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Halloysite composite hydrogel for promoting bone defect repairing, and preparation method and application thereof

A composite hydrogel and bone defect technology, applied in medical science, prosthesis, tissue regeneration, etc., to achieve good mechanical properties, promote new bone formation, and promote bone defect repair

Active Publication Date: 2019-11-05
HOSPITAL OF STOMATOLOGY SUN YAT SEN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there are few studies on implanting osteoblasts or stem cells directly as cell carriers into bone defects.

Method used

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  • Halloysite composite hydrogel for promoting bone defect repairing, and preparation method and application thereof
  • Halloysite composite hydrogel for promoting bone defect repairing, and preparation method and application thereof
  • Halloysite composite hydrogel for promoting bone defect repairing, and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0052] The preparation of embodiment 1 halloysite composite hydrogel

[0053] 1, a kind of halloysite composite hydrogel that promotes bone defect repair, its preparation method comprises the following steps:

[0054] (1) Preparation of pre-polymerization solution: After gelatin is modified by methacrylate, it is dissolved in pure water to prepare a methacrylate gelatin solution with a concentration of 15%, and 0.1% (w / v) of DMSO is added. The photoinitiator I2959, and then add a concentration of 5% halloysite nanotubes, and mix the three to obtain a pre-polymerization solution;

[0055] Among them, the method for methacrylated gelatin is as follows: the super gelatin derived from pigskin is dissolved in PBS buffer solution in a water bath at 50°C, and prepared into a solution with a concentration of 10% (w / v), at 0.5mL / min Slowly add methacrylic anhydride dropwise at a rate of 5:1 (w / v) to gelatin, stir and react in a water bath at 50°C for 6 hours, then add 4 times the amou...

Embodiment 2

[0057] The preparation of embodiment 2 halloysite composite hydrogel

[0058] A reaction similar to that in Example 1 was performed except that the concentration of halloysite nanotubes in Example 1 was changed to 7%. Through this reaction, a halloysite composite hydrogel with a dense porous three-dimensional network structure, which can be used as a cell scaffold material, can accelerate the proliferation and differentiation of bone cells and periodontal cells, and promote the regeneration of bone tissue and periodontal tissue is obtained.

Embodiment 3

[0059] The preparation of embodiment 3 halloysite composite hydrogel

[0060] A reaction similar to that in Example 1 was performed except that the concentration of halloysite nanotubes in Example 1 was changed to 3%. Through this reaction, a halloysite composite hydrogel with a dense porous three-dimensional network structure, which can be used as a cell scaffold material, can accelerate the proliferation and differentiation of bone cells and periodontal cells, and promote the regeneration of bone tissue and periodontal tissue is obtained.

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Abstract

The invention discloses a halloysite composite hydrogel for promoting bone defect repairing, and a preparation method and an application thereof. The halloysite composite hydrogel is obtained by photocrosslinking of a halloysite-doped gelatin solution under the action of a photoinitiator, and the halloysite composite hydrogel has a dense porous three-dimensional network structure; halloysite and adouble-bonded gelatin are used to successfully synthesize the composite hydrogel for promoting bone defect repairing; and the composite hydrogel can be used as an excellent scaffold material for bonetissue engineering, has good mechanical properties, mechanical properties and biological properties, can support the growth and osteogenic differentiation of bone cells, can obviously promote the formation of new bones and the repairing of bone defects, can be used for the effective treatment of diseases such as periodontal tissues or bone tissue defects, and has good clinical application prospects in fields of bioengineering and biomedical science.

Description

technical field [0001] The invention belongs to the technical field of bioengineering materials. More specifically, it relates to a halloysite composite hydrogel for promoting bone defect repair and its preparation method and application. Background technique [0002] Due to certain factors such as trauma, infection, tumor, etc., the bone loses some bone quality, forming a large gap, which is called bone defect. The clinical incidence of bone defect is relatively high, and its treatment is an important technical issue in orthopedics. Every year, tens of millions of patients suffer from bone defects worldwide due to severe trauma, fracture combined with infection, improper treatment after fracture, bone tumor or other complications. In my country, with the advent of an aging society, the incidence of bone diseases is on the rise, which directly leads to an increase in medical expenses and a decline in production efficiency and quality of life. Although in recent years more...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08J3/24C08J3/075A61L27/58A61L27/50A61L27/52A61L27/56A61L27/22A61L27/02
CPCA61L27/025A61L27/222A61L27/50A61L27/52A61L27/56A61L27/58C08J3/075C08J3/24C08K3/346C08J2389/00A61L2430/02Y02P10/25
Inventor 王彦吴钧顾志鹏欧乾民黄钶晴解韫亦
Owner HOSPITAL OF STOMATOLOGY SUN YAT SEN UNIV
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