Method and system for screening cancer biomolecular markers based on network topology parameters

A technology of network topology and biomolecules, applied in the field of biological information extraction, can solve the problems of low specificity and low precision of HCC

Active Publication Date: 2021-09-24
SHANDONG UNIV
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Problems solved by technology

The above-mentioned biomarkers that have been discovered all have the disadvantages of low HCC specificity and low precision, so it is urgent to find new and effective biomarkers to assist relevant clinical tests and diagnoses

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  • Method and system for screening cancer biomolecular markers based on network topology parameters
  • Method and system for screening cancer biomolecular markers based on network topology parameters
  • Method and system for screening cancer biomolecular markers based on network topology parameters

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Embodiment Construction

[0028] It should be noted that the following detailed description is exemplary and intended to provide further explanation of the present invention. Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs.

[0029] It should be noted that the terminology used here is only for describing specific embodiments, and is not intended to limit exemplary embodiments according to the present invention. As used herein, unless the context clearly dictates otherwise, the singular is intended to include the plural, and it should also be understood that when the terms "comprising" and / or "comprising" are used in this specification, they mean There are features, steps, operations, means, components and / or combinations thereof.

[0030] In the case of no conflict, the embodiments and the features in the embodiments of the present invention can be combined with eac...

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Abstract

The invention discloses a method and system for screening cancer biomolecular markers based on network topology parameters. The method includes: acquiring human intergenic interaction network and gene chip expression data, and integrating the intergenic interaction based on the gene expression data. Network; construct the interaction network between genes in the disease state and the control state; calculate the network topology parameter difference gene between the disease state and the control state gene interaction network, and obtain the network topology parameter difference change network based on the network parameter difference gene; Mining the network modules of the topological parameter difference network; performing feature selection on the obtained difference network modules to obtain the genes that are distinguishable between normal and disease in each module; detecting the classification effect of the genes selected in each module on diseases, and screening according to the classification effect Differential network modules as biomolecular marker candidates. The present invention provides a new complex disease biomarker recognition method based on omics data, which is proved to have certain accuracy and effectiveness by experiments.

Description

technical field [0001] The invention belongs to the technical field of biological information extraction, and in particular relates to a method and system for screening cancer biomolecular markers based on network topology parameters. Background technique [0002] The statements in this section merely provide background information related to the present disclosure and do not necessarily constitute prior art. [0003] Cancer (malignant tumor) is a large class of diseases that threaten human life and health, and its morbidity and mortality are increasing year by year worldwide. According to data, in 2018, 18.1 million new cancer cases and 9.6 million cancer deaths are expected to occur, of which China is expected to have over 4.05 million new cancer cases and over 2.61 million cancer deaths, and an average of 10,000 people are diagnosed with cancer every day , the situation is very serious. [0004] Liver cancer (liver cancer), that is, malignant liver tumors, is the sixth ...

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G16B5/00G16B20/20G16B25/10G06K9/62
CPCG16B5/00G16B20/20G16B25/10G06F18/2411
Inventor 刘治平王艳秋
Owner SHANDONG UNIV
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