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Synthetic method of improved micron-scale polystyrene microspheres

A technology of polystyrene microspheres and synthesis methods, applied in the field of biomedical engineering, to achieve the effects of stable synthesis process, high reproducibility, and high monodispersity

Pending Publication Date: 2019-10-18
NANJING NANOEAST BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The purpose of the present invention is to solve the problems in the synthesis of existing micron-sized polystyrene microspheres. On the basis of the existing dispersion polymerization, a costabilizer is added to improve the monodispersity of micron-sized polystyrene microspheres. properties and stability, and one-step synthesis of micron-sized polystyrene microspheres

Method used

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  • Synthetic method of improved micron-scale polystyrene microspheres
  • Synthetic method of improved micron-scale polystyrene microspheres
  • Synthetic method of improved micron-scale polystyrene microspheres

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Embodiment 1: change the consumption of monomer

[0019] The synthesis method in this example is as described in the description, the amount of monomers is changed, and other synthesis conditions remain unchanged. The specific composition is shown in Table 1.

[0020] Table 1 Composition of reaction system under different monomer dosage

[0021]

[0022] figure 1 is the corresponding product SEM.

[0023] figure 1 The SEM images in the middle show that the PS microspheres prepared when the monomer dosage is 5mL, 10mL, 15mL and 20mL all have good sphericity, and the monodispersity of the microspheres is good. However, with the increase of the amount of monomer, the average particle size of the microspheres also increases, and the particle size distribution gradually widens.

Embodiment 2

[0024] Embodiment 2: change the consumption of stabilizer

[0025] The synthesis method in this example is as described in the description, the amount of the stabilizer PVP is changed, and other conditions remain unchanged. The specific composition is shown in Table 2.

[0026] Table 2 Composition of the reaction system at different stabilizer concentrations

[0027]

[0028] figure 2 It is the scanning electron microscope picture of the product corresponding to different stabilizers. It can be seen from the figure that the particles of the microspheres are uniform and the monodispersity is good. With the increase of stabilizer dosage, the average particle size of microspheres decreases.

Embodiment 3

[0029] Embodiment 3: change the consumption of initiator

[0030] The synthesis method in this example is as described in the description, the amount of the initiator AIBN is changed, and other conditions remain unchanged. The specific composition is shown in Table 3.

[0031] Table 3 Composition of reaction system under different initiator concentrations

[0032]

[0033] image 3 is the SEM image of PS microspheres prepared under different amounts of initiators. Such as image 3 As shown, the microsphere particles are uniform and the surface is smooth. The average particle size of the microspheres increases with the increase of the initiator dose.

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Abstract

The invention discloses a synthetic method of improved micron-scale polystyrene microspheres. The method is characterized by comprising the following steps: in a three-neck round-bottom flask, dissolving a certain amount of a stabilizer polyvinyl pyrrolidone (PVP) and a co-stabilizer citric acid into a mixed solvent of ethanol and water, and then carrying out stirring at a speed of 150 rpm for 15minutes under protection of N2; and then weighing a certain amount of an initiator azodiisobutyronitrile (AIBN), dissolving the AIBN in styrene (St) monomers, carrying out heating to 55-80 DEG C in awater bath, and carrying out reacting for 12 hours to prepare the micron-scale polystyrene microspheres. The purpose of the invention is to solve problems in an existing micron-scale polystyrene microsphere synthesis method, and on the basis of existing dispersion polymerization, the co-stabilizer is added, so that monodispersity and stability of the micron-scale polystyrene microsphere synthesisare improved, and one-step synthesis of the micron-scale polystyrene microspheres is realized.

Description

technical field [0001] The invention belongs to the field of biomedical engineering and relates to a synthesis method of polystyrene microspheres, in particular to an improved synthesis method of micron-sized polystyrene microspheres. Background technique [0002] Monodisperse microspheres have a wide range of applications in the fields of materials, chemical engineering, and biomedicine. The size of monodisperse microspheres is closely related to its application field. Among them, micron-sized polystyrene microspheres have broad application prospects in the fields of biomedicine, analytical chemistry, colloid science, supercapacitor electrode materials, and chromatographic separation due to their strong surface adsorption and large aggregation. Therefore, the preparation of micron-sized PS microspheres with uniform particle size distribution, controllable particle morphology and surface characteristics has become a research hotspot in the field of polymer microspheres. At...

Claims

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Application Information

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IPC IPC(8): C08F112/08C08F2/12B01J13/14
CPCC08F112/08B01J13/14C08F2/12
Inventor 韩国志张宇王建国
Owner NANJING NANOEAST BIOTECH
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