Method for synthesizing M acid

Abstract

The invention belongs to the field of chemical synthesis, and particularly relates to a method for synthesizing M acid. The method includes reacting 5-dinitro-2,4,6-trimethylbenzenesulfonic acid adopted as a raw material at a high temperature under high pressure with the presence of carbon monoxide gas by adopting water as a solvent, adopting selenium as a catalyst and adopting an alkali as a co-catalyst; performing stirring and filtration; adjusting pH with hydrochloric acid to precipitate a product; and performing suction filtration and recrystallization to obtain a target product. The moleratio of the 5-dinitro-2,4,6-trimethylbenzenesulfonic acid to the selenium is 100:2-10, the mole ratio of the 5-dinitro-2,4,6-trimethylbenzenesulfonic acid to the water is 1:111 to 1:667, and the moleratio of the 5-dinitro-2,4,6-trimethylbenzenesulfonic acid to the co-catalyst is 5:1 to 5:8. The alkali is an organic alkali or an inorganic alkali. The method adopts a high-pressure reaction in a one-pot reaction manner, and is low in equipment investment, simple and safe to operate, low in cost, capable of meeting requirements of green chemistry, economical, capable of phase transfer catalysis,and the like.

Description

technical field [0001] The invention belongs to the field of chemical synthesis, in particular to a method for synthesizing M acid. Background technique [0002] M acid, the chemical name is 3,5-diamino-2,4,6-trimethylbenzenesulfonic acid, referred to as M acid. [0003] As an important chemical raw material, dyes play an important role in life and production, among which the dyes of bromamine blue 3R and reactive brilliant blue K-3R are in great demand at home and abroad. And M acid is exactly the important intermediate of synthesizing these two kinds of dyes, and M acid is highly selectively generated under high-pressure selenium catalysis, makes the synthesis of dye intermediate M acid more green, and more meets the needs of modern industrial production. There are two traditional reduction methods for synthesizing M acid: (1) iron powder reduction method, and (2) catalytic hydrogenation reduction method. The above two methods have their own advantages and disadvantages....

AI Technical Summary

Problems solved by technology

But because there is a small amount of sulfur in the M acid nitro, the catalyst is easily deactivated during the catalytic hydrogenation process, which not only affects the reaction process but also increases the cost of the catalyst.

Therefore, the above two methods are limited to a certain extent in industrial production.

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