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Application of combination of D-penicillamine and fluconazole in preparing antifungal products

A penicillamine and antifungal technology, applied in the field of combined antifungal drugs, can solve the problems of large economic investment, long time consumption of antibacterial drugs, increase in fungi, etc., and achieve the effects of reducing side effects, great clinical significance, and reducing dosage

Active Publication Date: 2019-11-15
MATERNAL & CHILD HEALTH CARE HOSPITAL OF SHANDONG PROVINCE SHANDONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the frequent use of fluconazole in clinical treatment, the drug resistance of fungi has gradually increased, which has brought great challenges to the clinical treatment of deep fungal infections.
Researching new antimicrobials takes a long time and requires a lot of economic investment, so drug combination has become one of the effective strategies to overcome fungal drug resistance

Method used

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  • Application of combination of D-penicillamine and fluconazole in preparing antifungal products
  • Application of combination of D-penicillamine and fluconazole in preparing antifungal products

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Embodiment 1

[0038] In order to enable those skilled in the art to understand the technical solutions of the present disclosure more clearly, the technical solutions of the present disclosure will be described in detail below in conjunction with specific examples and comparative examples. Embodiment 1D-penicillamine and fluconazole combined antifungal action determination

[0039] 1. Materials

[0040] 1.1 Drugs and reagents

[0041] D-penicillamine (D-penicillamine, PCA), Dalian Meilun Biotechnology Co., Ltd.;

[0042] Fluconazole (FLC), Dalian Meilun Biotechnology Co., Ltd.;

[0043] CHROMagar Candida Chromogenic Medium, Zhengzhou Bosai Biological Engineering Co., Ltd.;

[0044] TTC-Sa Paul medium, Qingdao Hi-tech Park Haibo Biotechnology Co., Ltd.;

[0045] Yeast paste, Beijing Aoboxing Biotechnology Co., Ltd.;

[0046] Peptone, Beijing Aoboxing Biotechnology Co., Ltd.;

[0047] Glucose, Sinopharm Chemical Reagent Co., Ltd.;

[0048] Agar powder, Beijing Dingguo Changsheng Biotec...

Embodiment 2

[0087] The effect of embodiment 2 drug combination on drug-resistant Candida albicans hyphae growth

[0088] 1. Materials

[0089] 1.1 Drugs and reagents

[0090] D-penicillamine (D-penicillamine, PCA), Dalian Meilun Biotechnology Co., Ltd.;

[0091] Fluconazole (FLC), Dalian Meilun Biotechnology Co., Ltd.;

[0092] CHROMagar Candida Chromogenic Medium, Zhengzhou Bosai Biological Engineering Co., Ltd.;

[0093] TTC-Sa Paul medium, Qingdao Hi-tech Park Haibo Biotechnology Co., Ltd.;

[0094] Yeast paste, Beijing Aoboxing Biotechnology Co., Ltd.;

[0095] Peptone, Beijing Aoboxing Biotechnology Co., Ltd.;

[0096] Glucose, Sinopharm Chemical Reagent Co., Ltd.;

[0097] Agar powder, Beijing Dingguo Changsheng Biotechnology Co., Ltd.;

[0098] PBS phosphate buffer, Beijing Dingguo Changsheng Biotechnology Co., Ltd.;

[0099]Sodium hydroxide, state-owned Shandong Shanxian Organic Chemical Factory, batch number 940420;

[0100] Potassium dihydrogen phosphate, Shanghai Xinba...

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Abstract

The invention belongs to the technical field of antifungal drug combination, and particularly relates to application of combination of D-penicillamine and fluconazole drug in preparing antifungal products. Candida albicans is an infectious fungus with great harm degree, and the clinical common antifungal drug variety is limited. Drug-resistant strains continue to appear with the progress of treatment. The invention provides a study on the application of the combination of the D-penicillamine and the fluconazole antifungal drug in the treatment of drug-resistant candida albicans. The study result shows that the D-penicillamine can obviously reduce the dosage of the fluconazole medicament, reduce the drug resistance probability of the strain and reduce the dosage of the medicament, thereby being beneficial to eliminating the toxic and side effects caused by accumulation of the medicament in vivo. In addition, the combination of the D-penicillamine and the fluconazole drug has selective inhibition effect on drug-resistant strains, and also provides research basis for overcoming the drug resistance of fungi.

Description

technical field [0001] The disclosure belongs to the technical field of combined antifungal drugs, and specifically relates to the application of D-penicillamine combined with triazole drugs in the preparation of products for inhibiting drug-resistant Candida albicans. Background technique [0002] The information disclosed in this Background section is only intended to increase the understanding of the general background of the disclosure, and is not necessarily to be taken as an acknowledgment or any form of suggestion that the information constitutes prior art that is already known to those skilled in the art. [0003] In recent years, the incidence of invasive fungal infection has been increasing among immunocompromised populations such as cancer patients undergoing organ transplantation, catheter intubation patients, and AIDS patients. Candida is an invasive fungus with a relatively high proportion of clinical isolates, and the infection caused by Candida albicans (CA) ...

Claims

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Application Information

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IPC IPC(8): A61K31/4196A61K31/198A61P31/10
CPCA61K31/4196A61K31/198A61P31/10A61K2300/00Y02A50/30
Inventor 郝丽娜李一曼李秀云高燕谭玉凤刘亚鲁
Owner MATERNAL & CHILD HEALTH CARE HOSPITAL OF SHANDONG PROVINCE SHANDONG UNIV
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