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Microsphere-containing gel for injection and preparation method thereof

A technology for injection and gel, which is applied in the field of medical and aesthetic gel, which can solve the problems of poor fluidity of injection gel, and achieve the effects of avoiding uneven filling, excellent fluidity, and avoiding aggregation

Inactive Publication Date: 2019-10-15
YIPURUN SHANGHAI BIOTECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] In order to solve the problem of poor fluidity of the existing gel for injection existing in the above-mentioned prior art, the present invention aims to provide a gel for injection containing microspheres and a preparation method thereof

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Weigh 2g of hyaluronic acid, add it to 200ml of 0.9% sodium chloride physiological buffer solution to fully swell and balance, and obtain hyaluronic acid gel; weigh the molecular weight of 80,000-150,000 and the average particle size of 10-50um Mix 1.3g of PLA microspheres into hyaluronic acid gel, stir the mixture at 800r / min for 10min, and vacuumize for 24h to obtain hyaluronic acid gel containing microspheres; sterilize by high pressure steam at 110°C for 30min, Filled in disposable syringes.

Embodiment 2

[0026] Weigh 6g of hyaluronic acid, add it to 200ml of 1.1% sodium chloride physiological buffer to fully swell and balance, and obtain hyaluronic acid gel; weigh the molecular weight of 120,000-200,000 and the average particle size of 10-80um 1.3g of PLA microspheres and 1.3g of PCL microspheres with a molecular weight of 100,000-220,000 and an average particle size of 20-90um were mixed into the hyaluronic acid gel, and the mixture was stirred at 800r / min for 10min, pumped Vacuum for 24 hours to obtain a hyaluronic acid gel containing microspheres; sterilize with high pressure steam at 110° C. for 30 minutes, and fill it into a disposable syringe.

Embodiment 3

[0028] Weigh 12g of hyaluronic acid and add it to 200ml of 0.9% sodium chloride physiological buffer to fully swell and balance to obtain hyaluronic acid gel; weigh the molecular weight of 250,000-500,000 and the average particle size of 50-160um 3.6g of PLGA microspheres and 8.4g of PLA microspheres with a molecular weight of 300,000-600,000 and an average particle size of 80-180um were mixed into the hyaluronic acid gel, and the mixture was stirred at 1200r / min for 30min, pumped Vacuum for 24 hours to obtain a hyaluronic acid gel containing microspheres; sterilize with high pressure steam at 110° C. for 30 minutes, and fill it into a disposable syringe.

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Abstract

The invention relates to a microsphere-containing gel for injection. The gel comprises a carrier and degradable polyester microspheres dispersed in the carrier and used for carrying out filling and supporting functions, wherein the carrier is prepared from high polymer material particles and a physiological buffer solution. The invention also relates to a preparation method of the microsphere-containing gel for injection. The method comprises the following steps: S1, preparing the carrier by using the high polymer material particles and the physiological buffer solution; and S2, uniformly dispersing the degradable polyester microspheres in the carrier to form the microsphere-containing gel for injection. The microsphere-containing gel for injection provides a short-term filling and supporting function through the high polymer material particles, and provides a long-term filling and supporting function through the degradable polyester microspheres. In addition, the degradable polyestermicrospheres are uniformly dispersed in the carrier, so that the problems of uneven filling caused by local injection can be solved.

Description

technical field [0001] The invention relates to a gel for medical aesthetics, in particular to a gel for injection containing microspheres and a preparation method thereof. Background technique [0002] At present, injectable gels are widely used in cosmetic or medical treatment, especially to realize minimally invasive treatment at the injection site or to play the role of cosmetic filling. Compared with animal-derived materials, gel for injection is an artificial chemically synthesized polymer material, which can effectively reduce the risk of disease infection and improve the stability of the material, and has a wide range of applications. [0003] However, the flow properties of the existing gels for injection are often poor, which easily leads to aggregation, blockage of needle holes, and even formation of nodules during injection. Contents of the invention [0004] In order to solve the problem of poor fluidity of the existing gel for injection in the above-mentione...

Claims

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Application Information

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IPC IPC(8): A61L27/48A61L27/50A61L27/52A61L27/54A61L27/58
CPCA61L27/48A61L27/50A61L27/52A61L27/54A61L27/58A61L2400/06C08L5/08C08L89/00C08L5/06C08L67/04
Inventor 夏佩佩晏伟魏征
Owner YIPURUN SHANGHAI BIOTECH CO LTD
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