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Preparing method of calcium nutrient supplement

A technology of enhancer and calcium nutrition, which is applied in the field of preparation of calcium nutrition enhancer, can solve the problem of not being used by the body, and achieve the effect of promoting anabolism and simple operation

Active Publication Date: 2019-10-22
NANTONG UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the existing preparation process only considers how to increase the concentration of blood calcium through the absorption of calcium, but for the body, it may induce a new compensatory mechanism due to the increase of blood calcium concentration, that is, blood calcium Excreted by metabolism instead of being used by the body

Method used

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  • Preparing method of calcium nutrient supplement
  • Preparing method of calcium nutrient supplement
  • Preparing method of calcium nutrient supplement

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Step 1: Dissolve 250g of skimmed milk powder in deionized water, set the volume to 1000mL, adjust the pH value of the skimmed milk to 4.6 with 0.5mol / L hydrochloric acid solution, centrifuge at 3500r / min for 8min, discard the supernatant, Add 2 times the volume of deionized water to wash, centrifuge at 3500r / min for 8min, discard the supernatant, and obtain a casein precipitate;

[0030] Step 2: Take 20g of casein precipitate, dilute to 100mL with deionized water to obtain a casein solution, then add 0.05g of trypsin with an activity unit of 250000U / g, place it in a water bath at 58°C, and use 0.5mol / L of sodium hydroxide solution to adjust the pH value to 7.4, heat-preserve the enzymolysis at 58°C for 2.5 hours, then treat it in a boiling water bath for 15 minutes to inactivate the enzyme, and obtain the enzymolysis solution;

[0031] Step 3: Use 0.5 mol / L hydrochloric acid solution to adjust the pH value of the enzymatic hydrolyzate to 4.6, centrifuge at 5000 r / min f...

Embodiment 2

[0034] Step 1: Dissolve 200g of skimmed milk powder in deionized water, set the volume to 1000mL, adjust the pH value of the skimmed milk to 4.6 with 0.5mol / L hydrochloric acid solution, centrifuge at 3500r / min for 8min, discard the supernatant, Add 2 times the volume of deionized water to wash, centrifuge at 3500r / min for 8min, discard the supernatant, and obtain a casein precipitate;

[0035] Step 2: Take 19g of casein precipitate, dilute to 100mL with deionized water to obtain a casein solution, then add 0.05g of trypsin with an activity unit of 250000U / g, place it in a water bath at 58°C, and use 0.5mol / L of sodium hydroxide solution to adjust the pH value to 7.4, heat-preserve the enzymolysis at 58°C for 2.5 hours, then treat it in a boiling water bath for 15 minutes to inactivate the enzyme, and obtain the enzymolysis solution;

[0036] Step 3: Use 0.5 mol / L hydrochloric acid solution to adjust the pH value of the enzymatic hydrolyzate to 4.6, centrifuge at 5000 r / min f...

Embodiment 3

[0039]Step 1: Dissolve 250g of skimmed milk powder in deionized water, set the volume to 1000mL, adjust the pH value of the skimmed milk to 4.6 with 0.5mol / L hydrochloric acid solution, centrifuge at 3500r / min for 8min, discard the supernatant, Add 2 times the volume of deionized water to wash, centrifuge at 3500r / min for 8min, discard the supernatant, and obtain a casein precipitate;

[0040] Step 2: Take 21g of casein precipitate, dilute to 100mL with deionized water to obtain a casein solution, then add 0.05g of trypsin with an activity unit of 250000U / g, place it in a water bath at 60°C, and use 0.5mol / L of sodium hydroxide solution to adjust the pH value to 7.4, heat-preserve the enzymolysis at 60°C for 2.5 hours, then treat it in a boiling water bath for 15 minutes to inactivate the enzyme, and obtain the enzymolysis solution;

[0041] Step 3: Use 0.5 mol / L hydrochloric acid solution to adjust the pH value of the enzymatic hydrolyzate to 4.6, centrifuge at 5000 r / min fo...

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Abstract

The invention discloses a preparing method of a calcium nutrient supplement, and belongs to the field of biochemical engineering and food additives. The method includes the steps of hydrolyzing caseinas the raw material through trypsin to obtain casein phosphoeptide, making the casein phosphoeptide react with octacosanol and calcium phosphate under the effect of acid phosphatase, and conducting phosphate esterification to form the calcium nutrient supplement (casein phosphoeptide-octacosanol ester-calcium phosphate CPP-OOL-ACP). The prepared calcium nutrient supplement (CPP-OOL-ACP) has the calcium content of 0.7% or above and the casein phosphoeptide and calcium chelating rate of 96%, is solid-state light yellow powder at normal temperature, is odorless, can be dissolved in water, and can effectively promote the calcium absorption and calcium deposition in bones, improve the bone density and increase the bone strength.

Description

technical field [0001] The invention relates to the fields of biochemical industry and food additives, in particular to a preparation method of a calcium nutrition enhancer. Background technique [0002] It is internationally recognized as the most economical and effective method to solve micronutrient malnutrition problems such as calcium through food fortification. There are more than 20 kinds of calcium supplements approved for use in the world (WHO / FAO). In my country ("Hygienic Standards for the Use of Food Nutrition Fortifiers" (GB14880)) the varieties of calcium nutrition fortifiers approved for use include calcium carbonate and calcium gluconate. , calcium citrate, calcium lactate, L-calcium lactate, calcium hydrogen phosphate, L-calcium threonate, calcium glycinate, calcium aspartate, calcium citrate malate, calcium acetate, calcium chloride, tricalcium phosphate, Vitamin E calcium succinate, calcium glycerophosphate, calcium oxide, calcium sulfate, bone powder, etc....

Claims

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Application Information

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IPC IPC(8): A23L33/165A23L33/18
CPCA23L33/165A23L33/18A23V2002/00A23V2250/1578A23V2250/55
Inventor 汤佳鹏葛彦朱俐
Owner NANTONG UNIVERSITY
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