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Extraction process of throat clearing and nourishing preparation optimized by means of orthogonal test

An orthogonal experiment, throat-clearing and throat-clearing technology, applied in solid solvent extraction, measuring devices, instruments, etc., can solve problems such as slow effect and unable to relieve throat discomfort in time

Active Publication Date: 2019-10-25
四川万医芝家科技有限公司
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AI Technical Summary

Problems solved by technology

[0007] However, in practical application, it is often found that the prescription is slow to take effect and cannot relieve the discomfort of the throat in time for patients with acute pharyngitis. It is urgent to optimize and improve the formula to reduce the patient's medication course and pain.

Method used

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  • Extraction process of throat clearing and nourishing preparation optimized by means of orthogonal test
  • Extraction process of throat clearing and nourishing preparation optimized by means of orthogonal test
  • Extraction process of throat clearing and nourishing preparation optimized by means of orthogonal test

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Embodiment Construction

[0038] The following is further described in detail through specific implementation methods:

[0039] Orthogonal test was used to optimize the extraction process of throat-clearing and throat-relieving preparations. The content of gallic acid, scopoletin, basartone, nuciferine in the extract and the comprehensive weighted score of the cream yield were used as evaluation indicators. L 9 (3 4 ) orthogonal experiment, with ethanol concentration, solid-liquid ratio, extraction times, and extraction time as the investigation factors, optimize the extraction process of throat-clearing and moistening-throat preparation and carry out process verification.

[0040] The specific implementation process is as follows: wherein the purity of gallic acid reference substance, scopoletin reference substance, basartene reference substance and nuciferine reference substance is 99.04%, 99.00%, 98.00%, and 98.91%, respectively. Green fruit medicinal material and lotus leaf medicinal material were...

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PUM

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Abstract

The invention discloses optimization of an extraction process of the throat clearing and nourishing preparation by means of an orthogonal test. The extraction process regards comprehensive weighted score of gallic acid, scopoletin, scoparone, nuciferine content and an extract yield rate in the extract as an evaluation index, adopts an L9 (3<4>) orthogonal test, takes ethanol concentration, a ratioof solid to liquid, a number of extraction times and extraction time as investigation factors, optimizes the extraction process of the throat clearing and nourishing preparation, and carries out process verification. The extraction process of the throat clearing and nourishing preparation optimized by means of the orthogonal test has good feasibility and repeatability, and provides a certain basis for the subsequent production process research.

Description

technical field [0001] The invention belongs to the field of preparation manufacturing, and in particular relates to an extraction process for optimizing throat-clearing and throat-moistening preparation through orthogonal experiments. Background technique [0002] For pharyngitis diseases, pharyngitis is divided into 2 categories. Acute inflammation of pharyngeal mucosa and submucosal tissue is classified as acute pharyngitis. The diffuse chronic inflammation of the pharyngeal mucosa, submucosa and lymphoid tissue is classified as chronic pharyngitis. Chronic pharyngitis has the characteristics of stubborn symptoms and difficult to cure thoroughly. [0003] In recent years, investigations and studies on the treatment of pharyngitis have shown that no matter the method of traditional Chinese medicine, Western medicine or the method of combining traditional Chinese and Western medicine, all have certain curative effects on the treatment of pharyngitis. But Western medicine...

Claims

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Application Information

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IPC IPC(8): G01N30/02G01N30/14B01D11/02
CPCG01N30/02G01N30/14B01D11/02G01N2030/047G01N2030/146
Inventor 张丹陈斯玮雷辉刘红罗禹傅秀娟
Owner 四川万医芝家科技有限公司
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