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Degradable polymer microsphere with surface concave pits and preparing method and application thereof

A technology of polymer microspheres and polymer solutions, applied in the field of medicine, can solve the problems of difficult to predict the degradation rate of the internal structure of microspheres, difficult to predict performance evolution, complex preparation process, etc., to achieve good application prospects and good biocompatibility Non-toxicity and degradability, the effect of simple process

Active Publication Date: 2019-11-15
GUANGDONG PROV MEDICAL INSTR INST
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Problems solved by technology

However, the microspheres prepared by the above-mentioned prior art generally have the following problems: 1) multi-component, and the performance evolution during application is difficult to predict; 2) porous microspheres are prepared instead of surface pit microspheres, and the internal structure of the microspheres changes It has an unpredictable impact on its degradation rate; 3) The preparation process is complex and difficult to industrialize

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  • Degradable polymer microsphere with surface concave pits and preparing method and application thereof

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preparation example Construction

[0030] Example 1 of the present invention is: a preparation method of degradable polymer microspheres with pits on the surface, comprising the following steps: weighing 3.0 g of poly 3-hydroxybutyrate-co-3-hydroxyvalerate and dissolving it in 10ml volatile organic solvent (chloroform); add poly-3-hydroxybutyrate-co-3-hydroxyvalerate solution to 700ml aqueous solution containing 1.5% gelatin, keep stirring at 600rpm at 45°C; after 45min Add 3.5g Freon; stop stirring after 10h of adding poly 3-hydroxybutyrate-co-3-hydroxyvalerate solution, wash with water and dry at 45°C for 24h to obtain poly 3-hydroxybutyrate-co-3-hydroxyvalerate with surface pits co-3-hydroxyvalerate microspheres.

[0031] Example 2 of the present invention is: a preparation method of degradable polymer microspheres with pits on the surface, comprising the following steps: dissolving 5.0 g of polytrimethylene carbonate in 10 ml of tetrahydrofuran; Add the ester solution to 1000ml of an aqueous solution conta...

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Abstract

The invention discloses a degradable polymer microsphere with surface concave pits and a preparing method and application thereof. The preparing method comprises the following steps of S1, dissolvinga degradable polymer into an organic solvent to prepare a degradable polymer solution; S2, adding the degradable polymer solution into an aqueous solution containing a surfactant, and after the materials are stirred for 15-45 minutes, adding a gas foaming agent; S3, continuing stirring the materials for 315-705 minutes, and then conducting washing and drying to obtain the degradable polymer microsphere with the surface concave pits. The prepared microsphere has good biocompatibility and degradability, is also provided with the surface concave pits suitable for cells to adhere to, and has a good application prospect in the field of tissue defect repairing and reconstruction.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a degradable polymer microsphere with pits on the surface and a preparation method and application thereof. Background technique [0002] Polymer microspheres usually refer to polymer aggregates with diameters ranging from nanometers to micrometers and spherical shapes. Polymer microspheres have attracted more and more scientists' interest due to their designability and multifunctionality. Among them, the spherical shape is divided into solid sphere and hollow sphere. Degradable biomicrospheres have very important applications in the medical field, some can be used as bone fillers, and some can be used as drug carriers, with great application prospects. Related research shows that compared with ordinary microspheres, microspheres with specific morphology have a larger surface area, and for tissue repair, in addition to being non-toxic to tissues and cells, it is also necessary...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/18A61L27/22A61L27/16A61L27/20A61L27/02A61L27/50A61L27/58
CPCA61L27/18A61L27/222A61L27/16A61L27/20A61L27/025A61L27/50A61L27/58C08L67/04C08L69/00C08L29/04C08L1/02
Inventor 许为康陈龙胜邹丽丽伊翔
Owner GUANGDONG PROV MEDICAL INSTR INST
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