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Use of alkaloid as inflammatory cancer translation blocking and tumor preventing medicine

A drug and inflammatory cancer technology, which is applied in the application field of lotus leaf alkaloid in the preparation of drugs for blocking inflammatory cancer transformation and preventing tumors, and can solve problems such as unreported therapeutic effect of intestinal cancer.

Active Publication Date: 2015-04-15
TSINGHUA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Nuciferine has also been found to have anti-tumor effects such as inhibiting lung cancer, liver cancer and gastric cancer (Xu Xinyi. Graduation Thesis of Southwest Jiaotong University, 2006; Lu Lili et al. China Pharmacovigilance, 2013. Tian Xu et al. Chinese Medicine Guide, 2010; Liu Yanjuan et al. Chinese herbal medicine, 2012), but its therapeutic effect on intestinal cancer caused by inflammation has not been reported

Method used

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  • Use of alkaloid as inflammatory cancer translation blocking and tumor preventing medicine
  • Use of alkaloid as inflammatory cancer translation blocking and tumor preventing medicine
  • Use of alkaloid as inflammatory cancer translation blocking and tumor preventing medicine

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] Example 1 The effect of nuciferine on preventing tumors (preventing and / or blocking inflammatory cancer transformation)

Embodiment approach

[0038] Implementation: BALB / C mice were divided into 3 groups: normal control group, model group and nuciferine intervention group, with 9 mice in each group. The mice in the model group and the nuciferine intervention group were injected intraperitoneally with the gene mutation agent azoxymethane (AOM, 20 mg / Kg), once in each stage. One week after AOM administration, 3% dextran sulfate sodium (DSS) was used to replace the normal drinking water, and the mice drank continuously for 7 days; after that, the normal drinking water was replaced, and the mice drank continuously for 14 days. It takes 28 days from AOM injection, drinking DSS water to switching to normal water, and this cycle is repeated 3 times. Mice in the normal control group were fed and drank normally without any treatment. The model group did not receive any drug treatment. Nuciferine was purchased from Shaanxi Xisheng Biotechnology Co., Ltd., with a specification of 100 mg and a purity of not less than 98%. Nu...

Embodiment 2

[0046] Embodiment 2 Nuciferine is to the median lethal dose of mice

[0047] Experimental plan: This experiment was divided into two batches. The first batch of BALB / C mice were divided into 5 groups: 0.1g / Kg, 0.5g / Kg, 1g / Kg, 1.5g / Kg and 2g / Kg, 10 mice in each group , half male and half male. The second batch of mice was divided into 3 groups: 1.6g / Kg, 1.8g / Kg and 2g / Kg, 10 in each group, half male and half male.

[0048] Experimental results: The median lethal dose of nuciferine to BALB / C mice is between 1.6-1.8g / kg.

[0049] The above in vivo experimental results show that nuciferine can effectively prevent and / or block the transformation of gastrointestinal inflammation, especially effectively block the transformation of severe ulcerative enteritis to intestinal cancer; It works at less than one percent of the half-lethal dose. It can be seen that, in today's situation where the incidence of tumors remains high, nuciferine can be used as an effective drug for the prevent...

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Abstract

The invention provides a use of nuciferine in the preparation of inflammatory cancer translation preventing and / or blocking medicines, that is, a use of a compound represented by a formula shown in the specification or pharmaceutically acceptable salts, solvates, polycrystals, enantiomers or a racemic mixture thereof in the preparation of tumor preventing and / or blocking medicines. In vivo experiments show that the above nuciferine compounds can block the inflammatory cancer translation of the digestive tract, have a digestive tract tumor prevention function, and can especially prevent the translation of moderate and severe enteritis to intestine cancer and prevent the intestine cancer. The above compounds are from traditional Chinese medicines, have small toxic side effects, and can be used to prepare medicines for preventing and / or blocking the inflammatory cancer translation of digestive tract organs especially the intestine.

Description

technical field [0001] The invention belongs to the field of tumor prevention medicines, and in particular relates to the application of nuciferine in the preparation of medicines for blocking inflammatory cancer transformation and preventing tumors. Background technique [0002] According to statistics, about 15% of cancers are triggered by chronic inflammation, especially ulcerative inflammation. Epidemiological surveys and scientific research results in recent years have confirmed that various chronic inflammations are related to the occurrence of tumors. For example, the incidence of gastrointestinal tumors remains high and is closely related to various inflammations, including esophagitis and Barrett’s esophagus and esophageal cancer, Helicobacter pylori infection and gastric cancer, inflammatory bowel disease and colorectal cancer, hepatitis and Hepatocellular carcinoma occurs, chronic pancreatitis occurs with pancreatic cancer, etc. The occurrence of digestive system...

Claims

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Application Information

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IPC IPC(8): A61K31/473A61P35/00
CPCA61K31/473
Inventor 李梢李慧颖
Owner TSINGHUA UNIV
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