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Oat total alkaloid, anti-skin-allergy composition and preparation method of anti-skin-allergy composition

A technology for total alkaloids and skin allergies, which is applied in the fields of natural product chemistry and medicine, can solve problems such as high viscosity, high boiling point, and large heat and mass transfer resistance, and achieve simple operation methods, high extraction efficiency, and small equipment investment Effect

Inactive Publication Date: 2019-11-22
SHENZHEN LANTERN SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, 1,2-hexanediol and 1,2-pentanediol are expensive, the prices are about 300 yuan / Kg and 350 yuan / Kg respectively, the production cost is relatively high, and they are not suitable for large-scale industrial production
At the same time, the viscosity of 1,2-hexanediol and 1,2-pentanediol is relatively high, and the heat and mass transfer resistance is relatively large, which is not conducive to the industrial extraction of oat alkaloids
Moreover, 1,2-hexanediol and 1,2-pentanediol have relatively high boiling points (the boiling point of 1,2-hexanediol is 223°C, and the boiling point of 1,2-pentanediol is 206°C), which are not easily volatile and remain The 1,2-hexanediol and 1,2-pentanediol are easy to cause adverse reactions such as heat sensation and irritation on the skin

Method used

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  • Oat total alkaloid, anti-skin-allergy composition and preparation method of anti-skin-allergy composition
  • Oat total alkaloid, anti-skin-allergy composition and preparation method of anti-skin-allergy composition
  • Oat total alkaloid, anti-skin-allergy composition and preparation method of anti-skin-allergy composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0140] Example 1 A kind of anti-skin allergy composition

[0141] The composition of the anti-skin allergy composition described in this embodiment is: 12Kg of oat total alkaloids, 0.3Kg of bisabolol.

[0142]Wherein the oat total alkaloids were prepared according to the conditions of Experiment No. 12 in Research Example 1.

[0143] Stir and mix the above-mentioned oat total alkaloids and bisabolol evenly to obtain the product.

Embodiment 2

[0144] Example 2 An Oatmeal Allergy Lotion

[0145] Accurately weigh the following raw materials: 1 g of allantoin, 3 g of p-hydroxyacetophenone, 50 g of mineral oil, 123 g of the anti-skin allergy composition prepared in Example 1, 6 g of AVC, 3 g of panthenol, 5 g of 1,2-hexanediol, 0.1 g of disodium EDTA, 808.9 g of purified water.

[0146] Prepare as follows:

[0147] Add purified water, allantoin, p-hydroxyacetophenone, and AVC into the water phase pot, turn on and heat up to 80-85°C, keep stirring for 30 minutes. Add mineral oil into the oil phase pot, turn on and heat up to 80-85°C. Add the water phase material into the emulsification pot first, and then add the oil phase material into the emulsification pot. Turn on the homogenizer for 5 minutes, and after stirring for 10 minutes, start to cool down. Cool down to 45°C, add the anti-skin allergy composition, panthenol, 1,2-hexanediol, and disodium EDTA, and stir evenly. Cool down to 35°C, and filter with a 200-me...

Embodiment 3

[0148] Example 3 An oatmeal anti-allergic face cream

[0149] Accurately weigh the following raw materials: 1 g of allantoin, 4 g of p-hydroxyacetophenone, 100 g of mineral oil, 50 g of petrolatum, 123 g of the anti-skin allergy composition prepared in Example 1, 10 g of AVC, 3 g of panthenol, 1,2-hexane 5 g of diol, 0.1 g of disodium EDTA, and 703.9 g of purified water.

[0150] Prepare as follows:

[0151] Add purified water, allantoin, p-hydroxyacetophenone, and AVC into the water phase pot, turn on and heat up to 80-85°C, keep stirring for 30 minutes. Add mineral oil and petrolatum into the oil phase pot, turn on and heat up to 80-85°C, and stir until the oil phase materials are completely dissolved. Add the water phase material into the emulsification pot first, and then add the oil phase material into the emulsification pot. Turn on the homogenizer for 5 minutes, and after stirring for 10 minutes, start to cool down. Cool down to 45°C, add the anti-skin allergy com...

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Abstract

The invention provides an extraction method for oat total alkaloid. The method comprises the following operation steps that oat bran and C3-C4 saturated binary fatty alcohol are mixed according to thematerial-liquid mass ratio of the oat bran to the C3-C4 saturated binary fatty alcohol of 1:(10-25), subjected to heat preservation stirring at 55-70 DEG C for 3-6 hours and filtered when the mixtureis hot, and the oat total alkaloid is obtained. The C3-C4 saturated binary fatty alcohol is selected from one or more of 1,2-propylene glycol, 1,3-propylene glycol and 1,3-butanediol. The invention further provides application of the oat total alkaloid prepared through the extraction method in skin allergy resistance. The preparation method of the oat total alkaloid is low in cost, high in extraction efficiency, easy and convenient to implement and particularly suitable for industrial production.

Description

technical field [0001] The invention belongs to the fields of natural product chemistry and medicine, and in particular relates to a total oat alkaloid, an anti-skin allergy composition containing the total oat alkaloid and a preparation method thereof. Background technique [0002] From the outside to the inside, the skin can be divided into three parts: epidermis, dermis and subcutaneous tissue. The most important protective function in the epidermis is the stratum corneum, which is located in the outermost layer. Its main function is to protect the dermis and subcutaneous tissue, prevent the entry of pathogenic microorganisms from the outside, and prevent the evaporation and loss of water in the skin. The dermis contains a large number of immune cells, including mast cells, which are closely related to skin allergies. When the stratum corneum is damaged, exogenous allergens (such as pollen and dust) pass through the epidermis to reach the dermis, or ingested allergens (s...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/899A61K31/045A61P17/00A61P37/08A61K8/9794A61K8/34A61Q19/00
CPCA61K36/899A61K31/045A61P17/00A61P37/08A61K8/9794A61K8/342A61Q19/00A61K2236/33A61K2800/75A61K2300/00
Inventor 梅杰钱军张许昌邓攀攀李晓彪周丹贤
Owner SHENZHEN LANTERN SCI
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