost of treatment and toxic side effects on normal tissues. Therefore, this traditional drug delivery method cannot meet the needs of clinical application. [0003] The drug sustained and controlled release system has been greatly developed in the field of health care science. The drug sustained and controlled release system can slowly release the drug within a predetermined period ...

Claims

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Application Information

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IPC IPC(8): A61K9/64A61K47/42A61K47/36A61K47/38A61K31/7052A61K31/192A61K31/496A61J3/07B33Y10/00B33Y30/00B33Y70/00B33Y80/00
CPCA61K9/4825A61K9/4816A61K47/36A61K47/38A61K31/7052A61K31/192A61K31/496A61J3/078A61J3/071B33Y10/00B33Y30/00B33Y70/00B33Y80/00A61J2200/20A61K2300/00
Inventor 张志辉祖硕刘庆萍宋文龙周升柱周艢刘镇宁赵杰梁云虹于征磊王淇
Owner JILIN UNIV
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