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Application of eight-jewel elixir in preparing drugs for preventing or treating diseases related with IL-6inflammatory factor storm

A technology of IL-6 and inflammatory factors, applied in the field of biomedicine

Active Publication Date: 2019-11-08
XIAMEN TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, there is no research showing the application of Babaodan in the prevention or treatment of diseases related to IL-6 inflammatory factor storm

Method used

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  • Application of eight-jewel elixir in preparing drugs for preventing or treating diseases related with IL-6inflammatory factor storm
  • Application of eight-jewel elixir in preparing drugs for preventing or treating diseases related with IL-6inflammatory factor storm
  • Application of eight-jewel elixir in preparing drugs for preventing or treating diseases related with IL-6inflammatory factor storm

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] Example 1: Inhibition of Babaodan on the expression and release of IL-6 inflammatory factors in the acute lung injury model caused by influenza virus PR8 secondary SA infection

[0033] experimental animals

[0034] SPF grade C57BL / 6 mice, female, 6-8 weeks old, weighing 16-21 g. Provided by the Animal Experiment Center of Zhejiang University, purchased from Shanghai Slack Experimental Animal Co., Ltd. Laboratory animal quality certificate: SCXK (Shanghai) 2007-0005. The experimental animals were raised in a clean-grade animal center of Zhejiang University, room temperature was 20-22°C, the light was 12 hours of light, 12 hours of darkness, and adequate standard feed and drinking water were given. The experimental operating procedures strictly followed the "Regulations on the Administration of Experimental Animals" of Zhejiang University.

[0035] Experimental Bacteria and Viruses

[0036] H1N1 influenza virus strain PR8 (Puerto-Rico / 8) and Staphylococcus aureus (SA...

Embodiment 2

[0060] Example 2: Study on the pharmacodynamic evaluation of Babaodan on the expression and release of IL-6 inflammatory factors based on the macrophage TLRs activation model

[0061] cell culture

[0062] Mouse mononuclear macrophage cell line Raw 264.7 (ATCC TIB-71), the culture medium is DMEM high-glucose medium containing 10% inactivated FBS, penicillin and streptomycin, and the culture conditions are 37°C, 5% CO 2 . Cells in the logarithmic growth phase were used for experiments.

[0063] Effect of Babaodan on the expression and release of IL-6 inflammatory factor induced by TLRs activation

[0064] See Table 2 below for the list of TLRs agonists and their working concentrations.

[0065] The experimental protocol is as follows: Raw 264.7 cells were treated with 1×10 5 / well seeded in a 12-well plate. After 24 hours, the culture medium containing Babaodan was changed. After 22 hours, the drug-containing culture medium was changed again, TLRs agonist was added after ...

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Abstract

The invention provides application of eight-jewel elixir in preparing drugs for preventing or treating diseases related with IL-6inflammatory factor storm.

Description

technical field [0001] The invention belongs to the field of biomedicine, and more specifically, the invention relates to the use of Babaodan in the preparation of medicines for preventing or treating diseases related to IL-6 inflammatory factor storm. Background technique [0002] Interleukin IL-6 is rapidly induced and expressed in large quantities in the setting of infection, autoimmunity or cancer. IL-6 has also been linked to some psychiatric disorders. IL-6 was significantly elevated in patients with major depressive disorder. In tumor immunotherapy, the storm of inflammatory cytokines caused by IL-6 is a common side effect. [0003] Babao Dan is derived from ancient Chinese medicine prescriptions, and has the effects of clearing away dampness and heat, promoting blood circulation and detoxification, removing jaundice and relieving pain. In clinical practice, Babaodan has a good therapeutic effect on infectious diseases such as viral infections and acute urinary sys...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K35/618A61P31/00A61P37/02A61P35/00A61P25/00A61K31/045A61K33/28A61K33/30A61K35/02A61K35/10A61K35/36A61K35/413
CPCA61K31/045A61K33/28A61K33/30A61K35/02A61K35/10A61K35/36A61K35/413A61K35/618A61P25/00A61P31/00A61P35/00A61P37/02A61K2300/00
Inventor 关斌钱景赖志成王毅程翼宇南淑华詹志学墙世发陈西翌何敏婉郑珊珊许玉珍陈晓琳阳丽华曾智发
Owner XIAMEN TRADITIONAL CHINESE MEDICINE
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