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A light-to-heat conversion material and its preparation method

A technology of photothermal and metal ions, which is applied in the direction of wave energy or particle radiation treatment materials, pharmaceutical formulations, medical preparations containing active ingredients, etc., can solve the problems of poor cell compatibility, low near-infrared photothermal efficiency, and high cost. The preparation method is simple, the effect of accelerating cell proliferation and promoting tissue regeneration is achieved

Active Publication Date: 2021-12-07
SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, these near-infrared photosensitizers still have some problems, such as high cost, low near-infrared photothermal efficiency, poor cell compatibility, etc.

Method used

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  • A light-to-heat conversion material and its preparation method
  • A light-to-heat conversion material and its preparation method
  • A light-to-heat conversion material and its preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] A. Dissolve chitosan and silk fibroin in water to form a 30mg / mL mixture of chitosan / silk fibroin (CS / SF) (the mass ratio of chitosan / silk fibroin is 2:1) .

[0040] B. Disperse TA evenly in the chitosan / silk fibroin mixture obtained in step A to make the concentration 0.3mg / mL, and then add Fe dropwise to the mixture 3+ solution and make the concentration of iron ions in the mixed solution 0.15mg / mL.

[0041]C. Put the mixed solution prepared in step B into a mold, transfer it to a low-temperature environment to condense it into ice, and finally dry it by freeze-drying technology to form an antibacterial skin dressing with near-infrared light and heat. The morphology of the prepared dressing was characterized, and the results were as follows: figure 1 As shown, it can be seen that the resulting dressing has a rich porous structure. CSTFe(1.5) refers to the scaffold structure composed of chitosan, silk protein, tannic acid and iron ions, in which TA, Fe 3+ The conte...

Embodiment 2

[0052] A. Dissolve hyaluronic acid and collagen in water to prepare a 30 mg / mL hyaluronic acid / collagen mixture (the mass ratio of hyaluronic acid / collagen is 1:1).

[0053] B. Evenly disperse TA into the hyaluronic acid / collagen mixture prepared in step A to make the concentration 0.2mg / mL, and then add V to the mixture dropwise. 3+ solution and make the concentration of vanadium ions in the mixed solution 0.1mg / mL.

[0054] C. Put the mixed solution prepared in step B into a mold, transfer it to a low-temperature environment to condense it into ice, and finally dry it by freeze-drying technology to form an antibacterial skin dressing with near-infrared light and heat.

Embodiment 3

[0056] A. Sodium alginate and albumin were dissolved in water to form a 40 mg / mL sodium alginate / albumin mixture (the mass ratio of sodium alginate / albumin was 3:1).

[0057] B. Evenly disperse TA into the sodium alginate / albumin mixture prepared in step A to make the concentration 1mg / mL, and then add Fe dropwise to the mixture 3+ And the concentration of iron ions in the mixed solution was 0.5 mg / mL.

[0058] C. Put the mixed solution prepared in step B into a mold, transfer it to a low-temperature environment to condense it into ice, and finally dry it by freeze-drying technology to form an antibacterial skin dressing with near-infrared light and heat.

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PUM

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Abstract

The invention provides NIR light-to-heat conversion materials based on tannic acid / metal ion complexes and a preparation method thereof, mainly comprising TA with better biocompatibility, metal ions (Fe 3+ 、Ru 3+ , V 3+ ) added to medical materials, using TA, metal ions (Fe 3+ 、Ru 3+ , V 3+ ) The NIR light-to-heat conversion of the complex formed makes the material produce a higher thermal effect under the stimulation of NIR, so as to achieve the purpose of antibacterial. The material has excellent liquid absorption ability when used as a photothermal antibacterial and hemostatic skin dressing, and TA / metal ions can significantly improve the cell / tissue affinity of the material, which has broad application prospects in the medical field.

Description

technical field [0001] The invention belongs to the technical field of biological materials, and in particular relates to a photothermal conversion and antibacterial material. [0002] technical background [0003] Natural polymer-based skin dressings (films, cryogels, and hydrogels, etc.) have been widely used in wound healing due to their excellent biocompatibility and biodegradability. However, most natural polymer dressings do not have antibacterial activity, and it is difficult to avoid microbial infection during wound healing. At present, adding antibacterial agents (antibiotics, metal ions, and quaternary ammonium salts) is a common means to improve the antibacterial activity of wound dressings. However, the widespread use of antibiotics may lead to the emergence of bacterial resistance, and the long-term cytotoxicity of the use of metal ions and quaternary ammonium salts will greatly reduce the rate of wound healing. [0004] In recent years, near-infrared (NIR) pho...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L15/18A61L15/20A61L15/28A61L15/32A61L15/42A61L15/44A61L15/46A61L15/62A61L24/00A61L24/02A61L24/08A61L24/10A61K41/00A61P31/04A61P35/00
CPCA61K41/0052A61L15/18A61L15/20A61L15/28A61L15/32A61L15/425A61L15/44A61L15/46A61L15/62A61L24/0015A61L24/0036A61L24/0042A61L24/02A61L24/08A61L24/108A61L2300/404A61L2300/416A61L2400/04A61P31/04A61P35/00C08L5/08C08L89/00
Inventor 于云龙张仕勇李鹏飞
Owner SICHUAN UNIV
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