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Method for detecting sildenafil in white spirit

A technology of sildenafil and Chinese and Western soil, applied in the field of detection of sildenafil in liquor, can solve the problems of limited development, huge instruments and high-cost, complex and time-consuming sample pretreatment process

Inactive Publication Date: 2019-11-19
SHANDONG IND TECH RES INST OF ZHEJIANG UNIV +1
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  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Although traditional methods for the determination of sildenafil have high sensitivity, complex and time-consuming sample pretreatment processes, huge instruments and high costs limit their development

Method used

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  • Method for detecting sildenafil in white spirit
  • Method for detecting sildenafil in white spirit
  • Method for detecting sildenafil in white spirit

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Embodiment Construction

[0026] The structures involved in the present invention or the technical terms used are further described below. These descriptions are only used as examples to illustrate how the present invention is implemented, and do not constitute any limitation to the present invention.

[0027] The method for detecting sildenafil in liquor comprises the following steps:

[0028] Step 1, carry out spectrum peak assignment to the Raman spectrum of sildenafil solid standard substance, obtain sildenafil Raman characteristic peak, obtain the SERS of 100mg / L sildenafil mixed with methanol and 100mg / L sildenafil at the same time SERS of nafil mixed with liquor. Among them, the parameters of Raman spectrum acquisition are set as: excitation wavelength 785nm, power 100mW, scanning range 200-3300cm -1 , optical resolution 2cm -1 , the integration time is 10s, and the average spectral value is obtained by integrating 3 times. The purpose of spectral peak assignment is to perform qualitative di...

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Abstract

The invention discloses a method for detecting sildenafil in white spirit. The method comprises the steps of (1) carrying out spectral peak attribution on a Raman spectrum of sildenafil and obtaininga Raman characteristic peak of the sildenafil; (2) weighing a sildenafil standard, dissolving the sildenafil standard into methanol to obtain a sildenafil standard solution of which the concentrationis 1,000mg / L and mixing the white spirit with the sildenafil standard solution to prepare multiple test solutions of different concentrations; (3) mixing the test solutions with active colloid OTR 202at the volume ratio of 1:5 and carrying out Raman spectrum acquisition; and (4) establishing a linear regression equation, namely y=27.004x+20.516, wherein y is the content of the sildenafil in the white spirit, the unit is mg / L and x is the intensity of the Raman characteristic peak at 1401cm<-1>. The sildenafil in the white spirit is detected on the basis of surface-enhanced Raman spectroscopy,so that the method is novel, fast and accurate, and can meet the requirements on analysis and detection of the sildenafil in the white spirit.

Description

technical field [0001] The invention relates to the detection field, more specifically, it relates to a method for detecting sildenafil in liquor. Background technique [0002] The following background art is provided to help the reader understand the present invention and is not to be admitted as prior art. [0003] Sildenafil (SD), one of the inhibitors of phosphodiesterase type 5 (PDE-5), is often added to health supplement products for the treatment of erectile dysfunction (ED) in men. Due to its side effects such as headache, indigestion, back pain, rhinitis and flu syndrome, the use of sildenafil must be strictly controlled under medical supervision. Several investigations have indicated that sildenafil is illegally adulterated in some dietary supplements, herbal remedies and alcoholic beverages. Limited by complex sample processing and extraction, traditional sildenafil determination methods mainly focus on high performance liquid chromatography (HPLC), ultraviolet ...

Claims

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Application Information

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IPC IPC(8): G01N21/65
CPCG01N21/658
Inventor 聂鹏程蔺磊瞿芳芳
Owner SHANDONG IND TECH RES INST OF ZHEJIANG UNIV
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